Chemical and sensory analysis of commercial Navel oranges in California.

Seven lots of commercially available Navel oranges grown in California were evaluated with flavoromic, metabolomic, sensory descriptive analysis, and consumer testing techniques to identify sensory and chemical drivers of liking. Eight identified chemical clusters related to numerous sensory attributes and consumer preferences. Differences in adult and child preferences led to the discovery of six consumer clusters (four adult and two child). Sweetness, overall flavor, sourness, fruity flavor, and juiciness were identified as the main sensory drivers of liking for the consumers. Fructose, glucose, and proline were among the compounds that best explained perceived sweetness while sourness was correlated with citrate and ascorbate. Perceived fruity flavor increased with higher concentrations of ethanol. We conclude that consumers differ in their preferences for Navel oranges and desire fruit that is higher in both sweetness and sourness

Undergraduate Research Journal, Volume 14

Table of Contents: The Myth of Chechen Radical Islam / by Jonathan Parker (p.1-8) -- Genre and the Perception of Massacre... / by Lauren Ferguson (p.9-18) -- Sentinel of Liberty: Captain America on the Home Front in WWII / by Carolyn McNamara (p.19-34) -- Embracing Myth in Mrs. Dalloway / by Aza Pace (p.35-48) -- Cannibalism and Witchcraft in The Tempest / by Kenneth F. Harlock (p.49-62) -- Evolutionary Game Models of Optimal Nuclear Weapons Strategies / by Christina Kent (p.63-82) -- Optimization for a Bio-Impedance Measurement System / by Matthew Normayle (p.83-94)Senate of College Council

Mitigating Greenhouse Gas and Ammonia Emissions from Swine Manure Management : A System Analysis

PMID: 28318241. We thank all our colleagues for their recommendations and support during this extensive study. Funding for the study was provided by the National Basic Research Program of China (2012CB417104), the Non-Profit Research Foundation for Agriculture (201303091), China Agriculture Research System (CARS-36), and UK-China Virtual Joint Centres on Nitrogen “N-Circle” and “CINAg” funded by the Newton Fund via UK BBSRC/NERC (BB/N013484/1 and BB/N013468/1, respectively).Peer reviewedPostprintPostprintPostprin

Expression and Functional Importance of Discoidin Domain Receptor 1 in Dentoalveolar Tissues

Collagen fibrils are abundant in all parts of the body and function to strengthen and support the extracellular framework in animal tissue. Collagen is a main component of fascia, cartilage, ligaments, tendons, bones and teeth. Like other connective tissues in the body, dentoalveolar tissues, including gingiva, dentin, cementum, periodontal ligament (PDL), and alveolar bone, are composed primarily of type I collagen as the major protein component. Discoidin domain receptors (DDR1 and DDR2) are receptors for several collagen types. They have been found to regulate collagen fibrillization and deposition in extracellular matrix (ECM) remodeling via tyrosine kinase activity, thereby modulating cell proliferation and affecting development of tissues. There have been limited studies on the expression and function of DDR1 during dentoalveolar development. In this study, we defined the expression patterns of DDR1 in dentoalveolar tissues and investigated the functional importance of DDR1 in tooth development using a DDR1-deficient mouse model. Expression of DDR1 was identified in the epithelial tissues including the enamel organ and gingiva, but expression was not detected in any ectomesenchymal cells of the pulp, dentin, or periodontium. Conversely, DDR2 expression was identified in odontoblasts and osteoblasts. Radiography revealed no major differences in Ddr1-/- vs. WT dentoalveolar structures; however, Ddr1-/- mandibles featured defective condyles and abnormal subchondral bone structure. Histomorphometry measurements of oral, dental, and periodontal tissues did not identify significant anatomic differences, including gingival epithelium. These studies indicate distinct expression patterns for DDR1 and DDR2, suggesting dissimilar functions in dentoalveolar tissues. Our findings indicate signs of osteoarthritis in the DDR1-deficient condylar process and periodontitis in the 2nd and 3rd molars of the mandible. This study suggests the importance of DDR1 in arthritis and periodontal function and may potentially inform disease mechanisms, wound healing, novel dental and periodontal therapies, and reconstruction of bone for dental and orthopedic purposes.No embargoAcademic Major: Biomedical Engineerin

The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering.

We evaluated the effect of electron beam (E-beam) sterilization (25 kGy, ISO 11137) on the degradation of β-tricalcium phosphate/polycaprolactone (β-TCP/PCL) composite filaments of various ratios (0:100, 20:80, 40:60, and 60:40 TCP:PCL by mass) in a rat subcutaneous model for 24 weeks. Volumes of the samples before implantation and after explantation were measured using micro-computed tomography (micro-CT). The filament volume changes before sacrifice were also measured using a live micro-CT. In our micro-CT analyses, there was no significant difference in volume change between the E-beam treated groups and non-E-beam treated groups of the same β-TCP to PCL ratios, except for the 0% β-TCP group. However, the average volume reduction differences between the E-beam and non-E-beam groups in the same-ratio samples were 0.76% (0% TCP), 3.30% (20% TCP), 4.65% (40% TCP), and 3.67% (60% TCP). The E-beam samples generally had more volume reduction in all experimental groups. Therefore, E-beam treatment may accelerate degradation. In our live micro-CT analyses, most volume reduction arose in the first four weeks after implantation and slowed between 4 and 20 weeks in all groups. E-beam groups showed greater volume reduction at every time point, which is consistent with the results by micro-CT analysis. Histology results suggest the biocompatibility of TCP/PCL composite filaments

Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially significant source of cellular reactive oxygen species (ROS). Recent studies suggest that levels of ROS generated as a byproduct of oxidative folding rival those produced by mitochondrial respiration. Mechanisms that protect cells against oxidant accumulation within the ER have begun to be elucidated yet many questions still remain regarding how cells prevent oxidant-induced damage from ER folding events. Here we report a new role for a central well-characterized player in ER homeostasis as a direct sensor of ER redox imbalance. Specifically we show that a conserved cysteine in the lumenal chaperone BiP is susceptible to oxidation by peroxide, and we demonstrate that oxidation of this conserved cysteine disrupts BiP's ATPase cycle. We propose that alteration of BiP activity upon oxidation helps cells cope with disruption to oxidative folding within the ER during oxidative stress.Cornell UniversityNational Institutes of Health (U.S.) (Grant GM46941

Analyzing BGP Instances in Maude

Analyzing Border Gateway Protocol (BGP) instances is a crucial stepin the design and implementation of safe BGP systems. Today, the analysis is amanual and tedious process. Researchers study the instances by manually constructingexecution sequences, hoping to either identify an oscillation or showthat the instance is safe by exhaustively examining all possible sequences. Wepropose to automate the analysis by using Maude, a tool based on rewriting logic.We have developed a library specifying a generalized path vector protocol, andmethods to instantiate the library with customized routing policies. Protocols canbe analyzed automatically by Maude, once users provide specifications of thenetwork topology and routing policies. Using our Maude library, protocols orpolicies can be easily specified and checked for problems. To validate our approach,we performed safety analysis of well-known BGP instances and actualrouting configurations

Ultrafast manipulation of mirror domain walls in a charge density wave

Domain walls (DWs) are singularities in an ordered medium that often host exotic phenomena such as charge ordering, insulator-metal transition, or superconductivity. The ability to locally write and erase DWs is highly desirable, as it allows one to design material functionality by patterning DWs in specific configurations. We demonstrate such capability at room temperature in a charge density wave (CDW), a macroscopic condensate of electrons and phonons, in ultrathin 1T-TaS$_2$. A single femtosecond light pulse is shown to locally inject or remove mirror DWs in the CDW condensate, with probabilities tunable by pulse energy and temperature. Using time-resolved electron diffraction, we are able to simultaneously track anti-synchronized CDW amplitude oscillations from both the lattice and the condensate, where photo-injected DWs lead to a red-shifted frequency. Our demonstration of reversible DW manipulation may pave new ways for engineering correlated material systems with light