Constraints on (Omega_m,Omega_Lambda) using distributions of inclination angles for high redshift filaments

In this paper we present a scale free method to determine the cosmological parameters (Omega_m, Omega_Lambda). The method is based on the requirement of isotropy of the distribution of orientations of cosmological filaments. The current structure formation paradigm predicts that the first structures to form are voids and filaments, causing a web-like structure of the matter distribution at high redshifts. Recent observational evidence suggests that the threads, or filaments, of the cosmic web most easily are mapped in Ly-alpha emission. We describe how such a 3D map can be used to constrain the cosmological parameters in a way which, contrary to most other cosmological tests, does not require the use of a standard rod or a standard candle. We perform detailed simulations in order to define the optimal survey parameters for the definition of an observing programme aimed to address this test, and to investigate how statistical and observational errors will influence the results. We conclude that observations should target filaments of comoving size 15-50 Mpc in the redshift range 2-4, and that each filament must be defined by at least four Ly-alpha emitters. Detection of 20 filaments will be sufficient to obtain a result, while 50 filaments will make it possible to place significant new constraints on the values of Omega_m and Omega_Lambda permitted by the current supernova observations. In a future paper we study how robust these conclusions are to systematic velocities in the survey box.Comment: 8 pages, 6 figures, accepted for publication in A&

A Lyman-alpha blob in the GOODS South field: evidence for cold accretion onto a dark matter halo

We report on the discovery of a z = 3.16 Lyman-alpha emitting blob in the GOODS South field. The blob has a total Ly-alpha luminosity of ~ 10^(43) erg s^(-1) and a diameter larger than 60 kpc. The available multi-wavelength data in the GOODS field consists of 13 bands from X-rays (Chandra) to infrared (Spitzer). Unlike other discovered Ly-alpha blobs, this blob shows no obvious continuum counter-part in any of the broad-bands. In particular, no optical counter-parts are found in the deep HST/ACS imaging available. For previously published blobs, AGN (Active Galactic Nuclei) or 'superwind' models have been found to provide the best match with the data. We here argue that the most probable origin of the extended Ly-alpha emission from the blob in the GOODS South field is cold accretion onto a dark matter halo.Comment: 4 pages, 2 tables, 2 figures, Accepted to A&A Letters, minor changes to tex

Proposals for a practical calibration method for mechanical torque measurement on the wind turbine drive train under test on a test bench

The mechanical torque input into the wind turbine drive train is a very useful measurement for tests performed on a test bench. To ensure the accuracy and the reliability, an accurate calibration of the torque measurement must be carried out and repeated within a certain period of time. However, owing to the high torque level and large structure size, such a calibration is both expensive and time consuming. To overcome this challenge, a new calibration method is proposed here. The method is based on the electrical power measurement, where a high level of accuracy is much easier to achieve. With the help of a special test process, a relationship between the torque-measuring signal and the electrical power can be established. The process comprises two tests with the drive train running in different operating modes. The calibration is possible by carrying out the same test process on several different torque levels. Detailed uncertainty analysis of the method is presented, whereby the uncertainty can be calculated by means of matrix operation and also numerically. As a demonstration, the implementation of the method on a test bench drive train that contains two 5-MW motors in tandem with the motors operating in a back-to-back configuration is also presented. Finally, some variations on the method and possible ways of achieving better accuracy are discussed. © 2020 The Authors. Wind Energy published by John Wiley & Sons Lt

Production, growth and properties of ultrafine atmospheric aerosol particles in an urban environment

Number concentrations of atmospheric aerosol particles were measured by a flow-switching type differential mobility particle sizer in an electrical mobility diameter range of 6–1000 nm in 30 channels near central Budapest with a time resolution of 10 min continuously from 3 November 2008 to 2 November 2009. Daily median number concentrations of particles varied from 3.8 × 10<sup>3</sup> to 29 ×10<sup>3</sup> cm<sup>−3</sup> with a yearly median of 11.8 × 10<sup>3</sup> cm<sup>−3</sup>. Contribution of ultrafine particles to the total particle number ranged from 58 to 92% with a mean ratio and standard deviation of (79 ± 6)%. Typical diurnal variation of the particle number concentration was related to the major emission patterns in cities, new particle formation, sinks of particles and meteorology. Shapes of the monthly mean number size distributions were similar to each other. Overall mean for the number median mobility diameter of the Aitken and accumulation modes were 26 and 93 nm, respectively, which are substantially smaller than for rural or background environments. The Aitken and accumulation modes contributed similarly to the total particle number concentrations at the actual measurement location. New particle formation and growth unambiguously occurred on 83 days, which represent 27% of all relevant days. Hence, new particle formation and growth are not rare phenomena in Budapest. Their frequency showed an apparent seasonal variation with a minimum of 7.3% in winter and a maximum of 44% in spring. New particle formation events were linked to increased gas-phase H<sub>2</sub>SO<sub>4</sub> concentrations. In the studied area, new particle formation is mainly affected by condensation sink and solar radiation. The formation process seems to be not sensitive to SO<sub>2</sub>, which was present in a yearly median concentration of 6.7 μg m<sup>−3</sup>. This suggests that the precursor gas was always available in excess. Formation rate of particles with a diameter of 6 nm varied between 1.65 and 12.5 cm<sup>−3</sup> s<sup>−1</sup> with a mean and standard deviation of (4.2 ± 2.5) cm<sup>−3</sup> s<sup>−1</sup>. Seasonal dependency for the formation rate could not be identified. Growth curves of nucleated particles were usually superimposed on the characteristic diurnal pattern of road traffic direct emissions. The growth rate of the nucleation mode with a median diameter of 6 nm varied from 2.0 to 13.3 nm h<sup>−1</sup> with a mean and standard deviation of (7.7 ± 2.4) nm h<sup>−1</sup>. There was an indicative tendency for larger growth rates in summer and for smaller values in winter. New particle formation events increased the total number concentration by a mean factor and standard deviation of 2.3 ± 1.1 relative to the concentration that occurred immediately before the event. Several indirect evidences suggest that the new particle formation events occurred at least over the whole city, and were of regional type. The results and conclusions presented are the first information of this kind for the region over one-year long time period

A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis

Granulysin is an antimicrobial peptide (AMP) expressed by human T-lymphocytes and natural killer cells. Despite a remarkably broad antimicrobial spectrum, its implementation into clinical practice has been hampered by its large size and off-target effects. To circumvent these limitations, we synthesized a 29 amino acid fragment within the putative cytolytic site of Granulysin (termed “Gran1”). We evaluated the antimicrobial activity of Gran1 against the major human pathogen Mycobacterium tuberculosis (Mtb) and a panel of clinically relevant non-tuberculous mycobacteria which are notoriously difficult to treat. Gran1 efficiently inhibited the mycobacterial proliferation in the low micro molar range. Super-resolution fluorescence microscopy and scanning electron microscopy indicated that Gran1 interacts with the surface of Mtb, causing lethal distortions of the cell wall. Importantly, Gran1 showed no off-target effects (cytokine release, chemotaxis, cell death) in primary human cells or zebrafish embryos (cytotoxicity, developmental toxicity, neurotoxicity, cardiotoxicity). Gran1 was selectively internalized by macrophages, the major host cell of Mtb, and restricted the proliferation of the pathogen. Our results demonstrate that the hypothesis-driven design of AMPs is a powerful approach for the identification of small bioactive compounds with specific antimicrobial activity. Gran1 is a promising component for the design of AMP-containing nanoparticles with selective activity and favorable pharmacokinetics to be pushed forward into experimental in vivo models of infectious diseases, most notably tuberculosis

Quantum description of light pulse scattering on a single atom in waveguides

We present a time dependent quantum calculation of the scattering of a few-photon pulse on a single atom. The photon wave packet is assumed to propagate in a transversely strongly confined geometry, which ensures strong atom-light coupling and allows a quasi 1D treatment. The amplitude and phase of the transmitted, reflected and transversely scattered part of the wave packet strongly depend on the pulse length (bandwidth) and energy. For a transverse mode size of the order of $\lambda^2$, we find nonlinear behavior for a few photons already, or even for a single photon. In a second step we study the collision of two such wave packets at the atomic site and find striking differences between Fock state and coherent state wave packets of the same photon number.Comment: to appear in Phys. Rev.

Generating and probing a two-photon Fock state with a single atom in a cavity

A two-photon Fock state is prepared in a cavity sustaining a "source mode " and a "target mode", with a single circular Rydberg atom. In a third-order Raman process, the atom emits a photon in the target while scattering one photon from the source into the target. The final two-photon state is probed by measuring by Ramsey interferometry the cavity light shifts induced by the target field on the same atom. Extensions to other multi-photon processes and to a new type of micromaser are briefly discussed

Universal Continuous Variable Quantum Computation in the Micromaser

We present universal continuous variable quantum computation (CVQC) in the micromaser. With a brief history as motivation we present the background theory and define universal CVQC. We then show how to generate a set of operations in the micromaser which can be used to achieve universal CVQC. It then follows that the micromaser is a potential architecture for CVQC but our proof is easily adaptable to other potential physical systems.Comment: 12 pages, 4 figures, accepted for a presentation at the 9th International Conference on Unconventional Computation (UC10) and LNCS proceedings