Enhanced Peculiar Velocities in Brane-Induced Gravity

The mounting evidence for anomalously large peculiar velocities in our Universe presents a challenge for the LCDM paradigm. The recent estimates of the large scale bulk flow by Watkins et al. are inconsistent at the nearly 3 sigma level with LCDM predictions. Meanwhile, Lee and Komatsu have recently estimated that the occurrence of high-velocity merging systems such as the Bullet Cluster (1E0657-57) is unlikely at a 6.5-5.8 sigma level, with an estimated probability between 3.3x10^{-11} and 3.6x10^{-9} in LCDM cosmology. We show that these anomalies are alleviated in a broad class of infrared-modifed gravity theories, called brane-induced gravity, in which gravity becomes higher-dimensional at ultra large distances. These theories include additional scalar forces that enhance gravitational attraction and therefore speed up structure formation at late times and on sufficiently large scales. The peculiar velocities are enhanced by 24-34% compared to standard gravity, with the maximal enhancement nearly consistent at the 2 sigma level with bulk flow observations. The occurrence of the Bullet Cluster in these theories is 10^4 times more probable than in LCDM cosmology.Comment: 15 pages, 6 figures. v2: added reference

Power Spectrum Estimation from Peculiar Velocity Catalogues

The peculiar velocities of galaxies are an inherently valuable cosmological probe, providing an unbiased estimate of the distribution of matter on scales much larger than the depth of the survey. Much research interest has been motivated by the high dipole moment of our local peculiar velocity field, which suggests a large scale excess in the matter power spectrum, and can appear to be in some tension with the LCDM model. We use a composite catalogue of 4,537 peculiar velocity measurements with a characteristic depth of 33 h-1 Mpc to estimate the matter power spectrum. We compare the constraints with this method, directly studying the full peculiar velocity catalogue, to results from Macaulay et al. (2011), studying minimum variance moments of the velocity field, as calculated by Watkins, Feldman & Hudson (2009) and Feldman, Watkins & Hudson (2010). We find good agreement with the LCDM model on scales of k > 0.01 h Mpc-1. We find an excess of power on scales of k < 0.01 h Mpc-1, although with a 1 sigma uncertainty which includes the LCDM model. We find that the uncertainty in the excess at these scales is larger than an alternative result studying only moments of the velocity field, which is due to the minimum variance weights used to calculate the moments. At small scales, we are able to clearly discriminate between linear and nonlinear clustering in simulated peculiar velocity catalogues, and find some evidence (although less clear) for linear clustering in the real peculiar velocity data.Comment: 10 pages, 13 figures, updated to match version accepted by MNRA

Precision measurements of large scale structure with future type Ia supernova surveys

Type Ia supernovae are currently the best known standard candles at cosmological distances. In addition to providing a powerful probe of dark energy they are an ideal source of information about the peculiar velocity field of the local universe. Even with the very small number of supernovae presently available it has been possible to measure the dipole and quadrupole of the local velocity field out to z~0.025. With future continuous all-sky surveys like the LSST project the luminosity distances of tens of thousands of nearby supernovae will be measured accurately. This will allow for a determination of the local velocity structure of the universe as a function of redshift with unprecedented accuracy, provided the redshifts of the host galaxies are known. Using catalogues of mock surveys we estimate that future low redshift supernova surveys will be able to probe sigma-8 to a precision of roughly 5% at 95% C.L. This is comparable to the precision in future galaxy and weak lensing surveys and with a relatively modest observational effort it will provide a crucial cross-check on future measurements of the matter power spectrum.Comment: 18 pages, 9 figures, submitted to JCA

Consistency of LCDM with Geometric and Dynamical Probes

The LCDM cosmological model assumes the existence of a small cosmological constant in order to explain the observed accelerating cosmic expansion. Despite the dramatic improvement of the quality of cosmological data during the last decade it remains the simplest model that fits remarkably well (almost) all cosmological observations. In this talk I review the increasingly successful fits provided by LCDM on recent geometric probe data of the cosmic expansion. I also briefly discuss some emerging shortcomings of the model in attempting to fit specific classes of data (eg cosmic velocity dipole flows and cluster halo profiles). Finally, I summarize recent results on the theoretically predicted matter overdensity ($\delta_m=\frac{\delta \rho_m}{\rho_m}$) evolution (a dynamical probe of the cosmic expansion), emphasizing its scale and gauge dependence on large cosmological scales in the context of general relativity. A new scale dependent parametrization which describes accurately the growth rate of perturbations even on scales larger than 100h^{-1}Mpc is shown to be a straightforward generalization of the well known scale independent parametrization f(a)=\omms(a)^\gamma valid on smaller cosmological scales.Comment: 20 pages, 6 figures. Invited review at the 1st Mediterranean Conference on Classical and Quantum Gravity (MCCQG). To appear in the proceeding

Large-scale collective motion of RFGC galaxies

We processed the data about radial velocities and HI linewidths for 1678 flat edge-on spirals from the Revised Flat Galaxy Catalogue. We obtained the parameters of the multipole components of large-scale velocity field of collective non-Hubble galaxy motion as well as the parameters of the generalized Tully-Fisher relationship in the "HI line width - linear diameter" version. All the calculations were performed independently in the framework of three models, where the multipole decomposition of the galaxy velocity field was limited to a dipole, quadrupole and octopole terms respectively. We showed that both the quadrupole and the octopole components are statistically significant. On the basis of the compiled list of peculiar velocities of 1623 galaxies we obtained the estimations of cosmological parameters Omega_m and sigma_8. This estimation is obtained in both graphical form and as a constraint of the value S_8=sigma_8(Omega_m/0.3)^0.35 = 0.91 +/- 0.05.Comment: Accepted for publication in Astrophysics and Space Scienc

Spontaneous DNA damage to the nuclear genome promotes senescence, T redox imbalance and aging

Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1-/Δ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1-/Δ mice accumulated spontaneous, oxidative DNA damage more rapidly than wild-type (WT) mice. As a consequence, senescent cells accumulated more rapidly in Ercc1-/Δ mice compared to repair-competent animals. However, the levels of DNA damage and senescent cells in Ercc1-/Δ mice never exceeded that observed in old WT mice. Surprisingly, levels of reactive oxygen species (ROS) were increased in tissues of Ercc1-/Δ mice to an extent identical to naturally-aged WT mice. Increased enzymatic production of ROS and decreased antioxidants contributed to the elevation in oxidative stress in both Ercc1-/Δ and aged WT mice. Chronic treatment of Ercc1-/Δ mice with the mitochondrial-targeted radical scavenger XJB-5–131 attenuated oxidative DNA damage, senescence and age-related pathology. Our findings indicate that nuclear genotoxic stress arises, at least in part, due to mitochondrial-derived ROS, and this spontaneous DNA damage is sufficient to drive increased levels of ROS, cellular senescence, and the consequent age-related physiological decline

An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans

Human, animal, and in vitro research indicates a beneficial effect of appropriate amounts of omega-3 (n-3) polyunsaturated fatty acids (PUFA) on bone health. This is the first controlled feeding study in humans to evaluate the effect of dietary plant-derived n-3 PUFA on bone turnover, assessed by serum concentrations of N-telopeptides (NTx) and bone-specific alkaline phosphatase (BSAP). Subjects (n = 23) consumed each diet for 6 weeks in a randomized, 3-period crossover design: 1) Average American Diet (AAD; [34% total fat, 13% saturated fatty acids (SFA), 13% monounsaturated fatty acids (MUFA), 9% PUFA (7.7% LA, 0.8% ALA)]), 2) Linoleic Acid Diet (LA; [37% total fat, 9% SFA, 12% MUFA, 16% PUFA (12.6% LA, 3.6% ALA)]), and 3) α-Linolenic Acid Diet (ALA; [38% total fat, 8% SFA, 12% MUFA, 17% PUFA (10.5% LA, 6.5% ALA)]). Walnuts and flaxseed oil were the predominant sources of ALA. NTx levels were significantly lower following the ALA diet (13.20 ± 1.21 nM BCE), relative to the AAD (15.59 ± 1.21 nM BCE) (p < 0.05). Mean NTx level following the LA diet was 13.80 ± 1.21 nM BCE. There was no change in levels of BSAP across the three diets. Concentrations of NTx were positively correlated with the pro-inflammatory cytokine TNFα for all three diets. The results indicate that plant sources of dietary n-3 PUFA may have a protective effect on bone metabolism via a decrease in bone resorption in the presence of consistent levels of bone formation

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume

The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-β PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-β positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimer’s disease-related phenotypes, including measures of cognition or brain Amyloid-β burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes