379 research outputs found
Teachersâ Perceptions of Studentsâ Writing Skills: An Examination of the Agreement Between Teachersâ Judgments and Curriculum-Based Measurement in Written Expression
Nearly 75% of students in the United States of America are not meeting grade-level standards in the area of writing (NCES, 2012; Persky et al., 2003), despite this skill impacting studentsâ performances in other academic areas (Ray et al., 2016), and limiting studentsâ access to higher education (Addison & McGee, 2010), and opportunities for jobs in the adult workforce (National Commission on Writing, 2005). Because difficulties with early writing skills are associated with later writing skills deficits (Juel, 1988), it is crucial that educators accurately identify students in need of additional support in order to provide them with appropriate instruction. Two common methods for identifying students are through teacher referral and standardized assessments such as Curriculum-Based Measurement-Written Expression (CBM-WE). Although levels of agreement between teacher referral and CBM-WE were examined in the past, this study extended the literature by conducting kappa analyses to investigate levels of agreement in order to take chance into account. In addition, due to differences in studentsâ performances on national assessments based on gender (Reilly et al., 2019), as well as differences between national and state normative data, levels of agreement were investigated as a function of gender and normative type. Results of this study suggest that levels of agreement may vary based on the CBM-WE scoring metric used and the studentâs gender, but no evidence was found to suggest using national or local norms impacted agreement. Furthermore, this study revealed poor levels of agreement for female students with writing skills below the 10th percentile across, suggesting that schools may need to use converging data sources to accurately identify female students in need of support. Limitations, directions for future research, and further implications are also discussed
S14RS SGFB No. 1 (Grad Student Symposium)
A FINANCE BILL
To appropriate a maximum of One thousand six hundred and seventy dollars and zero cents ($1,670.00) of the Student Senate Contingency to help with costs associated with organizing the Graduate Student Symposium held on February 21-23, 2014 at Louisiana University Marine Consortium (LUMCON) , sponsored by the Louisiana State University Agricultural and Mechanical College (LSU) Coast and Environmental Graduate Organization (CEGO
Doctrine and decision: navigating Labourâs new constitutional position in the Lords
The 2015â17 Parliament was the first time in history that the Conservatives were in government with no easily assembled majority in the House of Lords. This has fundamentally altered the role that Labour is able to play in the Lords and, conversely, that peers are able to play in the Labour party. Yet the political significance of this situation has not yet been fully appreciated by a party which remains culturally antagonistic and constitutionally wary of the Lords. In this paper, we draw on interviews with Labour peers, particularly the late Baroness Hollis of Heigham, who have been able to use the essentially conservative powers of the Lords for social democratic ends. We suggest that the Labour party needs to incorporate the second chamber into both its practical and symbolic politics, and to find ways to use this new source of constitutional power without accommodating to it
Developing digital interventions: a methodological guide.
Digital interventions are becoming an increasingly popular method of delivering healthcare as they enable and promote patient self-management. This paper provides a methodological guide to the processes involved in developing effective digital interventions, detailing how to plan and develop such interventions to avoid common pitfalls. It demonstrates the need for mixed qualitative and quantitative methods in order to develop digital interventions which are effective, feasible, and acceptable to users and stakeholders
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage
The Schizosaccharomyces pombe SMC proteins Rad18 (Smc6) and Spr18 (Smc5) exist in a high-M(r) complex which also contains the non-SMC proteins Nse1, Nse2, Nse3, and Rad62. The Smc5-6 complex, which is essential for viability, is required for several aspects of DNA metabolism, including recombinational repair and maintenance of the DNA damage checkpoint. We have characterized Nse2 and show here that it is a SUMO ligase. Smc6 (Rad18) and Nse3, but not Smc5 (Spr18) or Nse1, are sumoylated in vitro in an Nse2-dependent manner, and Nse2 is itself autosumoylated, predominantly on the C-terminal part of the protein. Mutations of C195 and H197 in the Nse2 RING-finger-like motif abolish Nse2-dependent sumoylation. nse2.SA mutant cells, in which nse2.C195S-H197A is integrated as the sole copy of nse2, are viable, whereas the deletion of nse2 is lethal. Smc6 (Rad18) is sumoylated in vivo: the sumoylation level is increased upon exposure to DNA damage and is drastically reduced in the nse2.SA strain. Since nse2.SA cells are sensitive to DNA-damaging agents and to exposure to hydroxyurea, this implicates the Nse2-dependent sumoylation activity in DNA damage responses but not in the essential function of the Smc5-6 complex
Revisiting Clickers: In-Class Questions Followed by At-Home Reflections Are Associated with Higher Student Performance on Related Exam Questions
Clicker questions are a commonly used active learning technique that stimulates student interactions to help advance understanding of key concepts. Clicker questions are often administered with an initial vote, peer discussion, and a second vote, followed by broader classroom explanation. While clickers can promote learning, some studies have questioned whether students maintain this performance on later exams, highlighting the need to further understand how student answer patterns relate to their understanding of the material and to identify ways for clickers to benefit a broader range of students. Systematic requizzing of concepts during at-home assignments represents a promising mechanism to improve student learning. Thus, we paired clicker questions with at-home follow-up reflections to help students articulate and synthesize their understandings. This pairing of clickers with homework allowed us to decipher how student answer patterns related to their underlying conceptions and to determine if revisiting concepts provided additional benefits. We found that students answering both clicker votes correctly performed better on isomorphic exam questions and that students who corrected their answers after the first vote did not show better homework or exam performance than students who maintained an incorrect answer across both votes. Furthermore, completing the followup homework assignment modestly boosted exam question performance. Our data suggest that longer-term benefits of clickers and associated homework may stem from students having repeated opportunities to retrieve, refine, and reinforce emerging conceptions
Regulation of neutrophilic inflammation by hypoxic signalling pathways
Neutrophils are essential for effective innate immunity. Conversely,
inappropriate or excessive neutrophil activation can result in damaging
inflammation. This damage is implicated in the pathogenesis of a number of
respiratory diseases including acute respiratory distress syndrome (ARDS)
and chronic obstructive pulmonary disease (COPD) which are also both
frequently complicated by hypoxia. Cells sense and respond to hypoxia
through the activity of the transcription factor HIF (hypoxia inducible factor) and
its regulatory hydroxylases, the prolyl hydroxylase domain enzymes (PHDs) 1-
3. In the presence of oxygen, PHDs hydroxylate HIF, preventing the HIF
mediated transcriptional response. Close links exist between the pathways
which regulate hypoxic and inflammatory responses. Our group has previously
found that in mouse models of infection, acute hypoxia leads to increased
sickness and that this is driven by neutrophilic inflammation.
I have used a murine model of Lipopolysaccharide (LPS) -induced acute lung
injury, characterised by neutrophil influx, to investigate how exposure to
hypoxia alters lung inflammation. Using high-resolution mass spectrometry, I
have defined the proteome of the inflammatory lung neutrophil. I have shown
that hypoxia results in a distinct proteomic signature in inflammatory
neutrophils. Hypoxia drives lung neutrophilic inflammation through increased
neutrophil degranulation and upregulation of inflammatory receptors.
I have also identified key metabolic alterations in hypoxic neutrophils. The
hypoxic lung represents a low glucose, high protein environment and
neutrophils adapt to exploit this. I have shown that neutrophils can scavenge
proteins from their extracellular environment, catabolise these proteins in the
lysosome and utilise the breakdown products for metabolism. These
processes are upregulated in hypoxic lung neutrophils which show increased
lysosomal protein expression, increased protein uptake and increased
glutaminolysis. Utilising heavy labelled protein extracts, I have traced
breakdown products from scavenged proteins into central carbon metabolism,
demonstrating that extracellular protein can fuel neutrophilic inflammation.
Finally, I have investigated the role of the prolyl hydroxylase PHD1 in
regulating neutrophilic inflammation. Using a neutrophil specific PHD1
knockout mouse line, I have identified a specific role for PHD1 in regulating
neutrophil metabolism and survival. I have found that the micro-environment,
particularly oxygen availability, determines the impact of PHD1 loss with
consequences for inflammation resolution in vivo.
In summary, hypoxia is a key regulator of neutrophil function and is associated
with increased neutrophilic inflammation. Utilising a proteomic approach, I
have identified the mechanisms which drive the hyperinflammatory phenotype
including the ability of neutrophils to scavenge proteins from the environment
to fuel inflammation. I have also shown that PHD1, a key component of the
hypoxic signalling pathway, may regulate these functions. A more complete
understanding of these mechanisms will help to identify therapeutic targets for
treatment of neutrophilic inflammation in the lung
A Primer on Batson, including Discussion of Johnson v. California, Miller-El v. Dretke, Rice v. Collins, & Synder v. Louisiana.
Fundamental to the existence of the rights guaranteed to every citizen is the assurance that the right to equal protection under the law will be defended at all costs. Key to the United Statesâ system of adjudication is the right to a trial by jury, which is embodied in the Sixth and Seventh Amendments to the Constitution. These rights are also incorporated into all state constitutions through the Fourteenth Amendment. During jury selection, the judicial system permits the elimination of a certain number of jurors without cause. This form of elimination is known as a peremptory challenge. Over time, however, the use of these challenges has transformed into a tool for purposeful discrimination. Recognizing this assault on the principle of equality, the United States Supreme Court in Batson v. Kentucky sought to end the unbridled use of peremptory challenges as a tool for racial discrimination. Unfortunately, Batson did not become the hoped-for cure; though over the past five years, on multiple occasions, the Supreme Court has explained, clarified, and fortified its Batson decision, Some circuit courts have cobbled together a divergent patchwork of different rules concerning applicability and waiver not decided by the Supreme Court. The circuit courts have engaged in their pursuit to answer lingering questions left by Batson. Such questions include whether challenging parties should rebut proffered race-neutral reasons to preserve error. Should trial and reviewing courts engage in sua sponte considerations of Miller-El II factors? What standard of review should an appellate court apply in reviewing trial court Batson determinations? These questions show the lack of uniformity between the circuit courts in the application of Johnson, Miller-El II, Rice, and Snyder. Until uniformity can be achieved, it is vital that practitioners recognize their respective circuitâs Batson jurisprudence when seeking to preserve clientsâ rights under Batson
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