The summertime plankton community at South Georgia (Southern Ocean): comparing the historical (1926/27) and modern (post 1995) records.

The earliest comprehensive plankton sampling programme in the Southern Ocean was 32 undertaken during the early part of last century by Discovery Investigations to gain a 33 greater scientific understanding of whale stocks and their summer feeding grounds. An 34 initial survey was carried out around South Georgia during December 1926 and January 35 1927 to describe the distribution of plankton during the summer, and to serve as a 36 baseline against which to compare future surveys. We have reanalysed phytoplankton and 37 zooplankton data from this survey and elucidated patterns of community distribution and 38 compared them with our recent understanding of the ecosystem based on contemporary 39 data. Analysis of Discovery data identified five groups of stations with characteristic 40 phytoplankton communities which were almost entirely consistent with the original 41 analysis conducted by Hardy and Gunther (1935). Major groupings were located at the 42 western end of the island and over the northern shelf where Corethron spp. were 43 dominant, and to the south and east where a more diverse flora included high abundances 44 of Nitzschia seriata. Major zooplankton-station groupings were located over the inner 45 shelf which was characterised by a high abundance of Drepanopus forcipatus and in 46 oceanic water >500 m deep that were dominated by Foraminifera, Oithona spp., 47 Ctenocalanus vanus, and Calanoides acutus. Stations along the middle and outer shelf 48 regions to the north and west, were characterised by low overall abundance. There was 49 some evidence that groupings of stations to the north of the island originated in different 50 water masses on either side of the Southern Antarctic Circumpolar Current Front, the 51 major frontal system in the deep ocean close to South Georgia. However, transect lines 52 during 1926/27 did not extend far enough offshore to sample this frontal region 53 3 adequately. Interannual variability of zooplankton abundance was assessed from stations 54 which were sampled repeatedly during 7 recent British Antarctic Survey cruises (1995-55 2005) to the region and following taxonomic harmonization and numerical 56 standardization (ind. m-3), a subset of 45 taxonomic categories of zooplankton (species 57 and higher taxa) from 1926/27, were compared with similar data obtained during the 58 BAS cruises using a linear model. Initially comparisons were restricted to BAS stations 59 that lay within 40 km of Discovery stations although a comparison was also made using 60 all available data. Despite low abundance values in 1926/27, in neither comparison did 61 Discovery data differ significantly from BAS data. Calculation of the percentage 62 similarity index across cruises did not reveal any systematic differences in species 63 composition between 1926/27 and the present. In the light of ocean warming trends, the 64 existence of more subtle changes in species composition is not ruled out, but an absence 65 of finely resolved time-series data make this impossible to determine

Classical Physics and Human Embodiment: The Role of Contemplative Practice in Integrating Formal Theory and Personal Experience in the Undergraduate Physics Curriculum

One of the objectives of the undergraduate physics curriculum is for students to become aware of the connections between the fundamental principles of classical physics and their personal experience. Nonetheless, numerous studies have shown that students’ awareness of such connections tends to deteriorate, sometimes substantially, following instruction. In this work, which constitutes the first analysis of the effects of contemplative practices on the learning experience in undergraduate physics courses, we present two practices aimed at integrating formal theory with students’ personal, embodied experience: a sensory meditation and a contemplative videography. In written reflections on their experiences with the practices, the students expressed suddenly becoming aware of countless manifestations of formal physics principles in their surroundings, in an important step toward establishing firm connections between the abstract and the experiential. Furthermore, the students reported experiencing a sense of physical embodiment, heightened sensory awareness, somatic relaxation, and mental stillness, in significant contrast to their typical experience. Students also described experiencing insight about the essential role of observation in the scientific endeavor, a reawakened sense of curiosity, an intrinsic motivation to understand the observed physical phenomena, and a deepened awareness of their cognitive and emotional processes

Knowledge brokerage and research utilisation: a discussion document prepared for the Australian Government Department of Health and Ageing

In mid 2009 the Australian Department of Health and Ageing (DoHA) funded the Australian Primary Health Care Research Institute (APHCRI) to undertake a project on Knowledge Brokerage (KB). The aim of the project was to develop a model through which APHCRI, DoHA and other key stakeholders could work together over the next iteration of APHCRI’s contract for translating research evidence into Australian primary health care systems and services. The KB model would support the Commonwealth’s health reform agenda through facilitating the dissemination of research findings to policy makers and enabling policy makers to pose research questions addressing their need for evidence to support policy development. The KB project undertaken by APHCRI has three components;  A comprehensive literature review  A workshop of key stakeholders to identify different models of KB, work towards identifying the key components of successful models and to devise a framework to support effective knowledge translation  A review of the processes used by APHCRI to fund research and the effectiveness of the synthesis and transfer of knowledge generated by APHCRI-funded research to date. This document reports on the outcomes of these three components and offers recommendations for future action.The research reported in this paper is a project of the Australian Primary Health Care Research Institute, which is supported by a grant from the Australian Government Department of Health and Ageing under the Primary Health Care Research, Evaluation and Development Strategy

No Such Thing as a Simple Flare: Substructure and Quasi-periodic Pulsations Observed in a Statistical Sample of 20 s Cadence TESS Flares

A 20 s cadence Transiting Exoplanet Survey Satellite monitoring campaign of 226 low-mass flare stars during Cycle 3 recorded 3792 stellar flares of &ge;1032 erg. We explore the time-resolved emission and substructure in 440 of the largest flares observed at high signal-to-noise, 97% of which released energies of &ge;1033 erg. We discover degeneracy present at 2 minute cadence between sharply peaked and weakly peaked flares is common, although 20 s cadence breaks these degeneracies. We better resolve the rise phases and find 46% of large flares exhibit substructure during the rise phase. We observe 49 candidate quasi-periodic pulsations (QPP) and confirm 17 at &ge;3&sigma;. Most of our QPPs have periods less than 10 minutes, suggesting short-period optical QPPs are common. We find QPPs in both the rise and decay phases of flares, including a rise-phase QPP in a large flare from Proxima Cen. We confirm that the Davenport et al. template provides a good fit to most classical flares observed at high cadence, although 9% favor Gaussian peaks instead. We characterize the properties of complex flares, finding 17% of complex flares exhibit "peak-bump" morphologies composed of a large, highly impulsive peak followed by a second, more gradual Gaussian peak. We also estimate the UVC surface fluences of temperate planets at flare peak and find one-third of 1034 erg flares reach the D90 dose of Deinococcus radiodurans in just 20 s in the absence of an atmosphere. &nbsp;</p

Psychophysiological Measures of Driver Distraction and Workload While Intoxicated

The crash risk associated with cell phone use while driving is acontentious issue. Many states are introducing Advanced Traveler InformationSystems (ATIS) that may be accessed with cell phones while driving (e.g., 511Traveler Information Services). In these contexts, there is a need for relevantresearch to determine the risk of cell phone use. This study compared driverperformance while conversing on a hands-free cell phone to conditions ofoperating common in-vehicle controls (e.g., radio, fan, air conditioning) andalcohol intoxication (BAC 0.08). In addition, the study examined the combinedeffects of being distracted and being intoxicated given that there may be a higherrisk of a crash if the driver engages in a combination of risk factors. Duringsimulated traffic scenarios, resource allocation was assessed through an eventrelatedpotential (ERP) novelty oddball paradigm. Intoxicated drivers were lessattentive to all stimuli and drivers engaged in secondary tasks had weakerresponses to unexpected novel sounds in brain regions associated with evaluativeprocessing. Drivers conversing on the cell phone and in-vehicle tasks while soberhad lower accuracy during the target tone task than intoxicated drivers notcompleting any secondary task

Racial/ethnic disparities in annual mammogram compliance among households in Little Haiti, Miami-Dade County, Florida

Abstract Introduction Breast cancer is the most commonly diagnosed cancer and the 2nd leading cause of cancer-related deaths among women in the U.S. Although routine screening via mammogram has been shown to increase survival through early detection and treatment of breast cancer, only 3 out of 5 women age ?40 are compliant with annual mammogram within the U.S. and the state of Florida. A breadth of literature exists on racial/ethnic disparities in compliance with mammogram; however, few such studies include data on individual Black subgroups, such as Haitians. This study assessed the association between race/ethnicity and annual mammogram compliance among randomly selected households residing in the largely Haitian community of Little Haiti, Miami-Dade County (MDC), Florida. Methods This study used cross-sectional, health data from a random-sample, population-based survey conducted within households residing in Little Haiti between November 2011 and December 2012 (n = 951). Mammogram compliance was defined as completion of mammogram by all female household members within the 12 months prior to the survey. The association between mammogram compliance and race/ethnicity was assessed using binary logistic regression models. Potential confounders were identified as factors that were conservatively associated with both compliance and race/ethnicity (P???0.20). Analyses were restricted to households containing at least 1 female member age ?40 (n = 697). Results Overall compliance with annual mammogram was 62%. Race/ethnicity was significantly associated with mammogram compliance (P = 0.030). Compliance was highest among non-Hispanic Black (NHB) households (75%), followed by Hispanic (62%), Haitian (59%), and non-Hispanic White (NHW) households (51%). After controlling for educational level, marital status, employment status, the presence of young children within the household, health insurance status, and regular doctor visits, a borderline significant disparity in mammogram compliance was observed between Haitian and NHB households (adjusted odds ratio = 1.63, P = 0.11). No other racial/ethnic disparities were observed. Discussion Compliance with annual mammogram was low among the surveyed households in Little Haiti. Haitian households underutilized screening by means of annual mammogram compared with NHB households, although this disparity was not significant. Compliance rates could be enhanced by conducting individualized, mammogram screening-based studies to identify the reasons behind low rate of compliance among households in this underserved, minority population

Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease: plasma concentrations exceed target levels, with drug accumulation in the most severe patients

Background: TKM-130803 is a specific anti-EBOV therapeutic comprised of two small interfering RNAs (siRNA) siLpol-2 and siVP35-2. The pharmacokinetics (PK) of these siRNAs was defined in Ebola virus disease (EVD) patients, with reference to efficacy (ET) and toxicology thresholds (TT). The relationship between PK and patient survival was explored. Methods: Pharmacokinetic (PK) and pharmacodynamic (PD) data were available for seven participants with EVD in Sierra Leone who received 0·3 mg/kg of TKM-130803 by intravenous infusion over 2 h daily for up to 7 days. Plasma concentration of siRNA was compared to survival at 14 days. PK data were fitted to two-compartment models then Monte Carlo simulated PK profiles were compared to ET (Cmax 0·04–0·57 ng/mL and mean concentration 1·43 ng/mL), and TT (3000 ng/mL). Findings: Viral loads (VL) were not significantly different at treatment onset or during treatment (p = 0·1) in subjects who survived or died. siRNA was in quantitative excess of virus genomes throughout treatment, but the 95% percentile exceeded TT. The maximum AUC for which the 95% percentile remained under TT was a continuous infusion of 0·15 mg/kg/day. Plasma concentration of both siRNAs were higher in subjects who died compared to subjects who survived (p&lt;0·025 both siRNAs). Interpretation: TKM-130803 was circulating in molar excess of circulating virus; a level considered needed for efficacy. Given extremely high viral loads it seems likely that the patients died because they were physiologically beyond the point of no return. Subjects who died exhibited some indication of impaired drug clearance, justifying caution in dosing strategies for such patients. This analysis has given a useful insight into the pharmacokinetics of the siRNA in the disease state and illustrates the value of designing PKPD studies into future clinical trials in epidemic situations. Funding: This work was supported by the Wellcome Trust of Great Britain (grant number 106491/Z/14/Z and 097997/Z/11/A) and by the EU FP7 project PREPARE (602525). The PHE laboratory was funded by the UK Department for International Development. The funders had no role in trial design, data collection or analysis. The views expressed are those of the authors and not necessarily those of Public Health England, the Department of Health, or the EU. Trial registration: Pan African Clinical Trials Registry PACTR201501000997429

Numerical Simulation of an EUV Coronal Wave Based on the February 13, 2009 CME Event Observed by STEREO

On 13 February 2009, a coronal wave -- CME -- dimming event was observed in quadrature by the STEREO spacecraft. We analyze this event using a three-dimensional, global magnetohydrodynamic (MHD) model for the solar corona. The numerical simulation is driven and constrained by the observations, and indicates where magnetic reconnection occurs between the expanding CME core and surrounding environment. We focus primarily on the lower corona, extending out to $3R_{\odot}$; this range allows simultaneous comparison with both EUVI and COR1 data. Our simulation produces a diffuse coronal bright front remarkably similar to that observed by STEREO/EUVI at 195 \AA. It is made up of \emph{two} components, and is the result of a combination of both wave and non-wave mechanisms. The CME becomes large-scale quite low ($<$ 200 Mm) in the corona. It is not, however, an inherently large-scale event; rather, the expansion is facilitated by magnetic reconnection between the expanding CME core and the surrounding magnetic environment. In support of this, we also find numerous secondary dimmings, many far from the initial CME source region. Relating such dimmings to reconnecting field lines within the simulation provides further evidence that CME expansion leads to the "opening" of coronal field lines on a global scale. Throughout the CME expansion, the coronal wave maps directly to the CME footprint. Our results suggest that the ongoing debate over the "true" nature of diffuse coronal waves may be mischaracterized. It appears that \emph{both} wave and non-wave models are required to explain the observations and understand the complex nature of these events

Moyo Vol. VIII N 1

Durica, Paul Editor\u27s Letter . 4. Thackeray, Alex. Postcard from the sXe . 5. Ward, Luc. Gods & Monsters (Hook-Up at Church) . 6. Anshuman, Karan. The India Nobody Knows (Mysticism and Misconceptions Revealed) . 8. Clements, Nina and Betsy Falconer. God as One of Us: Diverse Faiths Thrive at Denison . 10. Million, Chris. Splendor in the Fall (First Year Love Bittersweet) . 16. Grindstaff, Michelle. Beer by Night, Bed by Morning . 17. Hart, Madeline and Meredith Newman. Smoke Alarm: Reading This may Cause Lung Cancer, Heart Disease, Emphysema, and Complicate Pregnancy . 21. Almirall, Sara and Kirsten Werne. 20 Best Spots to Smoke on Campus . 22. Werne, Kirsten. An Interview with Painted Thin . 23. Burt, Kara. All in All, We\u27re Just Paper o the Wall (Dorm Art Clue to Denison Identity) . 25. Levine, Robert. Less Talk, Moore Rock (Thurston\u27 Sound Uplifts Soul) . 30. Almirall, R.R. Turtles . 31. Almirall, RR. The Warthog Feels He Has Much in Common With Paul Newman, Others Don\u27t . 20

Linking quality management to manufacturing strategy: an empirical investigation of customer focus practices

Quality management (QM) has often been advocated as being universally applicable to organizations. This is in contrast with the manufacturing strategy contingency approach of operations management (OM) which advocates internal and external consistency between manufacturing strategy choices. This article investigates, using the case-study method, whether customer focus practices—a distinctive subset of the whole set of QM practices—are contingent on a plant’s manufacturing strategy context. The study strongly suggests that customer focus practices are contingent on a plant’s manufacturing strategy and identifies mechanisms by which this takes place. The findings inform the implementation of QM programs