A two-fluid model for tissue growth within\ud a dynamic flow environment

We study the growth of a tissue construct in a perfusion bioreactor, focussing on its response to the mechanical environment. The bioreactor system is modelled as a two-dimensional channel containing a tissue construct through which a flow of culture medium is driven. We employ a multiphase formulation of the type presented by G. Lemon, J. King, H. Byrne, O. Jensen and K. Shakesheff in their study (Multiphase modelling of tissue growth using the theory of mixtures. J. Math. Biol. 52(2), 2006, 571–594) restricted to two interacting fluid phases, representing a cell population (and attendant extracellular matrix) and a culture medium, and employ the simplifying limit of large interphase viscous drag after S. Franks in her study (Mathematical Modelling of Tumour Growth and Stability. Ph.D. Thesis, University of Nottingham, UK, 2002) and S. Franks and J. King in their study (Interactions between a uniformly proliferating tumour and its surrounding: Uniform material properties. Math. Med. Biol. 20, 2003, 47–89).\ud \ud The novel aspects of this study are: (i) the investigation of the effect of an imposed flow on the growth of the tissue construct, and (ii) the inclusion of a mechanotransduction mechanism regulating the response of the cells to the local mechanical environment. Specifically, we consider the response of the cells to their local density and the culture medium pressure. As such, this study forms the first step towards a general multiphase formulation that incorporates the effect of mechanotransduction on the growth and morphology of a tissue construct. The model is analysed using analytic and numerical techniques, the results of which illustrate the potential use of the model to predict the dominant regulatory stimuli in a cell population

Analysis of sounding rocket data regarding celestial X-ray sources Final report

Celestial observation, sounding rocket data, and emission spectrum used to identify Sco X-1 of Scorpio constellatio

A program of X-ray astronomy from sounding rocket Final report

X-ray astronomy from sounding rocket

New periodic orbits in the solar sail three-body problem

We identify displaced periodic orbits in the circular restricted three-body problem, wher the third (small) body is a solar sail. In particular, we consider solar sail orbits in the earth-sun system which are high above the exliptic plane. It is shown that periodic orbits about surfaces of artificial equilibria are naturally present at linear order. Using the method of Lindstedt-Poincare, we construct nth order approximations to periodic solutions of the nonlinear equations of motion. In the second part of the paper we generalize to the solar sail elliptical restricted three-body problem. A numerical continuation, with the eccentricity, e, as the varying parameter, is used to find periodic orbits above the ecliptic, starting from a known orbit at e=0 and continuing to the requied eccentricity of e=0.0167. The stability of these periodic orbits is investigated

Performance of private sector health care: implications for universal health coverage

Although the private sector is an important health-care provider in many low-income and middle-income countries, its role in progress towards universal health coverage varies. Studies of the performance of the private sector have focused on three main dimensions: quality, equity of access, and efficiency. The characteristics of patients, the structures of both the public and private sectors, and the regulation of the sector influence the types of health services delivered, and outcomes. Combined with characteristics of private providers—including their size, objectives, and technical competence—the interaction of these factors affects how the sector performs in different contexts. Changing the performance of the private sector will require interventions that target the sector as a whole, rather than individual providers alone. In particular, the performance of the private sector seems to be intrinsically linked to the structure and performance of the public sector, which suggests that deriving population benefit from the private health-care sector requires a regulatory response focused on the health-care sector as a whole

The Infrared Continuum Sizes of Be Star Disks

We present an analysis of the near-infrared continuum emission from the circumstellar gas disks of Be stars using a radiative transfer code for a parametrized version of the viscous decretion disk model. This isothermal gas model creates predicted images that we use to estimate the HWHM emission radius along the major axis of the projected disk and the spatially integrated flux excess at wavelengths of 1.7, 2.1, 4.8, 9, and 18 ?m. We discuss in detail the effect of the disk base density, inclination angle, stellar effective temperature, and other physical parameters on the derived disk sizes and color excesses. We calculate color excess estimates relative to the stellar V -band flux for a sample of 130 Be stars using photometry from 2MASS and the AKARI infrared camera all-sky survey. The color excess relations from our models make a good match of the observed color excesses of Be stars. We also present our results on the projected size of the disk as a function of wavelength for the classical Be star ? Tauri, and we show that the model predictions are consistent with interferometric observations in the H, K', and 12 \mu m bands

Detecting Extrasolar Planets with Integral Field Spectroscopy

Observations of extrasolar planets using Integral Field Spectroscopy (IFS), if coupled with an extreme Adaptive Optics system and analyzed with a Simultaneous Differential Imaging technique (SDI), are a powerful tool to detect and characterize extrasolar planets directly; they enhance the signal of the planet and, at the same time, reduces the impact of stellar light and consequently important noise sources like speckles. In order to verify the efficiency of such a technique, we developed a simulation code able to test the capabilities of this IFS-SDI technique for different kinds of planets and telescopes, modelling the atmospheric and instrumental noise sources. The first results obtained by the simulations show that many significant extrasolar planet detections are indeed possible using the present 8m-class telescopes within a few hours of exposure time. The procedure adopted to simulate IFS observations is presented here in detail, explaining in particular how we obtain estimates of the speckle noise, Adaptive Optics corrections, specific instrumental features, and how we test the efficiency of the SDI technique to increase the signal-to-noise ratio of the planet detection. The most important results achieved by simulations of various objects, from 1 M_J to brown dwarfs of 30 M_J, for observations with an 8 meter telescope, are then presented and discussed.Comment: 60 pages, 37 figures, accepted in PASP, 4 Tables adde

The interplay between tissue growth and scaffold degradation in engineered tissue constructs

In vitro tissue engineering is emerging as a potential tool to meet the high demand for replacement tissue, caused by the increased incidence of tissue degeneration and damage. A key challenge in this field is ensuring that the mechanical properties of the engineered tissue are appropriate for the in vivo environment. Achieving this goal will require detailed understanding of the interplay between cell proliferation, extracellular matrix (ECM) deposition and scaffold degradation.\ud \ud In this paper, we use a mathematical model (based upon a multiphase continuum framework) to investigate the interplay between tissue growth and scaffold degradation during tissue construct evolution in vitro. Our model accommodates a cell population and culture medium, modelled as viscous fluids, together with a porous scaffold and ECM deposited by the cells, represented as rigid porous materials. We focus on tissue growth within a perfusion bioreactor system, and investigate how the predicted tissue composition is altered under the influence of (i) differential interactions between cells and the supporting scaffold and their associated ECM, (ii) scaffold degradation, and (iii) mechanotransduction-regulated cell proliferation and ECM deposition.\ud \ud Numerical simulation of the model equations reveals that scaffold heterogeneity typical of that obtained from μCT scans of tissue engineering scaffolds can lead to significant variation in the flow-induced mechanical stimuli experienced by cells seeded in the scaffold. This leads to strong heterogeneity in the deposition of ECM. Furthermore, preferential adherence of cells to the ECM in favour of the artificial scaffold appears to have no significant influence on the eventual construct composition; adherence of cells to these supporting structures does, however, lead to cell and ECM distributions which mimic and exaggerate the heterogeneity of the underlying scaffold. Such phenomena have important ramifications for the mechanical integrity of engineered tissue constructs and their suitability for implantation in vivo

7-Li(p,n) Nuclear Data Library for Incident Proton Energies to 150 MeV

We describe evaluation methods that make use of experimental data, and nuclear model calculations, to develop an ENDF-formatted data library for the reaction p + Li7 for incident protons with energies up to 150 MeV. The important 7-Li(p,n_0) and 7-Li(p,n_1) reactions are evaluated from the experimental data, with their angular distributions represented using Lengendre polynomial expansions. The decay of the remaining reaction flux is estimated from GNASH nuclear model calculations. The evaluated ENDF-data are described in detail, and illustrated in numerous figures. We also illustrate the use of these data in a representative application by a radiation transport simulation with the code MCNPX.Comment: 11 pages, 8 figures, LaTeX, submitted to Proc. 2000 ANS/ENS International Meeting, Nuclear Applications of Accelerator Technology (AccApp00), November 12-16, Washington, DC, US

Mid-infrared interferometry of massive young stellar objects. I. VLTI and Subaru observations of the enigmatic object M8E-IR

[abridged] Our knowledge of the inner structure of embedded massive young stellar objects is still quite limited. We attempt here to overcome the spatial resolution limitations of conventional thermal infrared imaging. We employed mid-infrared interferometry using the MIDI instrument on the ESO/VLTI facility to investigate M8E-IR, a well-known massive young stellar object suspected of containing a circumstellar disk. Spectrally dispersed visibilities in the 8-13 micron range were obtained at seven interferometric baselines. We resolve the mid-infrared emission of M8E-IR and find typical sizes of the emission regions of the order of 30 milli-arcseconds (~45 AU). Radiative transfer simulations have been performed to interpret the data. The fitting of the spectral energy distribution, in combination with the measured visibilities, does not provide evidence for an extended circumstellar disk with sizes > 100 AU but requires the presence of an extended envelope. The data are not able to constrain the presence of a small-scale disk in addition to an envelope. In either case, the interferometry measurements indicate the existence of a strongly bloated, relatively cool central object, possibly tracing the recent accretion history of M8E-IR. In addition, we present 24.5 micron images that clearly distinguish between M8E-IR and the neighbouring ultracompact HII region and which show the cometary-shaped infrared morphology of the latter source. Our results show that IR interferometry, combined with radiative transfer modelling, can be a viable tool to reveal crucial structure information on embedded massive young stellar objects and to resolve ambiguities arising from fitting the SED.Comment: 7 pages, 5 figures, accepted for publication in A&A, new version after language editing, one important reference added, conclusions unchange