Mirroring to Build Trust in Digital Assistants

We describe experiments towards building a conversational digital assistant that considers the preferred conversational style of the user. In particular, these experiments are designed to measure whether users prefer and trust an assistant whose conversational style matches their own. To this end we conducted a user study where subjects interacted with a digital assistant that responded in a way that either matched their conversational style, or did not. Using self-reported personality attributes and subjects' feedback on the interactions, we built models that can reliably predict a user's preferred conversational style.Comment: Preprin

How to use coping strategies and become more resilient

It is well recognised that the transition period from medical student to qualified doctor is a particularly demanding time. However, the life course of a doctor presents its own challenges of equal or greater significance and the job of a doctor is becoming increasingly difficult (Figley, Huggard and Rees 2013). Evidence for this relates to organisational, system, societal and clinical factors. Specifically: pressure of patient through-put; patient expectations; lack of organisational and social support; increasing isolation - no time to develop teams and communities of practice; and increasingly complex cases and patient co-morbidities. As doctors progress in their career they become increasingly responsible for the coordination of care in response to traumatic events and patient outcomes, while also managing outside pressures. Such factors can lead to an increase in errors (Jackson and Moreton 2013). Errors may be linked to patient diagnosis and treatment, performance of skills and errors in equipment use. Furthermore, the incidence of errors increases along with the amount of sick leave, with the performance of a growing number of doctors attracting scrutiny from the General Medical Council (GMC 2014). The topic of stress management and resilience has therefore attracted a great deal of attention. This ‘How to’ is a guide to strategies that can be used to relieve immediate physiological stress responses and when practised assist in the development of your resilience

Variational Saccading: Efficient Inference for Large Resolution Images

Image classification with deep neural networks is typically restricted to images of small dimensionality such as 224 x 244 in Resnet models [24]. This limitation excludes the 4000 x 3000 dimensional images that are taken by modern smartphone cameras and smart devices. In this work, we aim to mitigate the prohibitive inferential and memory costs of operating in such large dimensional spaces. To sample from the high-resolution original input distribution, we propose using a smaller proxy distribution to learn the co-ordinates that correspond to regions of interest in the high-dimensional space. We introduce a new principled variational lower bound that captures the relationship of the proxy distribution's posterior and the original image's co-ordinate space in a way that maximizes the conditional classification likelihood. We empirically demonstrate on one synthetic benchmark and one real world large resolution DSLR camera image dataset that our method produces comparable results with ~10x faster inference and lower memory consumption than a model that utilizes the entire original input distribution. Finally, we experiment with a more complex setting using mini-maps from Starcraft II [56] to infer the number of characters in a complex 3d-rendered scene. Even in such complicated scenes our model provides strong localization: a feature missing from traditional classification models.Comment: Published BMVC 2019 & NIPS 2018 Bayesian Deep Learning Worksho

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway may be neuroprotective, the role of Ryk in neurodegenerative disease remains unknown. We found that Ryk is up-regulated in neurons expressing mutant huntingtin (HTT) in several models of Huntington's disease (HD). Further investigation in Caenorhabditis elegans and mouse striatal cell models of HD provided a model in which the early-stage increase of Ryk promotes neuronal dysfunction by repressing the neuroprotective activity of the longevity-promoting factor FOXO through a noncanonical mechanism that implicates the Ryk-ICD fragment and its binding to the FOXO co-factor β-catenin. The Ryk-ICD fragment suppressed neuroprotection by lin-18/Ryk loss-of-function in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished β-catenin protection of mutant htt striatal cells against cell death vulnerability. Additionally, Ryk-ICD was increased in the nucleus of mutant htt cells, and reducing γ-secretase PS1 levels compensated for the cytotoxicity of full-length Ryk in these cells. These findings reveal that the Ryk-ICD pathway may impair FOXO protective activity in mutant polyglutamine neurons, suggesting that neurons are unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in HD. © 2014 Tourette et al

Kilonova Luminosity Function Constraints Based on Zwicky Transient Facility Searches for 13 Neutron Star Merger Triggers during O3

We present a systematic search for optical counterparts to 13 gravitational wave (GW) triggers involving at least one neutron star during LIGO/Virgo's third observing run (O3). We searched binary neutron star (BNS) and neutron star black hole (NSBH) merger localizations with the Zwicky Transient Facility (ZTF) and undertook follow-up with the Global Relay of Observatories Watching Transients Happen (GROWTH) collaboration. The GW triggers had a median localization area of 4480 deg², a median distance of 267 Mpc, and false-alarm rates ranging from 1.5 to 10⁻²⁵ yr⁻¹. The ZTF coverage in the g and r bands had a median enclosed probability of 39%, median depth of 20.8 mag, and median time lag between merger and the start of observations of 1.5 hr. The O3 follow-up by the GROWTH team comprised 340 UltraViolet/Optical/InfraRed (UVOIR) photometric points, 64 OIR spectra, and three radio images using 17 different telescopes. We find no promising kilonovae (radioactivity-powered counterparts), and we show how to convert the upper limits to constrain the underlying kilonova luminosity function. Initially, we assume that all GW triggers are bona fide astrophysical events regardless of false-alarm rate and that kilonovae accompanying BNS and NSBH mergers are drawn from a common population; later, we relax these assumptions. Assuming that all kilonovae are at least as luminous as the discovery magnitude of GW170817 (−16.1 mag), we calculate that our joint probability of detecting zero kilonovae is only 4.2%. If we assume that all kilonovae are brighter than −16.6 mag (the extrapolated peak magnitude of GW170817) and fade at a rate of 1 mag day⁻¹ (similar to GW170817), the joint probability of zero detections is 7%. If we separate the NSBH and BNS populations based on the online classifications, the joint probability of zero detections, assuming all kilonovae are brighter than −16.6 mag, is 9.7% for NSBH and 7.9% for BNS mergers. Moreover, no more than 10⁻⁴, or φ > 30° to be consistent with our limits. We look forward to searches in the fourth GW observing run; even 17 neutron star mergers with only 50% coverage to a depth of −16 mag would constrain the maximum fraction of bright kilonovae to <25%

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion