820 research outputs found

    Performance Rights for Software

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    As we use software in increasingly varied contexts, the concept of a software license has become progressively more complex. Software is embedded in devices that do not obviously resemble computers. Web services make software on one computer available to anyone with internet access. An individual may use several computers over the course of the day so the concept of a node locked or individual license is no longer clear. How should time based and single use and consumptive licenses be governed and interact? This paper examines how these and other issues in software licensing can be seen as instances of the general concept of performance rights, rather than simply reproduction rights. Licenses involving finely specified performance rights are common in the entertainment industry for music, film, stage and television. We describe how, as software and our use of it becomes more sophisticated, we see performance rights as becoming an apt basis for software licensing

    Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

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    Glycogen availability can influence glucose transporter 4 (GLUT4) expression in skeletal muscle through unknown mechanisms. The multisubstrate enzyme AMP-activated protein kinase (AMPK) has also been shown to play an important role in the regulation of GLUT4 expression in skeletal muscle. During contraction, AMPK [alpha]2 translocates to the nucleus and the activity of this AMPK isoform is enhanced when skeletal muscle glycogen is low. In this study, we investigated if decreased pre-exercise muscle glycogen levels and increased AMPK [alpha]2 activity reduced the association of AMPK with glycogen and increased AMPK [alpha]2 translocation to the nucleus and GLUT4 mRNA expression following exercise. Seven males performed 60 min of exercise at ~70% [VO.sub.2] peak on 2 occasions: either with normal (control) or low (LG) carbohydrate pre-exercise muscle glycogen content. Muscle samples were obtained by needle biopsy before and after exercise. Low muscle glycogen was associated with elevated AMPK [alpha]2 activity and acetyl-CoA carboxylase [beta] phosphorylation, increased translocation of AMPK [alpha]2 to the nucleus, and increased GLUT4 mRNA. Transfection of primary human myotubes with a constitutively active AMPK adenovirus also stimulated GLUT4 mRNA, providing direct evidence of a role of AMPK in regulating GLUT4 expression. We suggest that increased activation of AMPK [alpha]2 under conditions of low muscle glycogen enhances AMPK [alpha]2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle. <br /

    Management challenges of traumatic spondylolisthesis of the Axis with an unusual C2-C3 posterior subluxation in a paediatric patient: case report and literature review

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    Introduction: Paediatric cervical spine injuries are uncommon. Traumatic spondylolisthesis of the axis (TSA) is commonly encountered in the trauma setting. The management of TSA may be surgical or non-surgical. Decision making is quite challenging depending on patient presentation and nature of injury, and even more so in the paediatric age group.Objectives: To present a case report highlighting the challenges in the management of TSA.Methods: We present an 8 year old male, who sustained a bilateral C2 pars fracture with associated unusual C2-C3 posterior subluxation.Results: Neuroradiological studies identified the fracture/subluxation of C2-C3 and revealed an intact but posteriorly displaced C2-C3 disc causing cord compression. An Extension Halter traction was initially commenced. This seemed to have worsened the patient’s neck pains, and caused motor weakness and autonomic dysfunction. An anterior cervical discectomy and fusion was finally decided on and performed after evaluation and brainstorming by our spinal Unit. Intra-operative findings revealed separation of the C2-C3 disc from the C3 superior end plate which probably explains the unusual nature of the subluxation.Conclusion: The case shows that surgical intervention as a primary management for TSA even in the paediatric age group is safe and also avoids risks inherent in conservative management.Keywords: Management challenges, traumatic spondylolisthesis of the axis, C2-C3 subluxation, paediatric, anterior cervical discectomy and fusion (ACDF)

    Mapping and explaining the productivity of Pinus radiata in New Zealand

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    Mapping Pinus radiata productivity for New Zealand not only provides useful information for forest owners, industry stakeholders and policy managers, but also enables current and future plantations to be visualised, quantified, and planned. Using an extensive set of permanent sample plots, split into fitting (n = 1,146) and validation (n = 618) datasets, models of P. radiata 300 Index (an index of volume mean annual increment) and Site Index (an index of height growth) were developed using a regression kriging technique. Spatial predictions were accurate and accounted for 61% and 70% of the variance for 300 Index and Site Index, respectively. Productivity predicted from these surfaces for the entire plantation estate averaged 27.4 m³ ha⁻¹ yr⁻¹ for the 300 Index and 30.4 m for Site Index. Surfaces showed wide regional variation in this productivity, which was attributable mainly to variation in air temperature and root-zone water storage from site to site

    Analysis of a model for ethanol production through continuous fermentation: ethanol productivity

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    We investigate a model for the production of ethanol through continuous fermentation using Saccharomyces cerevisiae in a single reactor and cascades of up to five reactors. Using path-following methods we investigate how the ethanol productivity varies with the residence time in each reactor of the cascade. With a substrate feed concentration of 160 g/l we find the optimal productivity is 3.80 g/l/h, 5.08 g/l/h, and 5.18 g/l/h in a single reactor, a double reactor cascade and a triple reactor cascade respectively. For the case of a cascade containing reactors of equal size we investigate reactor configurations of up to five reactors and find that the maximum productivity is obtained in a cascade containing three reactors
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