A Multiple Case Study Identifying Factors Influencing Church Attendance and Engagement with Unchurched and Dechurched Families

Many medium-sized churches experienced significant growth followed by years of declining attendance (Haskell et al., 2016). Many of them are in locations that could allow for significant growth. It seems as if some once growing churches no longer recognize how to best reach their communities and how to minister to the needs of the families making up their surrounding communities. The purpose of this multiple case study, a comparative analysis, is to identify factors that positively and negatively influence church attendance and engagement among unchurched and de-churched persons and families. At this stage in the research, regular attendance and engagement will be defined as at least twice monthly attendance at a local SBC church. Twenty-one full-time ministers and 31 members in Floridian SBC churches were selected as a cross-sectional systematic sampling to be studied in this research study. Information concerning the churches’ surrounding populations were derived from the United States Census, the churches’ county and city research population statistics, Lifeway Research, Barna Group, and surveys that have been conducted by the Florida State Baptist Association. This multiple case study, a qualitative, comparative analysis was done by interviews in small groups of five subjects or less. One-on-one interviews were conducted to clarify the findings from the small group interviews. It also involved gathering information from the church’s record databases. The researcher also spent significant time observing and recording habits, practices, expectations, rules, and rites of the subject churches

Issues Associated with EFF & FDM Ceramic Filled Feedstock Formulation

Mechanical Engineerin

Fry Street Quartet

This program features music by composers who were enchanted by different idioms found in folk music. Michael Ellison and Antonín Dvořák were deliberate in their use of folk models. Melodies and textures that evoke Czech, American, and Turkish folk music play a central role in the respective musical identity of each composer.https://digitalcommons.usu.edu/music_programs/1204/thumbnail.jp

Fry Street Quartet

A performance by the Fry Street Quartet with special guests Kathryn Eberle and Jason Hardink.https://digitalcommons.usu.edu/music_programs/1226/thumbnail.jp

frystreet + friends

A performance of the Fry Street Quartet and others at the Performance Hall at Utah State University, performed on November 8, 2012.https://digitalcommons.usu.edu/music_programs/1174/thumbnail.jp

Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection

It has been shown that inter-individual variation in host response to porcine reproductive and respiratory syndrome (PRRS) has a heritable component, yet little is known about the underlying genetic architecture of gene expression in response to PRRS virus (PRRSV) infection. Here, we integrated genome-wide genotype, gene expression, viremia level, and weight gain data to identify genetic polymorphisms that are associated with variation in inter-individual gene expression and response to PRRSV infection in pigs. RNA-seq analysis of peripheral blood samples collected just prior to experimental challenge (day 0) and at 4, 7, 11 and 14 days post infection from 44 pigs revealed 6,430 differentially expressed genes at one or more time points post infection compared to the day 0 baseline. We mapped genetic polymorphisms that were associated with inter-individual differences in expression at each day and found evidence of cis-acting expression quantitative trait loci (cis-eQTL) for 869 expressed genes (qval \u3c 0.05). Associations between cis-eQTL markers and host response phenotypes using 383 pigs suggest that host genotype-dependent differences in expression of GBP5, GBP6, CCHCR1 and CMPK2 affect viremia levels or weight gain in response to PRRSV infection

Nanoporous sponges as carbon-based sorbents for atmospheric water generation

Water scarcity threatens more and more people in the world. Moisture adsorption from the atmosphere represents a promising avenue to provide fresh water. Nanoporous sponges (“NPSs” ), new carbon-based sorbents synthesized from the pyrolysis of resorcinol-formaldehyde resin, can achieve comparable performance to metal organic framework-based systems, but at a significantly lower cost. Oxygen and nitrogen functionalities can be added to the NPS surface, through oxidation and addition of phenanthroline to the initial reagent mixture, respectively. The resulting NPS sorbents have high specific surface areas of 347 to 527 m2·g–1 and an average capillary-condensation-compatible pore size of 1.5 nm. When oxidized, the NPS can capture up to 0.28 g of water per gram of adsorbent at a relative pressure of 0.90 (0.14 g·g–1 at P/Psat = 0.40) and maintain this adsorption capacity over multiple adsorption/desorption cycles. Scaled-up synthesis of the NPS was performed and tested in an experimental water capture setup, showing good agreement between small- and larger-scale adsorption properties. Water adsorption isotherms fitted with the theoretical model proposed by Do and Do demonstrate that hydroxyl functionalities are of key importance to NPS behavior

A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory events that lead to disease pathology remain poorly targeted with therapeutics. Here we implement an integrated network interrogation approach, in which proteome and transcriptome datasets from infection of both viruses in human lung epithelial cells are utilized to predict regulatory genes involved in the host response. We take advantage of a novel "crowd-based" approach to identify and combine ranking metrics that isolate genes/proteins likely related to the pathogenicity of SARS-CoV and influenza virus. Subsequently, a multivariate regression model is used to compare predicted lung epithelial regulatory influences with data derived from other respiratory virus infection models. We predicted a small set of regulatory factors with conserved behavior for consideration as important components of viral pathogenesis that might also serve as therapeutic targets for intervention. Our results demonstrate the utility of integrating diverse 'omic datasets to predict and prioritize regulatory features conserved across multiple pathogen infection models

Inside Post-Socialist Courts: The Determinants of Adjudicatory Outcomes in Slovenian Commercial Disputes

Despite the judiciary's central role in the capitalist market system, micro-level empirical analyses of courts in post-socialist countries are remarkably rare. This paper draws on a unique hand-collected dataset of commercial claims filed at Slovenian courts to examine the determinants of two salient adjudicatory outcomes: whether a case was resolved via trial or settlement and if the case was tried, whether the plaintiff was awarded the initial claim. Consistent with the divergent expectations theory of litigation, we find that trial-based resolution is more likely when the case is complex and less likely when parties use mediation. Addressing sample selection and endogeneity concerns, we show that defendant's legal representation, plaintiff's profitability, and, importantly, court identity are robust predictors of plaintiff victory at trial. Thus, more than two decades after the start of transition in Slovenia, the judicial system is still a source of legal inconsistency and uncertainty

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Background Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH. Methods In this multicentre, randomised, double-blind, placebo-controlled study, adult patients with definite NASH,non-alcoholic fatty liver disease (NAFLD) activity score of at least 4, and fibrosis stages F2–F3, or F1 with at least oneaccompanying comorbidity, were randomly assigned using an interactive web response system in a 1:1:1 ratio to receive oral placebo, obeticholic acid 10 mg, or obeticholic acid 25 mg daily. Patients were excluded if cirrhosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were present. The primary endpointsfor the month-18 interim analysis were fibrosis improvement (≥1 stage) with no worsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered successful if either primary endpoint was met. Primary analyses were done by intention to treat, in patients with fibrosis stage F2–F3 who received at least one dose of treatment and reached, or would have reached, the month 18 visit by the prespecified interim analysis cutoff date. The study also evaluated other histological and biochemical markers of NASH and fibrosis, and safety. This study is ongoing, and registered with ClinicalTrials.gov, NCT02548351, and EudraCT, 20150-025601-6. Findings Between Dec 9, 2015, and Oct 26, 2018, 1968 patients with stage F1–F3 fibrosis were enrolled and received at least one dose of study treatment; 931 patients with stage F2–F3 fibrosis were included in the primary analysis (311 in the placebo group, 312 in the obeticholic acid 10 mg group, and 308 in the obeticholic acid 25 mg group). The fibrosis improvement endpoint was achieved by 37 (12%) patients in the placebo group, 55 (18%) in the obeticholic acid 10 mg group (p=0·045), and 71 (23%) in the obeticholic acid 25 mg group (p=0·0002). The NASH resolution endpoint was not met (25 [8%] patients in the placebo group, 35 [11%] in the obeticholic acid 10 mg group [p=0·18], and 36 [12%] in the obeticholic acid 25 mg group [p=0·13]). In the safety population (1968 patients with fibrosis stages F1–F3), the most common adverse event was pruritus (123 [19%] in the placebo group, 183 [28%] in the obeticholic acid 10 mg group, and 336 [51%] in the obeticholic acid 25 mg group); incidence was generally mild to moderate in severity. The overall safety profile was similar to that in previous studies, and incidence of serious adverse events was similar across treatment groups (75 [11%] patients in the placebo group, 72 [11%] in the obeticholic acid 10 mg group, and 93 [14%] in the obeticholic acid 25 mg group). Interpretation Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH. The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes