Devenir des nouveaux-nés opérés d'une occlusion intestinale néonatale

PARIS6-Bibl.Pitié-Salpêtrie (751132101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

La hiérarchisation des priorités d’autogestion à l’adolescence dans le cadre de la polypathologie allergique : une étude qualitative exploratoire

peer reviewe

Emergence of pollen food allergy syndrome in asthmatic children in Paris

International audienceBackgroundOver the last few decades, the level of pollen from birch and homologous trees has increased in parts of Europe. Sensitization to birch pollen allergens (principally Bet v 1) has been associated with food cross‐reactivity called pollen‐food‐allergy syndrome (PFAS).ObjectiveTo evaluate changes in allergic diseases due to IgE sensitization over 25 years in asthmatic children.MethodsThis was a cross‐sectional retrospective study conducted in Paris. We analyzed two cohorts of asthmatic children with similar characteristics explored between 1993‐1999 (old cohort=OC) and 2012‐2018 (recent cohort=RC).Results121 children were in the OC and 120 in the RC. An increase in sensitization to tree pollens was found especially for birch pollen which was 11.6% in the OC and 31% in the RC (p=0.0002). Allergic rhinitis prevalence was significantly higher in the RC than in the OC (96% vs 52%, respectively, p<0.0001). IgE‐mediated food allergy increased from 6% to 16% in the OC and RC, respectively, (p = 0.01) mainly due to PFAS. In the RC, a higher mean Bet v 1‐specific IgE level was observed in children with PFAS compared to children without (105.7 KU/L± 17.8 and 48.9 kU/L ± 15.7, respectively, p<0.05).ConclusionAllergic rhinitis and food allergy with tree‐pollen sensitization has increased in Paris over 25 years mainly due to PFAS. Environmental factors could be responsible for these modifications as described in literature

Children’s views on artificial intelligence and digital twins for the daily management of their asthma: a mixed-method study

International audienceNew technologies enable the creation of digital twin systems (DTS) combining continuous data collection from children’s home and artificial intelligence (AI)-based recommendations to adapt their care in real time. The objective was to assess whether children and adolescents with asthma would be ready to use such DTS. A mixed-method study was conducted with 104 asthma patients aged 8 to 17 years. The potential advantages and disadvantages associated with AI and the use of DTS were collected in semi-structured interviews. Children were then asked whether they would agree to use a DTS for the daily management of their asthma. The strength of their decision was assessed as well as the factors determining their choice. The main advantages of DTS identified by children were the possibility to be (i) supported in managing their asthma (ii) from home and (iii) in real time. Technical issues and the risk of loss of humanity were the main drawbacks reported. Half of the children (56%) were willing to use a DTS for the daily management of their asthma if it was as effective as current care, and up to 93% if it was more effective. Those with the best computer skills were more likely to choose the DTS, while those who placed a high value on the physician–patient relationship were less likely to do so. Conclusions: The majority of children were ready to use a DTS for the management of their asthma, particularly if it was more effective than current care. The results of this study support the development of DTS for childhood asthma and the evaluation of their effectiveness in clinical trials

Objectives for algorithmic decision-making systems in childhood asthma: Perspectives of children, parents, and physicians

Objectives To identify with children, parents and physicians the objectives to be used as parameters for algorithmic decision-making systems (ADMSs) adapting treatments in childhood asthma. Methods We first conducted a qualitative study based on semi-structured interviews to explore the objectives that children aged 8–17 years, their parents, and their physicians seek to achieve when taking/giving/prescribing a treatment for asthma. Following the grounded theory approach, each interview was independently coded by two researchers; reconciled codes were used to assess code frequency, categories were defined, and the main objectives identified. We then conducted a quantitative study based on questionnaires using these objectives to determine how children/parents/physicians ranked these objectives and whether their responses were aligned. Results We interviewed 71 participants (31 children, 30 parents and 10 physicians) in the qualitative study and identified seven objectives associated with treatment uptake and five objectives associated with treatment modalities. We included 291 participants (137 children, 137 parents, and 17 physicians) in the quantitative study. We found little correlation between child, parent, and physician scores for each of the objectives. Each child's asthma history influenced the choice of scores assigned to each objective by the child, parents, and physician. Conclusion The identified objectives are quantifiable and relevant to the management of asthma in the short and long term. They can therefore be incorporated as parameters for future ADMS. Shared decision-making seems essential to achieve consensus among children, parents, and physicians when choosing the weight to assign to each of these objectives

Usefulness of bronchoalveolar lavage in a French pediatric cohort with hypersensitivity pneumonitis

International audienceHypersensitivity pneumonitis (HP) is a rare interstitial lung disease in children, and very little data are available on the frequency, diagnosis, and outcomes of HP. In a pediatric cohort with HP, the characteristics of the CD4/CD8 lymphocyte ratio are often described as nonspecific

Health‐related quality of life in infants and children with interstitial lung disease

International audienc

Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort

International audienc