Variability survey in the CoRoT SRa01 field: Implications of eclipsing binary distribution on cluster formation in NGC 2264

Time-series photometry of the CoRoT field SRa01 was carried out with the Berlin Exoplanet Search Telescope II (BEST II) in 2008/2009. A total of 1,161 variable stars were detected, of which 241 were previously known and 920 are newly found. Several new, variable young stellar objects have been discovered. The study of the spatial distribution of eclipsing binaries revealed the higher relative frequency of Algols toward the center of the young open cluster NGC 2264. In general Algol frequency obeys an isotropic distribution of their angular momentum vectors, except inside the cluster, where a specific orientation of the inclinations is the case. We suggest that we see the orbital plane of the binaries almost edge-on.Comment: 18 pages, 8 figures, accepted for publication in Ap

The Berlin Exoplanet Search Telescope II. Catalog of Variable Stars. I. Characterization of Three Southern Target Fields

A photometric survey of three Southern target fields with BEST II yielded the detection of 2,406 previously unknown variable stars and an additional 617 stars with suspected variability. This study presents a catalog including their coordinates, magnitudes, light curves, ephemerides, amplitudes, and type of variability. In addition, the variability of 17 known objects is confirmed, thus validating the results. The catalog contains a number of known and new variables that are of interest for further astrophysical investigations, in order to, e.g., search for additional bodies in eclipsing binary systems, or to test stellar interior models. Altogether, 209,070 stars were monitored with BEST II during a total of 128 nights in 2009/2010. The overall variability fraction of 1.2-1.5% in these target fields is well comparable to similar ground-based photometric surveys. Within the main magnitude range of $R\in\left[11,17\right]$, we identify 0.67(3)% of all stars to be eclipsing binaries, which indicates a completeness of about one third for this particular type in comparison to space surveys.Comment: accepted to A

HLA class I upregulation and antiviral immune responses in Graves' disease

This is the final version. Available on open access from Oxford University Press via the DOI in this record. Data Availability: Restrictions apply to some or all the availability of data generated or analyzed during this study to preserve patient confidentiality. The corresponding author will on request detail the restrictions and any conditions under which access to some data may be provided.CONTEXT: The origin of Graves' disease (GD) remains elusive. However, evidence of an association between GD and viral infections is emerging. Human leukocyte antigen (HLA) class I presents viral antigens to circulating immune cells and plays a crucial role in the defense against viral infections. OBJECTIVE: To investigate HLA class I expression, enterovirus presence and the viral immune response proteins signal transducer and activation of transcription 1 (STAT1) and protein kinase R (PKR) in thyroid tissue from GD patients. DESIGN AND PATIENTS: We collected thyroid tissue from core needle biopsies or surgical specimens from 48 GD patients and 24 controls. Standard immunohistochemistry was used to detect HLA class I and enteroviral capsid protein 1 (VP1) on formalin-fixed and paraffin-embedded tissue. STAT1 and PKR were examined by combined immunofluorescence staining. MAIN OUTCOME MEASURES: HLA class I expression score. RESULTS: The HLA class I expression score, which takes both proportion and intensity of immunostaining into account, was significantly higher in GDs (3.1±3.3) than in controls (0.5±0.9) (p<0.001). Significantly more VP1 positive thyroid cells were found GD samples (50.1± 30.5%) than in controls (14.9±10.5%) (p<0.001). STAT1 and HLA class I was found within the same thyroid cells and PKR and VP1 were also colocalized within thyroid cells. CONCLUSION: HLA class I is upregulated in GD and enterovirus protein is prevalent in thyroid tissue. The colocalization of HLA class I with STAT1 and VP1 with PKR indicates an antiviral tissue response. These findings support the concept of a link between viral infections and GD.European Union FP7(FP7/2007-2013)South-Eastern Norway Regional Health Authority (Helse Sør-Øst)University of OsloDiabetes Research Foundatio

BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation

Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as a modifier gene that exacerbates the phenotypic severity of Sox10 haplo-insufficient mice. Conditional deletion of Smarca4 in SOX10 expressing cells resulted in reduced numbers of cranial and ventral trunk melanoblasts. To define the requirement for the Smarca4 -encoded BRG1 subunit of the SWI/SNF chromatin remodeling complex, we employed in vitro models of melanocyte differentiation in which induction of melanocyte-specific gene expression is closely linked to chromatin alterations. We found that BRG1 was required for expression of Dct, Tyrp1 and Tyr, genes that are regulated by SOX10 and MITF and for chromatin remodeling at distal and proximal regulatory sites. SOX10 was found to physically interact with BRG1 in differentiating melanocytes and binding of SOX10 to the Tyrp1 distal enhancer temporally coincided with recruitment of BRG1. Our data show that SOX10 cooperates with MITF to facilitate BRG1 binding to distal enhancers of melanocyte-specific genes. Thus, BRG1 is a SOX10 co-activator, required to establish the melanocyte lineage and promote expression of genes important for melanocyte function

Heterogeneous Distribution of Chromium on Mercury

Measurements made with geochemical instruments on the MESSENGER spacecraft revealed that Mercury's crust is surprisingly rich in volatile elements, including S, Na, K, Cl, and C, and that it is enriched in Mg and depleted in Al, Ca, and Fe, relative to other terrestrial planets. Geochemical maps also indicated the presence of a number of distinct geochemical terranes. The MESSENGER X-ray Spectrometer (XRS) detected X-ray fluorescence, induced by incident solar X-rays, from the top approx. 10s of micrometers of Mercury's surface. Like Fe, Cr was only detectable by XRS during large solar flares. However, accurate Cr measurements are more susceptible to systematic errors than other elements measured by the XRS. Therefore, to date, Cr data have been published for only 11 XRS measurements, but we have recently derived a map of Cr/Si across Mercury's surface. This map is based on data acquired through the complete MESSENGER mission and reveals clear spatial heterogeneity in Cr

18 new variables in the Puppis field

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A Mercury Lander Mission Concept Study for the Next Decadal Survey

Mariner 10 provided our first closeup reconnaissance of Mercury during its three flybys in 1974 and 1975. MESSENGERs 20112015 orbital investigation enabled numerous discoveries, several of which led to substantial or complete changes in our fundamental understanding of the planet. Among these were the unanticipated, widespread presence of volatile elements (e.g., Na, K, S); a surface with extremely low Fe abundance whose darkening agent is likely C; a previously unknown landformhollows that may form by volatile sublimation from within rocks exposed to the harsh conditions on the surface; a history of expansive effusive and explosive volcanism; substantial radial contraction of the planet from interior cooling; offset of the dipole moment of the internal magnetic field northward from the geographic equator by ~20% of the planets radius; crustal magnetization, attributed at least in part to an ancient field; unexpected seasonal variability and relationships among exospheric species and processes; and the presence in permanently shadowed polar terrain of water ice and other volatile materials, likely to include complex organic compounds. Mercurys highly chemically reduced and unexpectedly volatile-rich composition is unique among the terrestrial planets and was not predicted by earlier hypotheses for the planets origin. As an end-member of terrestrial planet formation, Mercury holds unique clues about the original distribution of elements in the earliest stages of the Solar System and how planets (and exoplanets) form and evolve in close proximity to their host stars. The BepiColombo mission promises to expand our knowledge of this planet and to shed light on some of the mysteries revealed by the MESSENGER mission. However, several fundamental science questions raised by MESSENGERs pioneering exploration of Mercury can only be answered with in situ measurements from the planets surface

Improved Variable Star Search in Large Photometric Data Sets -- New Variables in CoRoT Field LRa02 Detected by BEST II

The CoRoT field LRa02 has been observed with the Berlin Exoplanet Search Telescope II (BEST II) during the southern summer 2007/2008. A first analysis of stellar variability led to the publication of 345 newly discovered variable stars. Now, a deeper analysis of this data set was used to optimize the variability search procedure. Several methods and parameters have been tested in order to improve the selection process compared to the widely used J index for variability ranking. This paper describes an empirical approach to treat systematic trends in photometric data based upon the analysis of variance statistics that can significantly decrease the rate of false detections. Finally, the process of reanalysis and method improvement has virtually doubled the number of variable stars compared to the first analysis by Kabath et al. A supplementary catalog of 272 previously unknown periodic variables plus 52 stars with suspected variability is presented. Improved ephemerides are given for 19 known variables in the field. In addition, the BEST II results are compared with CoRoT data and its automatic variability classification.Comment: 16 pages, 15 figures; figure set, machine-readable and VO tables available in the electronic edition of the Astronomical Journa

Vertical distribution of zooplankton in a shallow peatland pond: the limiting role of dissolved oxygen

We investigated the diel vertical distribution patterns of microcrustacean zooplankton (Cladocera, Copepoda) in a shallow pond (max. depth: 70 cm) of the Öreg-turján peatland (Ócsa, Central Hungary) during three 24-h periods in July (19–20th), August (17–18th) and September (11–12th) 2011. Environmental variables showed remarkable vertical stratification. Oxygen concentration was close to zero in the entire water column from night until sunrise, while the lower strata (from 20 cm below the surface) were close to anoxic during all three diel cycles. It proved to be the main determinant of the vertical distribution of microcrustaceans. Accordingly, the highest proportion of individuals was present in the surface layer. Chlorophyll-a concentration and phytoplankton biomass were inversely distributed compared to zooplankton. Microcrustaceans (mainly Daphnia curvirostris) migrated to the middle layer only in August, which could be explained by a trade-off between food resources, dissolved oxygen (DO) and competition with littoral zooplankters. The diurnal density patterns of microcrustaceans suggested horizontal migration into the aquatic macrophytes during night, which could be a strategy to avoid Chaoborus predation. Our results show that strong vertical gradients of abiotic and biotic factors occur even in such shallow waterbodies. Among them, DO can maintain constant vertical aggregation of zooplankters by limiting their occurrence to the surface layers