Optical control of individual carbon nanotube light emitters by spectral double resonance in silicon microdisk resonators

Single-walled carbon nanotubes have advantages as a nanoscale light source compatible with silicon photonics because they show room-temperature luminescence at telecom-wavelengths and can be directly synthesized on silicon substrates. Here we demonstrate integration of individual light-emitting carbon nanotubes with silicon microdisk resonators. Photons emitted from nanotubes are efficiently coupled to whispering gallery modes, circulating within the disks and lighting up their perimeters. Furthermore, we control such emission by tuning the excitation wavelength in and out of resonance with higher order modes in the same disk. Our results open up the possibilities of using nanotube emitters embedded in photonic circuits that are individually addressable through spectral double resonance.Comment: 5 pages, 4 figure

Enhancement of carbon nanotube photoluminescence by photonic crystal nanocavities

Photonic crystal nanocavities are used to enhance photoluminescence from single-walled carbon nanotubes. Micelle-encapsulated nanotubes are deposited on nanocavities within Si photonic crystal slabs and confocal microscopy is used to characterize the devices. Photoluminescence spectra and images reveal nanotube emission coupled to nanocavity modes. The cavity modes can be tuned throughout the emission wavelengths of carbon nanotubes, demonstrating the ability to enhance photoluminescence from a variety of chiralities.Comment: 4 pages, 3 figure

Ferromagnetic to spin glass cross over in (La,Tb)_{2/3}Ca_{1/3}MnO_{3}

In the series La_{2/3-x}Tb_{x}Ca_{1/3}MnO_{3}, it is known that the compositions are ferromagnetic for smaller values of x and show spin glass characteristics at larger values of x. Our studies on the magnetic properties of various compositions in the La_{2/3-x}Tb_{x}Ca_{1/3}MnO_{3} series show that the cross over from ferromagnetic to spin glass region takes place above x ~ 1/8. Also, a low temperature anomaly at 30 K, observed in the ac susceptibility curves, disappears for compositions above this critical value of x. A mixed phase region coexists in the narrow compositional range 0.1 <= x <= 0.125, indicating that the ferromagnetic to spin glass cross over is not abrupt.Comment: 5 pages, 5 figure

Numerical Observation of the Rescattering Wave Packet in Laser-Atom Interactions

We present a full-quantum nonperturbative method to study the electron rescattering process in the intense laser-atom interactions. We separate the ionized wave function from the background by solving the time-integral equation. Imposing the incoming boundary condition on the wave function, we reproduce the motion of the rescattering wave packet predicted by the rescattering theory. Our calculated rescattering energies differ significantly from the semiclassical ones. The difference would be substantial for the evaluation of the rescattering induced dynamics such as the molecular dissociation

Optical control of individual carbon nanotube light emitters by spectral double resonance in silicon microdisk resonators

We demonstrate integration of individual light-emitting carbon nanotubes with silicon microdisk resonators. Photons emitted from nanotubes are efficiently coupled to whispering gallery modes, circulating within the disks and lighting up their perimeters. Furthermore, we control such emission by tuning the excitation wavelength in and out of resonance with higher order modes in the same disk. Our results open up the possibilities of using nanotube emitters embedded in photonic circuits that are individually addressable through spectral double resonance

Structural study on hole-doped superconductors Pr1-xSrxFeAsO

The structural details in Pr1-xSrxFeAsO (1111) superconducting system are analyzed using data obtained from synchrotron X-ray diffraction and the structural parameters are carefully studied as the system is moving from non-superconducting to hole-doped superconducting with the Sr concentration. Superconductivity emerges when the Sr doping amount reaches 0.221. The linear increase of the lattice constants proves that Sr is successfully introduced into the system and its concentration can accurately be determined by the electron density analyses. The evolution of structural parameters with Sr concentration in Pr1-xSrxFeAsO and their comparison to other similar structural parameters of the related Fe-based superconductors suggest that the interlayer space between the conducting As-Fe-As layer and the insulating Pr-O-Pr layer is important for improving Tc in the hole-doped (1111) superconductors, which seems to be different from electron-doped systems.Comment: 17 pages, 7 figures, 1 tabl

Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer

In previous work we have documented the nuclear translocation of endothelial NOS (eNOS) and its participation in combinatorial complexes with Estrogen Receptor Beta (ERβ) and Hypoxia Inducible Factors (HIFs) that determine localized chromatin remodeling in response to estrogen (E2) and hypoxia stimuli, resulting in transcriptional regulation of genes associated with adverse prognosis in prostate cancer (PCa). To explore the role of nuclear eNOS in the acquisition of aggressive phenotype in PCa, we performed ChIP-Sequencing on chromatin-associated eNOS from cells from a primary tumor with poor outcome and from metastatic LNCaP cells. We found that: 1. the eNOS-bound regions (peaks) are widely distributed across the genome encompassing multiple transcription factors binding sites, including Estrogen Response Elements. 2. E2 increased the number of peaks, indicating hormone-dependent eNOS re-localization. 3. Peak distribution was similar with/without E2 with ≈ 55% of them in extragenic DNA regions and an intriguing involvement of the 5′ domain of several miRs deregulated in PCa. Numerous potentially novel eNOS-targeted genes have been identified suggesting that eNOS participates in the regulation of large gene sets. The parallel finding of downregulation of a cluster of miRs, including miR-34a, in PCa cells associated with poor outcome led us to unveil a molecular link between eNOS and SIRT1, an epigenetic regulator of aging and tumorigenicity, negatively regulated by miR-34a and in turn activating eNOS. E2 potentiates miR-34a downregulation thus enhancing SIRT1 expression, depicting a novel eNOS/SIRT1 interplay fine-tuned by E2-activated ER signaling, and suggesting that eNOS may play an important role in aggressive PCa

Emergence of magnetic long-range order in frustrated pyrochlore Nd2_2Ir2_2O7_7 with metal-insulator transition

In this study, we performed powder neutron diffraction and inelastic scattering measurements of frustrated pyrochlore Nd$_2$Ir$_2$O$_7$, which exhibits a metal-insulator transition at a temperature $T_{\rm MI}$ of 33 K. The diffraction measurements revealed that the pyrochlore has an antiferromagnetic long-range structure with propagation vector $\vec{q}_{0}$ of (0,0,0) and that it grows with decreasing temperature below 15 K. This structure was analyzed to be of the all-in all-out type, consisting of highly anisotropic Nd$^{3+}$ magnetic moments of magnitude $2.3\pm0.4$$\mu_{\rm B}$, where $\mu_{\rm B}$ is the Bohr magneton. The inelastic scattering measurements revealed that the Kramers ground doublet of Nd$^{3+}$ splits below $T_{\rm MI}$. This suggests the appearance of a static internal magnetic field at the Nd sites, which probably originates from a magnetic order consisting of Ir$^{4+}$ magnetic moments. Here, we discuss a magnetic structure model for the Ir order and the relation of the order to the metal-insulator transition in terms of frustration.Comment: 6 pages, 1 table, 3 figure

miR-100-5p inhibition induces apoptosis in dormant prostate cancer cells and prevents the emergence of castration-resistant prostate cancer

Carcinoma of the prostate is the most common cancer in men. Treatment of aggressive prostate cancer involves a regiment of radical prostectomy, radiation therapy, chemotherapy and hormonal therapy. Despite significant improvements in the last decade, the treatment of prostate cancer remains unsatisfactory, because a significant fraction of prostate cancers develop resistance to multiple treatments and become incurable. This prompts an urgent need to investigate the molecular mechanisms underlying the evolution of therapy-induced resistance of prostate cancer either in the form of castration-resistant prostate cancer (CRPC) or transdifferentiated neuroendocrine prostate cancer (NEPC). By analyzing micro-RNA expression profiles in a set of patient-derived prostate cancer xenograft tumor lines, we identified miR-100-5p as one of the key molecular components in the initiation and evolution of androgen ablation therapy resistance in prostate cancer. In vitro results showed that miR-100-5p is required for hormone-independent survival and proliferation of prostate cancer cells post androgen ablation. In Silico target predictions revealed that miR-100-5p target genes are involved in key aspects of cancer progression, and are associated with clinical outcome. Our results suggest that mir-100-5p is a possible therapeutic target involved in prostate cancer progression and relapse post androgen ablation therapy

Arabidopsis RPT2a, 19S Proteasome Subunit, Regulates Gene Silencing via DNA Methylation

The ubiquitin/proteasome pathway plays a crucial role in many biological processes. Here we report a novel role for the Arabidopsis 19S proteasome subunit RPT2a in regulating gene activity at the transcriptional level via DNA methylation. Knockout mutation of the RPT2a gene did not alter global protein levels; however, the transcriptional activities of reporter transgenes were severely reduced compared to those in the wild type. This transcriptional gene silencing (TGS) was observed for transgenes under control of either the constitutive CaMV 35S promoter or the cold-inducible RD29A promoter. Bisulfite sequencing analysis revealed that both the transgene and endogenous RD29A promoter regions were hypermethylated at CG and non-CG contexts in the rpt2a mutant. Moreover, the TGS of transgenes driven by the CaMV 35S promoters was released by treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine, but not by application of the inhibitor of histone deacetylase Trichostatin A. Genetic crosses with the DNA methyltransferase met1 single or drm1drm2cmt3 triple mutants also resulted in a release of CaMV 35S transgene TGS in the rpt2a mutant background. Increased methylation was also found at transposon sequences, suggesting that the 19S proteasome containing AtRPT2a negatively regulates TGS at transgenes and at specific endogenous genes through DNA methylation