196 research outputs found
Report drawn up on behalf of the Committee on Social Affairs and Employment on the proposal from the Commission of the European Communities to the Council (COM (84) 57 final - Doc. 1-147/84) for a directive on the principle of equal treatment for men and women in self-employed occupations, including agriculture, and on protection during pregnancy and maternity. Working Documents 1984-85, Document 1-214/84, 7 May 1984
Interim Report drawn up on behalf of the Committee on Social Affairs and Employment on the publication of the Commission of the European Communities entitled "Social Security Problems" (COM(82) 716 final). Working Documents 1984-1985, Document 1-45/84, 2 April 1984
Report drawn up on behalf of the Committee on the Environment, Public Health and Consumer Protection on the proposal form the Commission of the European Communities to the Council (Doc. 1-333/80) for a decision establishing a Community information system for preventing and combating hydrocarbon pollution of the sea. Working Documents 1980-1981, Document 1-709/80, 7 January 1981
Design and manufacturing process for the KIT 2-MW 170-GHz coaxial-cavity longer-pulse gyrotron
Automated Generation of High-Order Modes for Tests of Quasi-Optical Systems of Gyrotrons for W7-X Stellarator
A test system for the verification of the quasi-optical converter system is vital in the gyrotron development. For this reason, an automated measurement setup has been developed and is benchmarked with the TE mode operating in the cavities of the gyrotrons of W7-X with a high purity of about 95 % and a counter-rotating amount of about 0.3 %. The time duration for the mode generator adjustment has been reduced to two days for this mode. After a successful mode excitation, the quasi-optical mode converter, consisting of a launcher and three mirrors, is measured having a vectorial Gaussian mode content of 97 %
Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex
Disrupted in Schizophrenia 1 (DISC1) is a prominent gene in mental illness research, encoding a scaffold protein known to be of importance in the developing cerebral cortex. Reelin is a critical extracellular protein for development and lamination of the prenatal cortex and which has also been independently implicated in mental illness. Regulation of reelin activity occurs through processing by the metalloproteinases ADAMTS-4 and ADAMTS-5. Through cross-breeding of heterozygous transgenic DISC1 mice with heterozygous reeler mice, which have reduced reelin, pups heterozygous for both phenotypeswere generated. Fromthese,we determine that transgenic DISC1 leads to a reduction in the processing of reelin, with implications for its downstream signalling element Dab1. An effect of DISC1 on reelin processing was confirmed in vitro, and revealed that intracellular DISC1 affects ADAMTS-4 protein, which in turn is exported and affects processing of extracellular reelin. In transgenic rat cortical cultures, an effect of DISC1 on reelin processing could also be seen specifically in early, immature neurons, but was lost in calretinin and reelin-positive mature neurons, suggesting cell-type specificity. DISC1 therefore acts upstream of reelin in the perinatal cerebral cortex in a cell type/time specific manner, leading to regulation of its activity through altered proteolytic cleavage. Thus a functional link is demonstrated between two proteins, each of independent importance for both cortical development and associated cognitive functions leading to behavioural maladaptation and mental illness
Design and manufacturing process for the KIT 2-MW 170-GHz coaxial-cavity longer-pulse gyrotron
ECCD-induced sawtooth crashes at W7-X
The optimised superconducting stellarator W7-X generates its rotational transform by means of
external coils, therefore no toroidal current is necessary for plasma confinement. Electron
cyclotron current drive experiments were conducted for strikeline control and safe divertor
operation. During current drive experiments periodic and repetitive crashes of the central
electron temperature, similar to sawtooth crashes in tokamaks, were detected. Measurements
from soft x-ray tomography and electron cyclotron emission show that the crashes are preceded
by weak oscillating precursors and a displacement of the plasma core, consistent with a
(m, n)=(1, 1) mode. The displacement occurs within 100μs, followed by expulsion and
redistribution of the core into the external part of the plasma. Two types of crashes, with
different frequencies and amplitudes are detected in the experimental program. For these
non-stationary parameters a strong dependence on the toroidal current is found. A 1-D heuristic
model for current diffusion is proposed as a first step to explain the characteristic crash time.
Initial results show that the modelled current diffusion timescale is consistent with the initial
crash frequency and that the toroidal current rise shifts the position where the instability is
triggered, resulting in larger crash amplitudes
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