545 research outputs found
Revised Generalized System of Preferences: Instant Replay or a Real Change
This article will discuss in detail the GSP in the United States. Ini- tially, it will examine the salient features of the original GSP program and subsequently the legislative hearings culminating in the extension of the GSP program. Finally, the article will explore the renewed version of the GSP and discuss its application
Revised Generalized System of Preferences: Instant Replay or a Real Change
This article will discuss in detail the GSP in the United States. Ini- tially, it will examine the salient features of the original GSP program and subsequently the legislative hearings culminating in the extension of the GSP program. Finally, the article will explore the renewed version of the GSP and discuss its application
Three-dimensional model study of the Arctic ozone loss in 2002/2003 and comparison with 1999/2000 and 2003/2004
We have used the SLIMCAT 3-D off-line chemical transport model (CTM) to quantify the Arctic chemical ozone loss in the year 2002/2003 and compare it with similar calculations for the winters 1999/2000 and 2003/2004. Recent changes to the CTM have improved the model's ability to reproduce polar chemical and dynamical processes. The updated CTM uses σ-θ as a vertical coordinate which allows it to extend down to the surface. The CTM has a detailed stratospheric chemistry scheme and now includes a simple NAT-based denitrification scheme in the stratosphere.
In the model runs presented here the model was forced by ECMWF ERA40 and operational analyses. The model used 24 levels extending from the surface to ~55km and a horizontal resolution of either 7.5° x 7.5° or 2.8° x 2.8°. Two different radiation schemes, MIDRAD and the CCM scheme, were used to diagnose the vertical motion in the stratosphere. Based on tracer observations from balloons and aircraft, the more sophisticated CCM scheme gives a better representation of the vertical transport in this model which includes the troposphere. The higher resolution model generally produces larger chemical O3 depletion, which agrees better with observations.
The CTM results show that very early chemical ozone loss occurred in December 2002 due to extremely low temperatures and early chlorine activation in the lower stratosphere. Thus, chemical loss in this winter started earlier than in the other two winters studied here. In 2002/2003 the local polar ozone loss in the lower stratosphere was ~40% before the stratospheric final warming. Larger ozone loss occurred in the cold year 1999/2000 which had a persistently cold and stable vortex during most of the winter. For this winter the current model, at a resolution of 2.8° x 2.8°, can reproduce the observed loss of over 70% locally. In the warm and more disturbed winter 2003/2004 the chemical O3 loss was generally much smaller, except above 620K where large losses occurred due to a period of very low minimum temperatures at these altitudes
Denial at the top table: status attributions and implications for marketing
Senior marketing management is seldom represented on the Board of Directors nowadays, reflecting a deteriorating status of the marketing profession. We examine some of the key reasons for marketing’s demise, and discuss how the status of marketing may be restored by demonstrating the value of marketing to the business community. We attribute marketing’s demise to several related key factors: narrow typecasting, marginalisation and limited involvement in product development, questionable marketing curricula, insensitivity toward environmental change, questionable professional standards and roles, and marketing’s apparent lack of accountability to CEOs. Each of these leads to failure to communicate, create, or deliver value within marketing. We argue that a continued inability to deal with marketing’s crisis of representation will further erode the status of the discipline both academically and professionally
Accounting for heterogeneity in θ-σ relationship:application to wheat phenotyping using ΕMI
Geophysical methods, such as electromagnetic induction (EMI), can be effective for monitoring changes in soil moisture at the field scale, particularly in agricultural applications. The electrical conductivity (σ) inferred from EMI needs to be converted to soil moisture content (θ) using an appropriate relationship. Typically, a single global relationship is applied to an entire agricultural field, however, soil heterogeneity at the field scale may limit the effectiveness of such an approach. One application area that may suffer from such an effect is crop phenotyping. Selecting crop varieties based on their root traits is important for crop breeding and maximizing yield. Hence, high throughput tools for phenotyping the root system architecture and activity at the field-scale are needed. Water uptake is a major root activity and, under appropriate conditions, can be approximated by measuring changes in soil moisture from time-lapse geophysical surveys. We examine here the effect of heterogeneity in the θ-σ relationship using a crop phenotyping study for illustration. In this study, the θ-σ relationship was found to vary substantially across a field site. To account for this, we propose a range of local (plot specific) θ-σ models. We show that the large number of parameters required for these models can be estimated from baseline σ and θ measurements. Finally, we compare the use of global (field scale) and local (plot scale) models with respect to ranking varieties based on the estimated soil moisture content change
An integrated general practice and pharmacy-based intervention to promote the use of appropriate preventive medications among individuals at high cardiovascular disease risk: protocol for a cluster randomized controlled trial
Background: Cardiovascular diseases (CVD) are responsible for significant morbidity, premature mortality, and economic burden. Despite established evidence that supports the use of preventive medications among patients at high CVD risk, treatment gaps remain. Building on prior evidence and a theoretical framework, a complex intervention has been designed to address these gaps among high-risk, under-treated patients in the Australian primary care setting. This intervention comprises a general practice quality improvement tool incorporating clinical decision support and audit/feedback capabilities; availability of a range of CVD polypills (fixed-dose combinations of two blood pressure lowering agents, a statin ± aspirin) for prescription when appropriate; and access to a pharmacy-based program to support long-term medication adherence and lifestyle modification.
Methods: Following a systematic development process, the intervention will be evaluated in a pragmatic cluster randomized controlled trial including 70 general practices for a median period of 18 months. The 35 general practices in the intervention group will work with a nominated partner pharmacy, whereas those in the control group will provide usual care without access to the intervention tools. The primary outcome is the proportion of patients at high CVD risk who were inadequately treated at baseline who achieve target blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) levels at the study end. The outcomes will be analyzed using data from electronic medical records, utilizing a validated extraction tool. Detailed process and economic evaluations will also be performed.
Discussion: The study intends to establish evidence about an intervention that combines technological innovation with team collaboration between patients, pharmacists, and general practitioners (GPs) for CVD prevention.
Trial registration: Australian New Zealand Clinical Trials Registry ACTRN1261600023342
Chemical and Photometric Evolution of Extended Ultraviolet Disks: Optical Spectroscopy of M83 (NGC5236) and NGC4625
We present the results from the analysis of optical spectra of 31
Halpha-selected regions in the extended UV (XUV) disks of M83 (NGC5236) and
NGC4625 recently discovered by GALEX. The spectra were obtained using IMACS at
Las Campanas Observatory 6.5m Magellan I telescope and COSMIC at the Palomar
200-inch telescope, respectively for M83 and NGC4625. The line ratios measured
indicate nebular oxygen abundances (derived from the R23 parameter) of the
order of Zsun/5-Zsun/10. For most emission-line regions analyzed the line
fluxes and ratios measured are best reproduced by models of photoionization by
single stars with masses in the range 20-40 Msun and oxygen abundances
comparable to those derived from the R23 parameter. We find indications for a
relatively high N/O abundance ratio in the XUV disk of M83. Although the
metallicities derived imply that these are not the first stars formed in the
XUV disks, such a level of enrichment could be reached in young spiral disks
only 1 Gyr after these first stars would have formed. The amount of gas in the
XUV disks allow maintaining the current level of star formation for at least a
few Gyr.Comment: 52 pages, 8 tables, 7 figures, accepted for publication in Ap
Seasonal Variations in Atmospheric Composition as Measured in Gale Crater, Mars
All MSL data used in this manuscript (REMS and SAM) are freely available on NASA's Planetary Data System (PDS) Geosciences Node, from within 6 months after receipt on Earth (http://pds‐geosciences.wustl.edu/missions/msl/). The mixing ratios developed and presented in this paper are available at a publicly available archive (dataverse.org: doi.org/10.7910/DVN/CVUOWW) as cited within the manuscript. The successful operation of the Curiosity rover and the SAM instrument on Mars is due to the hard work and dedication of hundreds of scientists, engineers, and managers over more than a decade. Essential contributions to the successful operation of SAM on Mars and the acquisition of SAM data were provided by the SAM development, operations, and test bed teams. The authors gratefully thank the SAM and MSL teams that have contributed in numerous ways to obtain the data that enabled this scientific work. We also thank NASA for the support of the development of SAM, SAM data analysis, and the continued support of the Mars Science Laboratory mission. The contribution of F. Lefèvre was supported by the Programme National de Planétologie (PNP). R. Navarro‐Gonzalez acknowledges support from the Universidad Nacional Autónoma de México (PAPIIT IN111619). LPI is operated by USRA under a cooperative agreement with the Science Mission Directorate of the National Aeronautics and Space Administration. We thank members of the SAM and larger MSL team for insightful discussions and support. In particular, we thank R. Becker and R. O. Pepin for careful review of data analysis and interpretation. We thank M. D. Smith for discussion of CRISM CO measurements. We thank A. Brunner, M. Johnson, and M. Lefavor for their development of customized data analysis tools used here and in other SAM publications.Peer reviewedPublisher PD
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD
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