Spaceborne Application Multiprocessor Operating System

Control Data Corporation, as part of a joint development program with the Boeing Electronics Company, built a nine node, three active module multiprocessor called SPA-l or Spaceborne Processor Array-I. (SPA was the processing system concept proposed as the heart of a multi-mission autonomous surveillance satellite in a paper presented at the 4th Annual AIAA/Utah State Small Satellite Conference in 1990). Since then, an operating system called the Operational Kernel, or OK, has been completed, tested, and functionally validated in a demonstration using the SPA-l. This demo featured fully autonomous on-board control of data movement, fault detection, fault isolation, hardware reconfiguration, application re-start, and load balancing/redistribution. The demo application consisted of ephemeris calculations being performed for two satellites, in each of three independent processors at different nodes on the SPA-I; this data (and SPA-l health status) was sent via a serial I/O (input/output) channel to a host machine for display. With the demo software running in the three active processing nodes, observers were invited to cause random nodal interconnect or processing hardware elements to fail by selection of switches on a fault injection panel. SPA-I, under the aegis of the OK, detected that a failure had occurred, isolated it, reconfigured around it, redistributed the processing load (to the two or one remaining active processors) and continued with the application processing, all without operator intervention of any sort. The OK is written in Ada. Support of the execution of Ada programs is provided for by the Ada Run Time System (RTS), provided by the Ada compilation system. The RTS provides very basic services such as tasking and memory management, and exception handling. The OK consists of Ada packages that are run on top of the RTS. This collection of packages include lower level services that involve message buffering, interrupt handling, and individual configuration commands. Operational high level services include: a block I/O facility that uses protocols to ensure the integrity of data transfers between modules at different nodes on the SPA network; a configuration facility that provides a high level set of operations to configure the network; and a health check facility to support application controlled detection and isolation of failed SPA elements. The SPA hardware, with processing elements operating essentially asynchronously at each node on the network, supports many concurrent activities. The OK handles this with Ada tasks. The number of tasks is application dependent. Approximately sixty tasks were employed in the SPA-l demo

Trust Development in the Supervisory Working Alliance

This qualitative study examined the development of trust in the supervisory relationship between doctoral-level student supervisors and masters-level students. Using phenomenological research methodology to analyze data obtained from 10 interviews with masters-level practicum students, six themes emerged: (1) Focus, (2) Investment, (3) Safety, (4) Honesty, (5) Expertise, and (6) Evaluation

Preferences in information processing and suicide : Results from a young adult health survey in the United Kingdom

Background: Suicide prevention literature currently suffers from inconsistent measurement and incomplete theoretical development. Aims: Using a recommended suicide measurement approach for epidemiological studies (i.e. the Suicidal Behaviors Questionnaire–Revised (SBQ-R)), the present investigation assessed United Kingdom young adult suicide prevalence rates. This study also investigated the utility of a Preferences in Information Processing (PIP) model of suicide in identifying those at increased odds for elevated suicide risk, as well as lifetime ideation and attempt. Method: A cross-sectional mental health and well-being survey study (n = 414) was conducted. Results: The prevalence rates of elevated risk (49.8%), lifetime ideation only (55.3%) and lifetime attempt (13.5%) were high. Bivariate associations demonstrated that elevated depression, anxiety and Need for Affect (NFA) Avoidance were associated with worsened suicide outcomes, whereas elevated Need for Cognition (NFC) was associated with decreased suicide risk. Logistic regression results identified depression and NFA Avoidance as the strongest predictors of elevated suicide risk. Multinomial logistic regression results established several PIP-based moderation effects for depression and anxiety in which NFA Approach and NFC differentially influenced odds of suicide attempt group membership. Conclusion: The SBQ-R is an appropriate tool for UK young adult suicide research. NFA and NFC demonstrated potential for inclusion in young adult suicide prevention programming. Further research is needed to fully evaluate the PIP model of suicide and effectiveness of proposed theory-based approaches to suicide prevention

GeneWeld: a method for efficient targeted integration directed by short homology

Choices for genome engineering and integration involve high efficiency with little or no target specificity or high specificity with low activity. Here, we describe a targeted integration strategy, called GeneWeld, and a vector series for gene tagging, pGTag (plasmids for Gene Tagging), which promote highly efficient and precise targeted integration in zebrafish embryos, pig fibroblasts, and human cells utilizing the CRISPR/Cas9 system. Our work demonstrates that in vivo targeting of a genomic locus of interest with CRISPR/Cas9 and a donor vector containing as little as 24 to 48 base pairs of homology directs precise and efficient knock-in when the homology arms are exposed with a double strand break in vivo. Given our results targeting multiple loci in different species, we expect the accompanying protocols, vectors, and web interface for homology arm design to help streamline gene targeting and applications in CRISPR compatible systems

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines - in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Erratum: Corrigendum: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

International Chicken Genome Sequencing Consortium. The Original Article was published on 09 December 2004. Nature432, 695–716 (2004). In Table 5 of this Article, the last four values listed in the ‘Copy number’ column were incorrect. These should be: LTR elements, 30,000; DNA transposons, 20,000; simple repeats, 140,000; and satellites, 4,000. These errors do not affect any of the conclusions in our paper. Additional information. The online version of the original article can be found at 10.1038/nature0315

Investigating the Impact of Supervisee Attachment System Activation on the Supervisory Relationship

Using a quasi-experimental design, the authors explored how supervisee attachment to supervisor predicted the supervisory relationship after recalling critical feedback from a supervisor. To examine effects of supervisee attachment system activation, participants were randomly assigned either to recall critical feedback from a supervisor (experimental condition) or to list objects in the room (control condition). Anxious and avoidant attachment to supervisor significantly predicted the supervisory relationship, but there were no significant differences among participants in either condition in predicting the supervisory relationship. Results are discussed in light of attachment theory, and implications for further investigating attachment dynamics in supervision are presented

David Margrett : a black missionary in the revolutionary Atlantic

David Margrett was a black missionary sent by the Countess of Huntingdon to preach to slaves in South Carolina and Georgia in 1774. Margrett did not confine his preaching in America to spiritual matters, instead speaking out against the system of slavery itself, and offering himself as a “second Moses.” Margrett's message was not well received by authorities in South Carolina, indeed he was fortunate to escape with his life. This article argues that Margrett was a product both of his evangelical training, where speaking out on important matters was encouraged, and also of his British environment, where anti-slavery voices were becoming increasingly prominent. The story of David Margrett demonstrates how black Britons received and interpreted the message of Christianity, and in particular how they used their faith as a means to attack slavery