The Association Between Urinary Genistein Levels and Mortality Among Adults in the United States

BackgroundCurrent research on the relationship between phytoestrogens and mortality has been inconclusive. We explored the relationship between genistein, a phytoestrogen, and mortality in a large cohort representative of the United States population.Methods: Data were analyzed from the National Health and Nutrition Examination Survey (NHANES) from 1999–2010. Normalized urinary genistein (nUG) was analyzed as a log-transformed continuous variable and in quartiles. Mortality data were obtained from the National Death Index and matched to the NHANES participants. Survival analyses were conducted using the Kaplan-Meier analysis. Cox proportional hazard models were constructed for all-cause and cause-specific mortality without and with adjustment for potential confounding variables.Results: Of 11,497 participants, 944 died during the 64,443 person-years follow-up. The all-cause mortality rate was significantly lower in the lowest quartile compared to the highest quartile (incidence rate ratio = 2.14, 95%CI = 1.76 to 2.60). Compared to the lowest quartile, the highest quartile had significantly higher adjusted all-cause (HR = 1.57, 95%CI = 1.23 to 2.00), cardiovascular (HR = 1.67, 95%CI = 1.04 to 2.68), and other-cause (HR = 1.85, 95%CI = 1.33 to 2.57) mortality.Conclusion: We found that high urinary genistein levels were associated with increased risk of all-cause, cardiovascular, and other-cause mortality. This is contrary to popular opinion on the health benefits of genistein and needs further research

Enhancing Museum Narratives: Tales of Things and UCL’s Grant Museum

Emergent mobile technologies offer museum professionals new ways of engaging visitors with their collections. Museums are powerful learning environments and mobile technology can enable visitors to experience the narratives in museum objects and galleries and integrate them with their own personal reflections and interpretations. UCL‟s QRator project is exploring how handheld mobile devices and interactive digital labels can create new models for public engagement, personal meaning making and the construction of narrative opportunities inside museum spaces. The use of narrative in museums has long been recognised as a powerful communication technique to engage visitors and to explore the different kinds of learning and participation that result. Many museums make extensive use of narrative, or storytelling, as a learning, interpretive, and meaning making tool. This chapter discusses the potential for mobile technologies to connect museums to audiences through co-creation of narratives, taking the QRator project as a case study. The QRator project aims to stress the necessity of engaging visitors actively in the creation of their own interpretations of museum collections through the integration of QR codes, iPhone, iPad, and Android apps into UCL‟s Grant Museum of Zoology. Although this chapter will concentrate on mobile technology created for a natural history museum, issues of meaning making and narrative creation through mobile technology are applicable to any discipline. In the first instance, the concern is with the development of mobile media in museums followed by a discussion of the QRator project which stresses the opportunities and challenges in utilizing mobile technology to enhance visitor meaning making and narrative construction. Finally, this chapter discusses the extent to which mobile technologies might be used purposefully to transform institutional cultures, practices and relationships with visitors

Bibliothèques, ressources d’information et utilisateurs de ressources électroniques dans les sciences humaines

En 2005, l’université de Bangor décide qu’elle peut se passer de huit de ses bibliothécaires spécialisés car, à l’ère de Google, et avec la menace qui pèse sur les budgets, elle a du mal à justifier le financement de médiateurs pour aider les usagers de la bibliothèque à trouver les ressources nécessaires à leur travail [Curtis, 2005]. Cette action peut sembler extrême, mais elle suit pourtant un mode de pensée qui envahit graduellement le monde de l’information numérique jusqu’à sa conséquen..

Development of an automated detection algorithm for patient motion blur in digital mammograms

The purpose is to develop and validate an automated method for detecting image unsharpness caused by patient motion blur in digital mammograms. The goal is that such a tool would facilitate immediate re-taking of blurred images, which has the potential to reduce the number of recalled examinations, and to ensure that sharp, high-quality mammograms are presented for reading. To meet this goal, an automated method was developed based on interpretation of the normalized image Wiener Spectrum. A preliminary algorithm was developed using 25 cases acquired using a single vendor system, read by two expert readers identifying the presence of blur, location, and severity. A predictive blur severity score was established using multivariate modeling, which had an adjusted coefficient of determination, R2 =0.63±0.02, for linear regression against the average reader-scored blur severity. A heatmap of the relative blur magnitude showed good correspondence with reader sketches of blur location, with a Spearman rank correlation of 0.70 between the algorithmestimated area fraction with blur and the maximum of the blur area fraction categories of the two readers. Given these promising results, the algorithm-estimated blur severity score and heatmap are proposed to be used to aid observer interpretation. The use of this automated blur analysis approach, ideally with feedback during an exam, could lead to a reduction in repeat appointments for technical reasons, saving time, cost, potential anxiety, and improving image quality for accurate diagnosis.</p

Starshade Rendezvous Probe

The Starshade Rendezvous Probe Mission (https://smd-prod.s3.amazonaws.com/science-red/s3fs-public/atoms/files/Starshade2.pdf ) [1] will be the first space-based, high-contrast imaging mission with the potential to detect and characterize Earth-like planets in the habitable zone (HZ) around sunlike stars while at the same time exploring entire planetary systems about our nearest neighbors. Over the last two decades, astronomers have discovered and cataloged thousands of planets around other stars. Nevertheless, we have yet to find a planetary system like our own or to characterize discovered small planets to determine if they are similar to Earth. The next step in exploration is to image full planetary systems, including their HZs, and to obtain planetary spectra with enough sensitivity to determine if a planet is Earth-like. A space-based direct imaging mission to ultimately find and characterize other Earth-like planets is a long-term priority for space astrophysics [2, 3]

Photometric Observations of Three High Mass X-Ray Binaries and a Search for Variations Induced by Orbital Motion

We searched for long period variation in V-band, Ic-band and RXTE X-ray light curves of the High Mass X-ray Binaries (HMXBs) LS 1698 / RX J1037.5-5647, HD 110432 / 1H 1249-637 and HD 161103 / RX J1744.7-2713 in an attempt to discover orbitally induced variation. Data were obtained primarily from the ASAS database and were supplemented by shorter term observations made with the 24- and 40-inch ANU telescopes and one of the robotic PROMPT telescopes. Fourier periodograms suggested the existence of long period variation in the V-band light curves of all three HMXBs, however folding the data at those periods did not reveal convincing periodic variation. At this point we cannot rule out the existence of long term V-band variation for these three sources and hints of longer term variation may be seen in the higher precision PROMPT data. Long term V-band observations, on the order of several years, taken at a frequency of at least once per week and with a precision of 0.01 mag, therefore still have a chance of revealing long term variation in these three HMXBs.Comment: Accepted, RAA, May, 201

Pratiques documentaires numériques à l'université

Cet ouvrage, coordonné par Ghislaine Chartron, professeur au conservatoire des Arts et métiers (CNAM) et responsable de l'Institut national des techniques de la documentation (INTD). Annaïg Mahé, maître de conférences à l'Unité régionale de formation à l'information scientifique et technique (Urfist) de Paris et à l'école des Chartes, et Benoît Epron, maître de conférences à l'enssib, se propose d'explorer les pratiques documentaires dans l'enseignement supérieur et la recherche au moment clé du développement, voire de la croissance exponentielle de l'utilisation des outils numériques. À l'heure d'une maturité croissante de l'offre documentaire numérique et de ses potentiels dans tous les champs scientifiques, que connaissons-nous vraiment de la réalité des pratiques documentaires à l'université et dans les organismes de recherche ? Faire le point sur cette question fut l'objectif de la journée d'étude « Diversité des pratiques documentaires numériques dans les champs scientifiques » organisée à l'enssib en juillet 2009, qui a souhaité réunir un ensemble de travaux récents couvrant une large palette d'observations des pratiques dans la recherche et l'enseignement universitaire. Cette diversité concerne les méthodologies convoquées (quantitatives et qualitatives), les différents supports (notamment revues et ouvrages) et les différents champs disciplinaires (physique des hautes énergies, mathématiques et informatique, sciences de l'éducation, sciences politiques) : des mises en perspective plus transversales sont par ailleurs complémentaires. Les points de vue abordés sont internationaux