Assessing Athletes’ Risk for Developing the Female Athlete Triad at Two Mississippi Universities

Despite the health benefits associated with regular exercise, some female athletes experience menstrual dysfunction and low bone mineral density associated with low energy availability as a result of a high volume of exercise and inadequate caloric intake; these three components characterize the female athlete triad (FAT). Prior research explored the severity of the FAT, pre-season screenings, and nutrition intervention methods; however, current research regarding the relationship between the risk for developing the FAT and access to nutrition resources is lacking. The purpose of this study was to assess the risk of female athletes at two Mississippi universities for developing the FAT and determine if there is a correlation between risk for developing the FAT and access to nutrition resources such as a dietitian or peer education programs. Participants were recruited through an email sent to female athletes on eight teams at each university. An online survey incorporating the LEAF-Q and BSQ-16B regarding the athlete’s risk for developing the FAT and body satisfaction, respectively, was used to collect data. Participants were also asked about prior nutrition education history, knowledge of the FAT, and demographic questions. Results of this study show a significant difference (p = .007) in mean risk for FAT at The University of Mississippi (M = 8.12) as compared to The University of Southern Mississippi (M = 8.77). Participants in this study classified as at risk for the FAT (n = 12) were significantly more likely (χ 2 = 4.930, df = 1, p = .026) to have previous nutrition education by a registered dietitian. No significant differences were found between BSQ and LEAF-Q scores or LEAF-Q scores relationship with knowledge of the FAT and sport. Furthermore, appropriate nutrition resources for female athletes and athletes in general can provide v necessary information about adequate nutrition for performance and basic healthy body functions

Large scale anisotropies on halo infall

We perform a statistical analysis of the peculiar velocity field around dark matter haloes in numerical simulations. We examine different properties of the infall of material onto haloes and its relation to central halo shapes and the shape of the large scale surrounding regions (LSSR). We find that the amplitude of the infall velocity field along the halo shape minor axis is larger than that along the major axis. This is consistent for general triaxial haloes, and for both prolate and oblate systems. We also report a strong anisotropy of the velocity field along the principal axes of the LSSR. The infall velocity field around dark matter haloes reaches a maximum value along the direction of the minor axis of the LSSR, whereas along the direction of its major axis, it exhibits the smallest velocities. We also analyse the dependence of the matter velocity field on the local environment. The amplitude of the infall velocity at high local density regions is larger than at low local density regions. The velocity field tends to be more laminar along the direction towards the minor axis of the LSSR, where the mean ratio between flow velocity and velocity dispersion is of order unity and nearly constant up to scales of 15 Mpc/h. We also detect anisotropies in the outflowing component of the velocity field, showing a maximum amplitude along the surrounding LSSR major axis.Comment: 12 pages, 9 figures, accepted for publication in Monthly Notices of the Royal Astronomical Societ

The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination

OBJECTIVE To determine whether antimicrobial-impregnated textiles decrease the acquisition of pathogens by healthcare provider (HCP) clothing. DESIGN We completed a 3-arm randomized controlled trial to test the efficacy of 2 types of antimicrobial-impregnated clothing compared to standard HCP clothing. Cultures were obtained from each nurse participant, the healthcare environment, and patients during each shift. The primary outcome was the change in total contamination on nurse scrubs, measured as the sum of colony-forming units (CFU) of bacteria. PARTICIPANTS AND SETTING Nurses working in medical and surgical ICUs in a 936-bed tertiary-care hospital. INTERVENTION Nurse subjects wore standard cotton-polyester surgical scrubs (control), scrubs that contained a complex element compound with a silver-alloy embedded in its fibers (Scrub 1), or scrubs impregnated with an organosilane-based quaternary ammonium and a hydrophobic fluoroacrylate copolymer emulsion (Scrub 2). Nurse participants were blinded to scrub type and randomly participated in all 3 arms during 3 consecutive 12-hour shifts in the intensive care unit. RESULTS In total, 40 nurses were enrolled and completed 3 shifts. Analyses of 2,919 cultures from the environment and 2,185 from HCP clothing showed that scrub type was not associated with a change in HCP clothing contamination ( P =.70). Mean difference estimates were 0.118 for the Scrub 1 arm (95% confidence interval [CI], −0.206 to 0.441; P =.48) and 0.009 for the Scrub 2 rm (95% CI, −0.323 to 0.342; P =.96) compared to the control. HCP became newly contaminated with important pathogens during 19 of the 120 shifts (16%). CONCLUSIONS Antimicrobial-impregnated scrubs were not effective at reducing HCP contamination. However, the environment is an important source of HCP clothing contamination. TRIAL REGISTRATION Clinicaltrials.gov Identifier: NCT 02645214 Infect Control Hosp Epidemiol 2017;38:1147–115

Who Rpinted Shakespeare’s Fourth Folio?

According to Fredson Bowers, writing in Shakespeare Quarterly in 1951, we will never know the printer of that section "until we know everything there is to be learned about seventeenth-century types." 2 Bowers doubted we could ever list the full set of F4's printers because F4 was printed anonymously, and the volume left few clues about its printers. While George Watson Cole's 1909 "examination of the letterpress show[ed] that a copy of the Third Folio was apparently broken into three portions and sent to three different printers," Bowers himself only got as far as attributing the first of F4's three separately paginated parts. 3 The purpose of this note is to identify the other two printers involved in F4, one of whom, John Macock, was the printer whose shop was responsible for F4's Hamlet. Regrettably, this short note does not include everything there is to be learned about seventeenth-century types.

Pointing control for the SPIDER balloon-borne telescope

We present the technology and control methods developed for the pointing system of the SPIDER experiment. SPIDER is a balloon-borne polarimeter designed to detect the imprint of primordial gravitational waves in the polarization of the Cosmic Microwave Background radiation. We describe the two main components of the telescope's azimuth drive: the reaction wheel and the motorized pivot. A 13 kHz PI control loop runs on a digital signal processor, with feedback from fibre optic rate gyroscopes. This system can control azimuthal speed with < 0.02 deg/s RMS error. To control elevation, SPIDER uses stepper-motor-driven linear actuators to rotate the cryostat, which houses the optical instruments, relative to the outer frame. With the velocity in each axis controlled in this way, higher-level control loops on the onboard flight computers can implement the pointing and scanning observation modes required for the experiment. We have accomplished the non-trivial task of scanning a 5000 lb payload sinusoidally in azimuth at a peak acceleration of 0.8 deg/s$^2$, and a peak speed of 6 deg/s. We can do so while reliably achieving sub-arcminute pointing control accuracy.Comment: 20 pages, 12 figures, Presented at SPIE Ground-based and Airborne Telescopes V, June 23, 2014. To be published in Proceedings of SPIE Volume 914

Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behaviours

Although compulsive sexual behaviour (CSB) has been conceptualized as a "behavioural" addiction and common or overlapping neural circuits may govern the processing of natural and drug rewards, little is known regarding the responses to sexually explicit materials in individuals with and without CSB. Here, the processing of cues of varying sexual content was assessed in individuals with and without CSB, focusing on neural regions identified in prior studies of drug-cue reactivity. 19 CSB subjects and 19 healthy volunteers were assessed using functional MRI comparing sexually explicit videos with non-sexual exciting videos. Ratings of sexual desire and liking were obtained. Relative to healthy volunteers, CSB subjects had greater desire but similar liking scores in response to the sexually explicit videos. Exposure to sexually explicit cues in CSB compared to non-CSB subjects was associated with activation of the dorsal anterior cingulate, ventral striatum and amygdala. Functional connectivity of the dorsal anterior cingulate-ventral striatum-amygdala network was associated with subjective sexual desire (but not liking) to a greater degree in CSB relative to non-CSB subjects. The dissociation between desire or wanting and liking is consistent with theories of incentive motivation underlying CSB as in drug addictions. Neural differences in the processing of sexual-cue reactivity were identified in CSB subjects in regions previously implicated in drug-cue reactivity studies. The greater engagement of corticostriatal limbic circuitry in CSB following exposure to sexual cues suggests neural mechanisms underlying CSB and potential biological targets for interventions

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators

The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner (tm) s syndrome and in phenotypic differences between the sexes in health and disease

Marizomib for patients with newly diagnosed glioblastoma: a randomized phase 3 trial

Background: Standard treatment for patients with newly diagnosed glioblastoma includes surgery, radiotherapy (RT) and temozolomide (TMZ) chemotherapy (TMZ/RT→TMZ). The proteasome has long been considered a promising therapeutic target because of its role as a central biological hub in tumor cells. Marizomib is a novel pan-proteasome inhibitor that crosses the blood brain barrier. Methods: EORTC 1709/CCTG CE.8 was a multicenter, randomized, controlled, open label phase 3 superiority trial. Key eligibility criteria included newly diagnosed glioblastoma, age > 18 years and Karnofsky performance status > 70. Patients were randomized in a 1:1 ratio. The primary objective was to compare overall survival (OS) in patients receiving marizomib in addition to TMZ/RT→TMZ with patients receiving only standard treatment in the whole population, and in the subgroup of patients with MGMT promoter-unmethylated tumors. Results: The trial was opened at 82 institutions in Europe, Canada and the US. A total of 749 patients (99.9% of planned 750) were randomized. OS was not different between the standard and the marizomib arm (median 17 vs 16.5 months; HR=1.04; p=0.64). PFS was not statistically different either (median 6.0 vs. 6.3 months; HR=0.97; p=0.67). In patients with MGMT promoter-unmethylated tumors, OS was also not different between standard therapy and marizomib (median 14.5 vs 15.1 months, HR=1.13; p=0.27). More CTCAE grade 3/4 treatment-emergent adverse events were observed in the marizomib arm than in the standard arm. Conclusions: Adding marizomib to standard temozolomide-based radiochemotherapy resulted in more toxicity, but did not improve OS or PFS in patients with newly diagnosed glioblastoma