440 research outputs found
A Note on the Instability of Lorentzian Taub-NUT-Space
I show that there are no SU(2)-invariant (time-dependent) tensorial
perturbations of Lorentzian Taub-NUT space. It follows that the spacetime is
unstable at the linear level against generic perturbations. I speculate that
this fact is responsible for so far unsuccessful attempts to define a sensible
thermodynamics for NUT-charged spacetimes.Comment: 13 pages, no figure
Electrodynamics of Abrikosov vortices: the Field Theoretical Formulation
Electrodynamic phenomena related to vortices in superconductors have been
studied since their prediction by Abrikosov, and seem to hold no fundamental
mysteries. However, most of the effects are treated separately, with no guiding
principle. We demonstrate that the relativistic vortex worldsheet in spacetime
is the object that naturally conveys all electric and magnetic information, for
which we obtain simple and concise equations. Breaking Lorentz invariance leads
to down-to-earth Abrikosov vortices, and special limits of these equations
include for instance dynamic Meissner screening and the AC Josephson relation.
On a deeper level, we explore the electrodynamics of two-form sources in the
absence of electric monopoles, in which the electromagnetic field strength
itself acquires the characteristics of a gauge field. This novel framework
leaves room for unexpected surprises.Comment: LaTeX, 23 pages, 5 figure
The Sensitivity of Harassment to Orbit: Mass Loss from Early-Type Dwarfs in Galaxy Clusters
We conduct a comprehensive numerical study of the orbital dependence of
harassment on early-type dwarfs consisting of 168 different orbits within a
realistic, Virgo-like cluster, varying in eccentricity and pericentre distance.
We find harassment is only effective at stripping stars or truncating their
stellar disks for orbits that enter deep into the cluster core. Comparing to
the orbital distribution in cosmological simulations, we find that the majority
of the orbits (more than three quarters) result in no stellar mass loss. We
also study the effects on the radial profiles of the globular cluster systems
of early-type dwarfs. We find these are significantly altered only if
harassment is very strong. This suggests that perhaps most early-type dwarfs in
clusters such as Virgo have not suffered any tidal stripping of stars or
globular clusters due to harassment, as these components are safely embedded
deep within their dark matter halo. We demonstrate that this result is actually
consistent with an earlier study of harassment of dwarf galaxies, despite the
apparent contradiction. Those few dwarf models that do suffer stellar stripping
are found out to the virial radius of the cluster at redshift=0, which mixes
them in with less strongly harassed galaxies. However when placed on
phase-space diagrams, strongly harassed galaxies are found offset to lower
velocities compared to weakly harassed galaxies. This remains true in a
cosmological simulation, even when halos have a wide range of masses and
concentrations. Thus phase-space diagrams may be a useful tool for determining
the relative likelihood that galaxies have been strongly or weakly harassed.Comment: 17 pages, 13 figures, Accepted to MNRAS 8th September 201
Stationary Metrics and Optical Zermelo-Randers-Finsler Geometry
We consider a triality between the Zermelo navigation problem, the geodesic
flow on a Finslerian geometry of Randers type, and spacetimes in one dimension
higher admitting a timelike conformal Killing vector field. From the latter
viewpoint, the data of the Zermelo problem are encoded in a (conformally)
Painleve-Gullstrand form of the spacetime metric, whereas the data of the
Randers problem are encoded in a stationary generalisation of the usual optical
metric. We discuss how the spacetime viewpoint gives a simple and physical
perspective on various issues, including how Finsler geometries with constant
flag curvature always map to conformally flat spacetimes and that the Finsler
condition maps to either a causality condition or it breaks down at an
ergo-surface in the spacetime picture. The gauge equivalence in this network of
relations is considered as well as the connection to analogue models and the
viewpoint of magnetic flows. We provide a variety of examples.Comment: 37 pages, 6 figure
Diet x genotype interactions in hepatic cholesterol and lipoprotein metabolism in Atlantic salmon (Salmo salar) in response to replacement of dietary fish oil with vegetable oil
The present study investigates the effects of genotype on responses to alternative feeds in Atlantic salmon. Microarray analysis of the liver transcriptome of two family groups, lean or fat, fed a diet containing either a fish oil (FO) or a vegetable oil (VO) blend indicated that pathways of cholesterol and lipoprotein metabolism might be differentially affected by the diet depending on the genetic background of the fish, and this was further investigated by real-time quantitative PCR, plasma and lipoprotein biochemical analysis. Results indicate a reduction in VLDL and LDL levels, with no changes in HDL, when FO is replaced by VO in the lean family group, whereas in fat fish fed FO, levels of apoB-containing lipoproteins were low and comparable with those fed VO in both family groups. Significantly lower levels of plasma TAG and LDL-TAG were measured in the fat group that was independent of diet, whereas plasma cholesterol was significantly higher in fish fed the FO diet in both groups. Hepatic expression of genes involved in cholesterol homeostasis, β-oxidation and lipoprotein metabolism showed relatively subtle changes. A significantly lower expression of genes considered anti-atherogenic in mammals (ATP-binding cassette transporter A1, apoAI, scavenger receptor class B type 1, lipoprotein lipase (LPL)b (TC67836) and LPLc (TC84899)) was found in lean fish, compared with fat fish, when fed VO. Furthermore, the lean family group appeared to show a greater response to diet composition in the cholesterol biosynthesis pathway, mediated by sterol-responsive element-binding protein 2. Finally, the presence of three different transcripts for LPL, with differential patterns of nutritional regulation, was demonstrated
An analysis of patterns of distribution of buprenorphine in the United States using ARCOS, Medicaid, and Medicare databases
Opioid overdose remains a problem in the United States despite pharmacotherapies, such as buprenorphine, in the treatment of opioid use disorder. This study characterized changes in buprenorphine use. Using the Drug Enforcement Administration\u27s ARCOS, Medicaid, and Medicare claims databases, patterns in buprenorphine usage in the United States from 2018 to 2020 were analyzed by examining percentage changes in total grams distributed and changes in grams per 100 K people in year-to-year usage based on ZIP code and state levels. For ARCOS from 2018 to 2019 and 2019 to 2020, total buprenorphine distribution in grams increased by 16.2% and 12.6%, respectively. South Dakota showed the largest statewide percentage increase in both 2018–2019 (66.1%) and 2019–2020 (36.7%). From 2018 to 2019, the ZIP codes ND-577 (156.4%) and VA-222 (−82.1%) had the largest and smallest percentage changes, respectively. From 2019 to 2020, CA-932 (250.2%) and IL-603 (−36.8%) were the largest and smallest, respectively. In both 2018–2019 and 2019–2020, PA-191 had the second highest increase in grams per 100K while OH-452 was the only ZIP code to remain in the top three largest decreases in grams per 100K in both periods. Among Medicaid patients in 2018, there was a nearly 2000-fold difference in prescriptions per 100k Medicaid enrollees between Kentucky (12 075) and Nebraska (6). Among Medicare enrollees in 2018, family medicine physicians and other primary care providers were the top buprenorphine prescribers. This study not only identified overall increases in buprenorphine availability but also pronounced state-level differences. Such geographic analysis can be used to discern which public policies and regional factors impact buprenorphine access
- …