SN 1987A's Circumstellar Envelope, II: Kinematics of the Three Rings and the Diffuse Nebula

We present several different measurements of the velocities of structures within the circumstellar envelope of SN 1987A, including the inner, equatorial ring (ER), outer rings (ORs), and the diffuse nebulosity at radii < 5 pc, based on CTIO 4m and HST data. A comparison of STIS and WFPC2 [N II]6583 loci for the rings show that the ER is expanding in radius at 10.5+-0.3 km/s, with the northern OR expanding along the line of sight at about 26 km/s, and for the southern OR, about 23 km/s. Similar results are found with CTIO 4m data. Accounting for inclination, the best fit to all data show both ORs with an expansion from the SN of 26 km/s. The ratio of the ER to OR velocities is nearly equal to the ratio of ER to OR radii, so the rings are roughly homologous, all having kinematic ages corresponding to about 20,000 yr before the SN explosion. This makes previously reported, large compositional differences between the ER and ORs difficult to understand. Additionally, a grid of longslit 4m/echelle spectra centered on the SN shows two velocity components over a region roughly coextensive with the outer circumstellar envelope extending about 5 pc (20 arcsec) from the SN. One component is blueshifted and the other redshifted from the SN centroid by about 10 km/s each. These features may represent a bipolar flow expanding from the SN, in which the ORs are propelled 10-15 km/s faster than that of the surrounding envelope into which they propogate. The kinematic timescale for the entire nebula is at least about 350,000 yr. The kinematics of these various structures constrain possible models for the evolution of the progenitor and its formation of a mass loss nebula.Comment: 25 pages AASTeX text plus 12 figures. ApJ, in pres

The implications of K-Ar glauconite dating of the Diest Formation on the paleogeography of the Upper Miocene in Belgium

The glauconite-rich Diest Formation in central and north Belgium contains sands in the Campine subsurface and the hilly Hageland area that can be distinguished from each other. The Hageland Diest Sands member contains no stratigraphically relevant fossils while in the Campine subsurface dinoflagellate cysts are common and show a stratigraphic range covering the entire Tortonian stage. K-Ar dates were determined for glauconite from 13 selected samples spread over both areas. A glauconite date corresponding to the earliest Tortonian indicates newly formed glauconite was incorporated into a greensand at the base of the Diest Formation in the central Campine area. All other dates point at reworked glauconite and can be organized in two groups, one reflecting a Burdigalian age and another reflecting a Langhian age. These data and the thickness and glauconite content of the Diest Formation imply massive reworking of older Miocene deposits. The paleogeographic implications of these data lead to the tentative recognition of two Tortonian sedimentary sequences. An older one corresponding to dinoflagellate biochron DN8 comprises the Deurne Member, part of the Dessel Member, the Hageland Diest member, the eastern Campine Diest member and some basal sands of the Diest Formation in the central Campine. A younger sequence corresponding to dinoilagellate biochrons DN9 and 10 was strongly influenced by the prograding proto-Rhine delta front in the Roer Valley Graben to the northeast. The subsiding Campine basin was filled from east to west during this second cycle

Physical Conditions in Circumstellar Gas surrounding SN 1987A 12 Years After Outburst

Two-dimensional spectra of Supernova 1987A were obtained on 1998 November 14-15 (4282 days after outburst) with the Space Telescope Imaging Spectrograph (STIS) on board the Hubble Space Telescope (HST). The slit sampled portions of the inner circumstellar ring at the east and west ansae as well as small sections of both the northern and southern outer rings. The temperature and density at these locations are estimated by nebular analysis of [N II], [O III], and [S II] emission line ratios, and with time-dependent photoionization/recombination models. The results from these two methods are mutually consistent. The electron density in the inner ring is ~ 4000 cm-3 for S II, with progressively lower densities for N II and O III. The electron temperatures determined from [N II] and [O III] line ratios are ~11,000 K and \~22,000 K, respectively. These results are consistent with evolutionary trends in the circumstellar gas from similar measurements at earlier epochs. We find that emission lines from the outer rings come from gas of lower density (n_e \la 2000 cm-3) than that which emits the same line in the inner ring. The N/O ratio appears to be the same in all three rings. Our results also suggest that the CNO abundances in the northern outer ring are the same as in the inner ring, contrary to earlier results of Panagia et al. (1996). Physical conditions in the southern outer ring are less certain because of poorer signal-to-noise data. The STIS spectra also reveal a weak Ha emission redshifted by ~100 km s-1 at p.a. 103\arcdeg that coincides with the recently discovered new regions that are brightening (Lawrence et al. 2000). This indicates that the shock interaction in the SE section of the inner ring commenced over a year before it became apparent in HST images.Comment: 25 pages, 6 figures, to appear in December 1, 2000 Astrophysical Journa

Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial.

BACKGROUND: For many years, first-line treatment for locally advanced or metastatic soft-tissue sarcoma has been doxorubicin. This study compared gemcitabine and docetaxel versus doxorubicin as first-line treatment for advanced or metastatic soft-tissue sarcoma. METHODS: The GeDDiS trial was a randomised controlled phase 3 trial done in 24 UK hospitals and one Swiss Group for Clinical Cancer Research (SAKK) hospital. Eligible patients had histologically confirmed locally advanced or metastatic soft-tissue sarcoma of Trojani grade 2 or 3, disease progression before enrolment, and no previous chemotherapy for sarcoma or previous doxorubicin for any cancer. Patients were randomly assigned 1:1 to receive six cycles of intravenous doxorubicin 75 mg/m(2) on day 1 every 3 weeks, or intravenous gemcitabine 675 mg/m(2) on days 1 and 8 and intravenous docetaxel 75 mg/m(2) on day 8 every 3 weeks. Treatment was assigned using a minimisation algorithm incorporating a random element. Randomisation was stratified by age (≤18 years vs >18 years) and histological subtype. The primary endpoint was the proportion of patients alive and progression free at 24 weeks in the intention-to-treat population. Adherence to treatment and toxicity were analysed in the safety population, consisting of all patients who received at least one dose of their randomised treatment. The trial was registered with the European Clinical Trials (EudraCT) database (no 2009-014907-29) and with the International Standard Randomised Controlled Trial registry (ISRCTN07742377), and is now closed to patient entry. FINDINGS: Between Dec 3, 2010, and Jan 20, 2014, 257 patients were enrolled and randomly assigned to the two treatment groups (129 to doxorubicin and 128 to gemcitabine and docetaxel). Median follow-up was 22 months (IQR 15·7-29·3). The proportion of patients alive and progression free at 24 weeks did not differ between those who received doxorubicin versus those who received gemcitabine and docetaxel (46·3% [95% CI 37·5-54·6] vs 46·4% [37·5-54·8]); median progression-free survival (23·3 weeks [95% CI 19·6-30·4] vs 23·7 weeks [18·1-20·0]; hazard ratio [HR] for progression-free survival 1·28, 95% CI 0·99-1·65, p=0·06). The most common grade 3 and 4 adverse events were neutropenia (32 [25%] of 128 patients who received doxorubicin and 25 [20%] of 126 patients who received gemcitabine and docetaxel), febrile neutropenia (26 [20%] and 15 [12%]), fatigue (eight [6%] and 17 [14%]), oral mucositis (18 [14%] and two [2%]), and pain (ten [8%] and 13 [10%]). The three most common serious adverse events, representing 111 (39%) of all 285 serious adverse events recorded, were febrile neutropenia (27 [17%] of 155 serious adverse events in patients who received doxorubicin and 15 [12%] of 130 serious adverse events in patients who received gemcitabine and docetaxel, fever (18 [12%] and 19 [15%]), and neutropenia (22 [14%] and ten [8%]). 154 (60%) of 257 patients died in the intention-to-treat population: 74 (57%) of 129 patients in the doxorubicin group and 80 (63%) of 128 in the gemcitabine and docetaxel group. No deaths were related to the treatment, but two deaths were due to a combination of disease progression and treatment. INTERPRETATION: Doxorubicin should remain the standard first-line treatment for most patients with advanced soft-tissue sarcoma. These results provide evidence for clinicians to consider with their patients when selecting first-line treatment for locally advanced or metastatic soft-tissue sarcoma. FUNDING: Cancer Research UK, Sarcoma UK, and Clinical Trial Unit Kantonsspital St Gallen

Caesium incorporation and retention in illite interlayers

Radioactive caesium (chiefly 137Cs) is a major environmental pollutant. The mobility of Cs in temperate soils is primarily controlled by sorption onto clay minerals, particularly the frayed edges of illite interlayers. This paper investigates the adsorption of Cs to illite at the molecular scale, over both the short and long term. Transmission electron microscopy (TEM) images showed that after initial absorption into the frayed edges, Cs migrated into the illite interlayer becoming incorporated within the mineral structure. Caesium initially exchanged with hydrated Ca at the frayed edges, causing them to collapse. This process was irreversible as Cs held in the collapsed interlayers was not exchangeable with Ca. Over the long term Cs did not remain at the edge of the illite crystals, but diffused into the interlayers by exchange with K. Results from extended X-ray absorption fine structure spectroscopy (EXAFS) and density functional theory modelling confirmed that Cs was incorporated into the illite interlayer and revealed its bonding environment

Learning to Translate with Products of Novices: A Suite of Open-Ended Challenge Problems for Teaching MT

Machine translation (MT) draws from several different disciplines, making it a complex subject to teach. There are excellent pedagogical texts, but problems in MT and current algorithms for solving them are best learned by doing. As a centerpiece of our MT course, we devised a series of open-ended challenges for students in which the goal was to improve performance on carefully constrained instances of four key MT tasks: alignment, decoding, evaluation, and reranking. Students brought a diverse set of techniques to the problems, including some novel solutions which performed remarkably well. A surprising and exciting outcome was that student solutions or their combinations fared competitively on some tasks, demonstrating that even newcomers to the field can help improve the state-ofthe-art on hard NLP problems while simultaneously learning a great deal. The problems, baseline code, and results are freely available.

Effectiveness of student response systems in terms of learning environment, attitudes and achievement

In order to investigate the effectiveness of using Student Response Systems (SRS) among grade 7 and 8 science students in New York, the How Do You Feel About This Class? (HDYFATC) questionnaire was administered to 1097 students (532 students did use SRS and 565 students who did not use SRS). Data analyses attested to the sound factorial validity and internal consistency reliability of the HDYFATC, as well as its ability to differentiate between the perceptions of students in different classrooms. Very large differences between users and non-users of SRS, ranging from 1.17 to 2.45 standard deviations for various learning environment scales, attitudes and achievement, supported the efficacy of using SRS

CONTROL MECHANISMS FOR GENERATORS IN ICON

Generators, or expressions capable of producing a sequence of results during evaluation, are found in one form or another in a number of programming languages. The use of generators has been limited by a lack of understanding of their operation. Control structures for generating expressions are usually patterned after the control structures found in conventional language designs. A notation for describing the static aspects of generators is presented in this dissertation. This notation is used to describe the operation of the generator-based control structures in Icon and to introduce several novel control structures based upon generator evaluation. Co-expressions are introduced as the expression-level equivalent of coroutines, and combined with generators to provide a powerful programming facility. Finally, machine and language independent models for implementation of goal-directed evaluation and co-expressions are presented