Strategic spatial planning in a devolving governance context: A study of Sheffield City Region

The UK government’s decision to formally abolish Regional Assemblies and Regional Spatial Strategies in 2011 produced a strategic planning ‘gap’ in the English planning system. The government concurrently embarked on a ‘devolution’ agenda that led to the formation of Local Enterprise Partnerships and Combined Authorities in city regions across England. These legislative and governance changes created a complex, evolving network of new governance spaces through which a plurality of voluntary strategic planning practices emerged, underpinned by a weakly-defined and under-resourced ‘Duty to Cooperate’. This research contributes enhanced understanding of how strategic spatial planning is approached in this devolving governance context, including the barriers to it, by presenting a detailed ethnographic study of Sheffield City Region; an area that currently lacks a strong, sub-regional planning narrative. Using qualitative research methods and a conceptual framework derived from historical and constructivist institutionalism, the research investigates how practices of strategic planning are shaped within this changing legislative, governance and territorial context. In Sheffield City Region, institutionalised structures created an environment that promoted informal cross-boundary collaborative practices, whilst resisting a formalised approach to strategic spatial plan-making. Although lacking the power and resources to implement it, planning officers promoted an ‘idealised’ version of strategic plan-making, derived from their historically embedded strategic spatial planning experiences. Elected members’ resistance of this approach was reinforced by ‘post-political’ forms of governance that developed within the Combined Authority, and increased austerity that promoted competition between local authorities. A combination of informal, formal and ‘in between’ governance spaces (and the interface between them) played an important role in enabling and constraining practices of strategic spatial planning and decision-making. The research highlights how Sheffield City Region’s multiple, overlapping spatial geographies, when ‘hardened’ as political territories, acquired a structuring power that further constrained strategic spatial planning at the city region scale

Covert and overt stuttering: Concepts and comparative findings

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Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy

BACKGROUND: Triglyceride concentrations are raised in pregnancy and are considered a key fetal fuel. Several gene variants are known to alter triglyceride concentrations, including those in the Apolipoprotein E (ApoE), Lipoprotein Lipase (LPL), and most recently, the Apolipoprotein AV (ApoAV) gene. However, less is known about how variants in these genes alter triglyceride concentrations in pregnancy or affect fetal growth. We aimed to determine the effect of the recently identified ApoAV gene on triglycerides in pregnancy and fetal growth. We assessed the role of two ApoAV haplotypes, defined by the C and W alleles of the -1131T>C and S19W polymorphisms, in 483 pregnant women and their offspring from the Exeter Family Study of Childhood Health. RESULTS: The -1131T>C and S19W variants have rare allele frequencies of 6.7% and 4.9% and are present in 13.4% and 9.7% of subjects respectively. In carriers of the -1131C and 19W alleles triglyceride concentrations were raised by 11.0% (1.98 mmol/ l(1.92 – 2.04) to 2.20 mmol/l (2.01 – 2.42), p = 0.035; and 16.2% (1.97 mmol/l (1.91 – 2.03) to 2.29 mmol/l (2.12 – 2.48), p < 0.001 respectively. There is nominally significant evidence that the -1131T>C variant is having an effect on maternal height (164.9 cm (164.3 – 165.5) to 167.0 cm (165.2 – 168.8), p = 0.029). There was no evidence that ApoAV genotype alters any other anthropometric measurements or biochemistries such as High Density Lipoprotein Cholesterol (HDL-C) or Low Density Lipoprotein Cholesterol (LDL-C). There is nominally significant evidence that the presence of a maternal -1131C variant alters fetal birth length (50.2 cm (50.0 – 50.4) to 50.9 cm (50.3 – 51.4), p = 0.022), and fetal birth crown-rump length (34.0 cm (33.8 – 34.1) to 34.5 cm (34.1 – 35.0), p = 0.023). There is no evidence that ApoAV genotype alters fetal birth weight or other fetal growth measurements. CONCLUSION: In conclusion variation in the ApoAV gene raises triglyceride concentrations in pregnancy, as well as normolipaemic states and there is preliminary evidence that it alters fetal growth parameters

Assessment of a Wind Turbine Blade Erosion Lifetime Prediction Model with Industrial Protection Materials and Testing Methods

Leading edge protection (LEP) coating systems are applied to protect turbine blade edges from rain erosion. The performance of a LEP system is assessed in an accelerated rain erosion test (RET) as a metric for industrial application, but these tests are expensive. Modelling methods are available to predict erosion, based on fundamental material properties, but there is a lack of validation. The Springer model (1976) is analysed in this work to assess it as a tool for using material fundamental properties to predict the time to failure in a rain erosion test. It has been applied, referenced and industry validated with important partial considerations. The method has been applied successfully for erosion damage by wear performance prediction when combined with prior material data from rain erosion test (RET), instead of obtaining it directly from fundamental properties measured separately as Springer proposed. The method also offers accurate predictions when coupled with modified numerical parameters obtained from experimental RET testing data. This research aims to understand the differences between the experimental data used by Springer and the current industry approach to rain erosion testing, and to determine how it may introduce inaccuracies into lifetime predictions of current LEP systems, since they are very different to those tested in the historic modelling validation. In this work, a review of the modelling is presented, allowing for the understanding of key issues of its computational implementation and the required experimental material characterisation. Modelling results are discussed for different original application issues and industry-related LEP configuration cases, offering the reader to interpret the limits of the performance prediction when considering the variation in material fundamental properties involved

Finite Temperature Theory of Metastable Anharmonic Potentials

The decay rate for a particle in a metastable cubic potential is investigated in the quantum regime by the Euclidean path integral method in semiclassical approximation. The imaginary time formalism allows one to monitor the system as a function of temperature. The family of classical paths, saddle points for the action, is derived in terms of Jacobian elliptic functions whose periodicity sets the energy-temperature correspondence. The period of the classical oscillations varies monotonically with the energy up to the sphaleron, pointing to a smooth crossover from the quantum to the activated regime. The softening of the quantum fluctuation spectrum is evaluated analytically by the theory of the functional determinants and computed at low $T$ up to the crossover. In particular, the negative eigenvalue, causing an imaginary contribution to the partition function, is studied in detail by solving the Lam\`{e} equation which governs the fluctuation spectrum. For a heavvy particle mass, the decay rate shows a remarkable temperature dependence mainly ascribable to a low lying soft mode and, approaching the crossover, it increases by a factor five over the predictions of the zero temperature theory. Just beyond the peak value, the classical Arrhenius behavior takes over. A similar trend is found studying the quartic metastable potential but the lifetime of the latter is longer by a factor ten than in a cubic potential with same parameters. Some formal analogies with noise-induced transitions in classically activated metastable systems are discussed.Comment: European Physical Journal B EDP Sciences, Societ`a Italiana di Fisica, Springer-Verlag 200

Higher PLIN5 but not PLIN3 content in isolated skeletal muscle mitochondria following acute in vivo contraction in rat hindlimb

Contraction-mediated lipolysis increases the association of lipid droplets and mitochondria, indicating an important role in the passage of fatty acids from lipid droplets to mitochondria in skeletal muscle. PLIN3 and PLIN5 are of particular interest to the lipid droplet–mitochondria interaction because PLIN3 is able to move about within cells and PLIN5 associates with skeletal muscle mitochondria. This study primarily investigated: 1) if PLIN3 is detected in skeletal muscle mitochondrial fraction; and 2) if mitochondrial protein content of PLIN3 and/or PLIN5 changes following stimulated contraction. A secondary aim was to determine if PLIN3 and PLIN5 associate and whether this changes following contraction. Male Long Evans rats (n = 21;age, 52 days; weight = 317 6 g) underwent 30 min of hindlimb stimulation (10 msec impulses, 100 Hz/3 sec at 10–20 V; train duration 100 msec). Contraction induced a ~50% reduction in intramuscular lipid content measured by oil red-O staining of red gastrocnemius muscle. Mitochondria were isolated from red gastrocnemius muscle by differential centrifugation and proteins were detected by western blotting. Mitochondrial PLIN5 content was ~1.6-fold higher following 30 min of contraction and PLIN3 content was detected in the mitochondrial fraction, and unchanged following contraction. An association between PLIN3 and PLIN5 was observed and remained unaltered following contraction. PLIN5 may play a role in mitochondria during lipolysis, which is consistent with a role in facilitating/regulating mitochondrial fatty acid oxidation. PLIN3 and PLIN5 may be working together on the lipid droplet and mitochondria during contraction-induced lipolysis