Spatiotemporal evolution, mineralogical composition, and transport mechanisms of long-runout landslides in Valles Marineris, Mars

Long-runout landslides with transport distances of >50 km are ubiquitous in Valles Marineris (VM), yet the transport mechanisms remain poorly understood. Four decades of studies reveal significant variation in landslide morphology and emplacement age, but how these variations are related to landslide transport mechanisms is not clear. In this study, we address this question by conducting systematic geological mapping and compositional analysis of VM long-runout landslides using high-resolution Mars Reconnaissance Orbiter imagery and spectral data. Our work shows that: (1) a two-zone morphological division (i.e., an inner zone characterized by rotated blocks and an outer zone expressed by a thin sheet with a nearly flat surface) characterizes all major VM landslides; (2) landslide mobility is broadly dependent on landslide mass; and (3) the maximum width of the outer zone and its transport distance are inversely related to the basal friction that was estimated from the surface slope angle of the outer zone. Our comprehensive Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) compositional analysis indicates that hydrated silicates are common in landslide outer zones and nearby trough-floor deposits. Furthermore, outer zones containing hydrated minerals are sometimes associated with longer runout and increased lateral spreading compared to those without detectable hydrated minerals. Finally, with one exception we find that hydrated minerals are absent in the inner zones of the investigated VM landslides. These results as whole suggest that hydrated minerals may have contributed to the magnitude of lateral spreading and long-distance forward transport of major VM landslides

Peroxisomal acyl-CoA synthetases

AbstractPeroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group—either a fatty acid or the acyl side chain of a steroid derivative—be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed. This thioesterification, or “activation”, reaction, catalyzed by enzymes belonging to the acyl-CoA synthetase family, is thus central to cellular lipid metabolism. However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4. In this review, we briefly describe the primary peroxisomal lipid metabolic pathways in which fatty acyl-CoAs participate. Then, we examine the evidence for presence and functions of acyl-CoA synthetases in peroxisomes, much of which was obtained before the existence of multiple acyl-CoA synthetase isoenzymes was known. Finally, we discuss the role(s) of peroxisome-specific acyl-CoA synthetase isoforms in lipid metabolism. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease

Spatiotemporal evolution, mineralogical composition, and transport mechanisms of long-runout landslides in Valles Marineris, Mars

Long-runout landslides with transport distances of >50 km are ubiquitous in Valles Marineris (VM), yet the transport mechanisms remain poorly understood. Four decades of studies reveal significant variation in landslide morphology and emplacement age, but how these variations are related to landslide transport mechanisms is not clear. In this study, we address this question by conducting systematic geological mapping and compositional analysis of VM long-runout landslides using high-resolution Mars Reconnaissance Orbiter imagery and spectral data. Our work shows that: (1) a two-zone morphological division (i.e., an inner zone characterized by rotated blocks and an outer zone expressed by a thin sheet with a nearly flat surface) characterizes all major VM landslides; (2) landslide mobility is broadly dependent on landslide mass; and (3) the maximum width of the outer zone and its transport distance are inversely related to the basal friction that was estimated from the surface slope angle of the outer zone. Our comprehensive Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) compositional analysis indicates that hydrated silicates are common in landslide outer zones and nearby trough-floor deposits. Furthermore, outer zones containing hydrated minerals are sometimes associated with longer runout and increased lateral spreading compared to those without detectable hydrated minerals. Finally, with one exception we find that hydrated minerals are absent in the inner zones of the investigated VM landslides. These results as whole suggest that hydrated minerals may have contributed to the magnitude of lateral spreading and long-distance forward transport of major VM landslides

Measuring area-level disadvantage in Australia : Development of a locally sensitive indicator

Background In Australia, the Socio-Economic Indexes for Areas (SEIFA), which includes the Index of Relative Socioeconomic Disadvantage (IRSD), captures the socioeconomic characteristics of areas. Because SEIFA rankings are relative to the country or state, the decile categorisations may not reflect an area’s socioeconomic standing relative to areas nearby. Aims The aim of the research was to explore whether IRSD rankings could be re-ranked to become locally sensitive. Data and methods Using existing SEIFA data to redistribute the membership of current decile IRSD groups, we tested three methods to re-rank all SA1 areas relative to the nearest areas capped at: (1) the nearest 99 neighbours, (2) a population threshold of 50,000 (3) a distance threshold of 10 km. Results The reclassification of SEIFA IRSD deciles was largest (up to 8 decile points of change) when comparing the nearest neighbour and population threshold local methods to current state-based rankings. Moreover, compared to using current national and state SEIFA IRSD rankings, the use of local rankings resulted in more evenly distributed deciles between cities, regional, and remote areas. Conclusions Because SEIFA IRSD rankings are used to allocate resources and health services, we encourage the combined use of a state and local ranking to refine areas considered the most disadvantaged

AIDS virus–specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape

Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17+ simian immunodeficiency virus (SIV)mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8+ T lymphocyte (CD8-TL) responses against a cryptic epitope, RHLAFKCLW (cRW9). Importantly, cRW9-specific CD8-TL selected for viral variation in vivo and effectively suppressed SIV replication in vitro, suggesting that they might play a key role in the SIV-specific response. The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus–specific cellular immune response is likely far more complex than is generally assumed

WISE/NEOWISE observations of Active Bodies in the Main Belt

We report results based on mid-infrared photometry of 5 active main belt objects (AMBOs) detected by the Wide-field Infrared Survey Explorer (WISE) spacecraft. Four of these bodies, P/2010 R2 (La Sagra), 133P/Elst-Pizarro, (596) Scheila, and 176P/LINEAR, showed no signs of activity at the time of the observations, allowing the WISE detections to place firm constraints on their diameters and albedos. Geometric albedos were in the range of a few percent, and on the order of other measured comet nuclei. P/2010 A2 was observed on April 2-3, 2010, three months after its peak activity. Photometry of the coma at 12 and 22 {\mu}m combined with ground-based visible-wavelength measurements provides constraints on the dust particle mass distribution (PMD), dlogn/dlogm, yielding power-law slope values of {\alpha} = -0.5 +/- 0.1. This PMD is considerably more shallow than that found for other comets, in particular inbound particle fluence during the Stardust encounter of comet 81P/Wild 2. It is similar to the PMD seen for 9P/Tempel 1 in the immediate aftermath of the Deep Impact experiment. Upper limits for CO2 & CO production are also provided for each AMBO and compared with revised production numbers for WISE observations of 103P/Hartley 2.Comment: 32 Pages, including 5 Figure

A one stop shop for cost-effectiveness evidence? Recommendations for improving Disease Control Priorities

Setting out a health benefits package (HBP) of interventions to be prioritised for funding is an important step towards achieving universal health coverage in low and middle income countries. The 3rd version of the Disease Control Priori-ties (DCP3) database, and other similar databases, aim to establishing a single point of reference (“one stop shop”) for cost effectiveness evidence to inform HBP design and other policy making. We reflect upon our experiences in using DCP3 for HBP design and offer suggestions for improving the future reporting of cost-effectiveness evidence. We appraise DCP3 based on generalisability, level of detail, and accessibility. We find that DCP and similar initiatives should be commended for the systematic assessment of a vast array of cost-effectiveness studies—the magnitude of such an endeavour is impressive in its own right. However, there are flaws. In future, providing disaggregated esti-mates of costs and effects, quantifying uncertainty, and systematically assessing the context in which estimates apply would make this evidence more useful for decision maker

Centaurs and Scattered Disk Objects in the Thermal Infrared: Analysis of WISE/NEOWISE Observations

The Wide-field Infrared Survey Explorer (WISE) observed 52 Centaurs and scattered disk objects (SDOs) in the thermal infrared, including 15 new discoveries. We present analyses of these observations to estimate sizes and mean optical albedos. We find mean albedos of 0.08 ± 0.04 for the entire data set. Thermal fits yield average beaming parameters of 0.9 ± 0.2 that are similar for both SDO and Centaur sub-classes. Biased cumulative size distributions yield size-frequency distribution power law indices of ~–1.7 ± 0.3. The data also reveal a relation between albedo and color at the 3σ level. No significant relation between diameter and albedos is found

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

An effective AIDS vaccine will need to protect against globally diverse isolates of HIV. To address this issue in macaques, we administered a live-attenuated simian immunodeficiency virus (SIV) vaccine and challenged with a highly pathogenic heterologous isolate. Vaccinees reduced viral replication by ∼2 logs between weeks 2–32 (P ≤ 0.049) postchallenge. Remarkably, vaccinees expressing MHC-I (MHC class I) alleles previously associated with viral control completely suppressed acute phase replication of the challenge virus, implicating CD8+ T cells in this control. Furthermore, transient depletion of peripheral CD8+ lymphocytes in four vaccinees during the chronic phase resulted in an increase in virus replication. In two of these animals, the recrudescent virus population contained only the vaccine strain and not the challenge virus. Alarmingly, however, we found evidence of recombinant viruses emerging in some of the vaccinated animals. This finding argues strongly against an attenuated virus vaccine as a solution to the AIDS epidemic. On a more positive note, our results suggest that MHC-I–restricted CD8+ T cells contribute to the protection induced by the live-attenuated SIV vaccine and demonstrate that vaccine-induced CD8+ T cell responses can control replication of heterologous challenge viruses