A new Method to Constrain the Iron Abundance from Cooling Delays in Coronal Loops

Recent observations with TRACE reveal that the time delay between the appearance of a cooling loop in different EUV temperature filters is proportional to the loop length, dt_12 ~ L. We model this cooling delay in terms of radiative loss and confirm this linear relationship theoretically. We derive an expression that can be used to constrain the coronal iron enhancement alpha_Fe=A_Fe^cor/A_Fe^Ph relative to the photospheric value as function of the cooling delay dt_12, flux F_2, loop width w, and filling factor q_w < 1. With this relation we find upper limits on the iron abundance enhancement of alpha_Fe < 4.8+/-1.7 for 10 small-scale nanoflare loops, and alpha_Fe < 1.4+/-0.4 for 5 large-scale loops, in the temperature range of T~1.0-1.4 MK. This result supports the previous finding that low-FIP elements, including Fe, are enhanced in the corona. The same relation constitutes also a lower limit for the filling factor, which is q_w > 0.2+/-0.1 and q_w > 0.8+/-0.2 for the two groups of coronal loops.Comment: 2 Figure

Hydrostatic Modeling of the Integrated Soft X-Ray and EUV Emission in Solar Active Regions

Many studies of the solar corona have shown that the observed X-ray luminosity is well correlated with the total unsigned magnetic flux. In this paper we present results from the extensive numerical modeling of active regions observed with the \textit{Solar and Heliospheric Observatory} (\textit{SOHO}) Extreme Ultraviolet Telescope (EIT), the \textit{Yohkoh} Soft X-ray Telescope (SXT), and the \textit{SOHO} Michelson Doppler Imager (MDI). We use potential field extrapolations to compute magnetic field lines and populate these field lines with solutions to the hydrostatic loop equations assuming steady, uniform heating. Our volumetric heating rates are of the form $\epsilon_H\sim \bar{B}^\alpha/L^\beta$, where $\bar{B}$ is the magnetic field strength averaged along a field line and $L$ is the loop length. Comparisons between the observed and simulated emission for 26 active regions suggest that coronal heating models that scale as $\epsilon_H\sim \bar{B}/L$ are in the closest argreement the observed emission at high temperatures. The field-braiding reconnection model of Parker, for example, is consistent with our results. We find, however, that the integrated intensities alone are insufficent to uniquely determine the parameterization of the volumetric heating rate. Visualizations of the emission are also needed. We also find that there are significant discrepancies between our simulation results and the lower temperature emission observed in the EIT channels.Comment: Accepted for publication in ApJ; Replaced problem figur

Genomic and proteomic profiling of responses to toxic metals in human lung cells.

Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expression following low-dose, acute exposures of cadmium, chromium, arsenic, nickel, or mitomycin C (MMC) in BEAS-2B human bronchial epithelial cells. Total RNA was isolated from cells exposed to 3 M Cd(II) (as cadmium chloride), 10 M Cr(VI) (as sodium dichromate), 3 g/cm2 Ni(II) (as nickel subsulfide), 5 M or 50 M As(III) (as sodium arsenite), or 1 M MMC for 4 hr. Expression changes were verified at the protein level for several genes. Only a small subset of genes was differentially expressed in response to each agent: Cd, Cr, Ni, As (5 M), As (50 M), and MMC each differentially altered the expression of 25, 44, 31, 110, 65, and 16 individual genes, respectively. Few genes were commonly expressed among the various treatments. Only one gene was altered in response to all four metals (hsp90), and no gene overlapped among all five treatments. We also compared low-dose (5 M, noncytotoxic) and high-dose (50 M, cytotoxic) arsenic treatments, which surprisingly, affected expression of almost completely nonoverlapping subsets of genes, suggesting a threshold switch from a survival-based biological response at low doses to a death response at high doses

Determining the Differential Emission Measure from EIS, XRT, and AIA

This viewgraph presentation determines the Differential Emission Measure (DEM) from the EUV Imaging Spectrometer (EIS), X Ray Telescope (XRT), and Atmospheric Imaging Array (AIA). Common observations with Fe, Si, and Ca EIS lines are shown along with observations with Al-mesh, Ti-poly Al-thick and Be-thick XRT filters. Results from these observations are shown to determine what lines and filters are important to better constrain the hot component

An Innovative Collaboration Of An Academic Institution With A Community Recovery Center

Research poster documenting the following project: The University of New England (UNE) collaborated with local recovery centers to create an interdisciplinary service learning partnership. Students in the Doctor of Physical Therapy (DPT) program explored the role of PT in Substance Use Disorder (SUD) recovery in an elective course. Three interactive PT related sessions were developed for the Intensive Outpatient Program (IOP) at Pinetree Recovery Center with the purpose of providing tools for physical activity to aid in the SUD recovery process.https://dune.une.edu/cecespring2020/1009/thumbnail.jp

The Magnetic Topology of Coronal Mass Ejection sources

In an attempt to test current initiation models of coronal mass ejections (CMEs), with an emphasis on the magnetic breakout model, we inspect the magnetic topology of the sources of 26 CME events in the context of their chromospheric and coronal response in an interval of approximately nine hours around the eruption onset. First, we perform current-free (potential) extrapolations of photospheric magnetograms to retrieve the key topological ingredients, such as coronal magnetic null points. Then we compare the reconnection signatures observed in the high cadence and high spatial resolution of the Transition Region And Coronal Explorer (TRACE) images with the location of the relevant topological features. The comparison reveals that only seven events can be interpreted in terms of the breakout model, which requires a multi-polar topology with pre-eruption reconnection at a coronal null. We find, however, that a larger number of events (twelve) can not be interpreted in those terms. No magnetic null is found in six of them. Seven other cases remain difficult to interpret. We also show that there are no systematic differences between the CME speed and flare energies of events under different interpretations.Comment: Accepted for publication in Ap

Determining the Relationship Between Seizure-Free Days and Other Predictors of Quality of Life in Patients with Dravet Syndrome and Their Carers from FFA Registration Studies

INTRODUCTION Dravet syndrome (DS) is a rare, lifelong epileptic encephalopathy characterised by frequent and severe seizures associated with premature mortality. Typically diagnosed in infancy, patients also experience progressive behavioural, motor-function and cognitive decline. Twenty percent of patients do not reach adulthood. Quality of life (QoL) is impaired for both patients and their carers. Reducing convulsive seizure frequency, increasing convulsive seizure-free days (SFDs) and improving patient/carer QoL are primary treatment goals in DS. This study explored the relationship between SFDs and patients' and carers' QoL to inform a cost-utility analysis of fenfluramine (FFA). METHODS In FFA registration studies, patients (or their carer proxies) completed the Paediatric QoL inventory (PedsQL). These data were mapped to EuroQol-5 Dimensions Youth version (EQ-5D-Y) to provide patient utilities. Carer utilities were collected using EQ-5D-5L and mapped to EQ-5D-3L to align patient and carer QoL on the same scale. Linear mixed-effects and panel regression models were tested and Hausman tests identified the most appropriate approach for each group. On this basis, a linear mixed-effects regression model was used to examine the relationships between patient EQ-5D-Y and clinically relevant variables (age, frequency of SFDs per 28 days, motor impairments and treatment dose). A linear panel regression model examined the relationship between SFDs and carer QoL. RESULTS After adjustment for age and underlying comorbidities, the patient regression model showed that SFDs per 28 days was a significant predictor of QoL. Each additional patient-SFD increased utility by 0.005 (p < 0.001). The carer linear panel model also showed that increasing SFDs per 28 days was a significant predictor of improved QoL. Each additional SFD increased carer utility by 0.014 (p < 0.001). CONCLUSION This regression framework highlights that SFDs are significantly correlated with both patients' and carers' QoL. Treatment with effective antiseizure medications that increase SFDs directly improves QoL for patients and their carers

Covalent bond shortening and distortion induced by pressurization of thorium, uranium, and neptunium tetrakis aryloxides

Covalency involving the 5f orbitals is regularly invoked to explain the reactivity, structure and spectroscopic properties of the actinides, but the ionic versus covalent nature of metal-ligand bonding in actinide complexes remains controversial. The tetrakis 2,6-di-tert-butylphenoxide complexes of Th, U and Np form an isostructural series of crystal structures containing approximately tetrahedral MO(4) cores. We show that up to 3 GPa the Th and U crystal structures show negative linear compressibility as the OMO angles distort. At 3 GPa the angles snap back to their original values, reverting to a tetrahedral geometry with an abrupt shortening of the M-O distances by up to 0.1 Å. The Np complex shows similar but smaller effects, transforming above 2.4 GPa. Electronic structure calculations associate the M-O bond shortening with a change in covalency resulting from increased contributions to the M-O bonding by the metal 6d and 5f orbitals, the combination promoting MO(4) flexibility at little cost in energy