PCN21 FIRST-LINE BEVACIZUMAB-BASED THERAPY VERSUS PEMETREXED + CISPLATIN FOR THE TREATMENT OF ADVANCED ADENOCARCINOMA NONSQUAMOUS NON-SMALL CELL LUNG CANCER: INDIRECT COMPARISON APPLYING REAL-LIFE OUTCOMES

Digitalitzat per Artypla

Water Use of Asiatic Wild Asses in the Mongolian Gobi

Water is a key resource for most large bodied mammals in the world’s arid areas. With the growing human population, access to water for wildlife often becomes compromised. Equids are typical inhabitants of semi-arid to arid rangelands and need regular access to fresh water. However, their water needs are difficult to study under free-ranging conditions. In this study we investigated Asiatic wild ass (Equus hemionus) use of permanent water points in the Great Gobi B Strictly Protected Area (SPA) in south-western Mongolia. We combined observational data from one specific water point with high frequency GPS location data from one radio-collared Asiatic wild ass mare. Observations and GPS data revealed that wild asses come to drink during all 24-hours of the day without an apparent diurnal pattern. The majority of wild asses came to the water point alone or in small groups. Other ungulates were largely ignored by wild asses, but the arrival of humans and their transportation devices almost always resulted in flight behavior. The monthly drinking frequency varied from every 1.5 to 2.2 days during the hot and dry season in June and August to every 2.3 to 3.8 days in April, May and September. Longer intervals between successive visits to permanent water points may explain why Asiatic wild asses can make use of pastures further away from water than sympatric Przewalski’s horses (Equus ferus przewalskii). The lack of a clear diurnal pattern suggests that there is no specific time window in which wild ass are particularly vulnerable to disturbances at water points. However the high disturbance potential of humans and their transportation devices makes it desirable to restrict human impact at water points by re-routing transportation routes, or requiring a minimum distance from water for herder camps and wildlife viewing facilities

Water Use of Asiatic Wild Asses in the Mongolian Gobi

Water is a key resource for most large bodied mammals in the world’s arid areas. With the growing human population, access to water for wildlife often becomes compromised. Equids are typical inhabitants of semi-arid to arid rangelands and need regular access to fresh water. However, their water needs are difficult to study under free-ranging conditions. In this study we investigated Asiatic wild ass (Equus hemionus) use of permanent water points in the Great Gobi B Strictly Protected Area (SPA) in south-western Mongolia. We combined observational data from one specific water point with high frequency GPS location data from one radio-collared Asiatic wild ass mare. Observations and GPS data revealed that wild asses come to drink during all 24-hours of the day without an apparent diurnal pattern. The majority of wild asses came to the water point alone or in small groups. Other ungulates were largely ignored by wild asses, but the arrival of humans and their transportation devices almost always resulted in flight behavior. The monthly drinking frequency varied from every 1.5 to 2.2 days during the hot and dry season in June and August to every 2.3 to 3.8 days in April, May and September. Longer intervals between successive visits to permanent water points may explain why Asiatic wild asses can make use of pastures further away from water than sympatric Przewalski’s horses (Equus ferus przewalskii). The lack of a clear diurnal pattern suggests that there is no specific time window in which wild ass are particularly vulnerable to disturbances at water points. However the high disturbance potential of humans and their transportation devices makes it desirable to restrict human impact at water points by re-routing transportation routes, or requiring a minimum distance from water for herder camps and wildlife viewing facilities

Fast Succinct Retrieval and Approximate Membership Using Ribbon

A retrieval data structure for a static function f: S → {0,1}^r supports queries that return f(x) for any x ∈ S. Retrieval data structures can be used to implement a static approximate membership query data structure (AMQ), i.e., a Bloom filter alternative, with false positive rate 2^{-r}. The information-theoretic lower bound for both tasks is r|S| bits. While succinct theoretical constructions using (1+o(1))r|S| bits were known, these could not achieve very small overheads in practice because they have an unfavorable space-time tradeoff hidden in the asymptotic costs or because small overheads would only be reached for physically impossible input sizes. With bumped ribbon retrieval (BuRR), we present the first practical succinct retrieval data structure. In an extensive experimental evaluation BuRR achieves space overheads well below 1% while being faster than most previously used retrieval data structures (typically with space overheads at least an order of magnitude larger) and faster than classical Bloom filters (with space overhead ≥ 44%). This efficiency, including favorable constants, stems from a combination of simplicity, word parallelism, and high locality. We additionally describe homogeneous ribbon filter AMQs, which are even simpler and faster at the price of slightly larger space overhead

Energy Modelling on the Alpine Bow

The Alpine bow has a great potential for renewable energy (RE) development. At the same time, wildlife in Alpine areas is at risk and has to be protected. More of 40% of the Alpine area is covered by protected areas. They vary in definition and level of protection regarding their category, region, and country. Therefore, some of those protected areas may be suited for the development of bioenergy whereas others may be more suited for the development of hydropower. Using a precise classification of those protected areas, and assuming the correct protection level the techno-economic model, spatial explicit, BeWhere, will identify the potential from hydropower, bioenergy, wind and solar power while balancing the ecosystems services in the Alps. The model is based on the minimization of the whole supply chain, starting from the collection of the feedstock to the delivery of the final product to the consumers in the Alps and in the major cities outside the Alps. Access to the site is a determinant issue to build a new power plant in the Alps, therefore the model uses a detailed road network for the transport of the feedstock and accessibility, as well as a map of the high voltage power line. The future RE production plants will be installed if the production cost is competitive enough against fossil fuel based power and heat. The model will then provide the optimal locations, numbers, technologies, and capacities for hydropower stations, bioenergy production plants, solar PV fields and wind parks, together with their corresponding costs and emissions. A series of scenarios will be carried out varying the fossil fuel price, the carbon cost and the level of protection of the environment. For each of the scenarios, the RE potential, production cost, and emission reductions will be assessed. The results will provide key indications to the stakeholders and the policymakers on the consequences of protecting the environment and the development of RE production

Societal savings in patients with advanced non-squamous non-small-cell lung cancer receiving bevacizumab-based versus non-bevacizumab-based treatments in France, Germany, Italy, and Spain

BACKGROUND: The purpose of this study was to investigate the savings accrued using bevacizumab-based treatment for non-small-cell lung cancer from the societal perspective, taking only public costs into account, in France, Germany, Italy, and Spain. METHODS: Societal costs were estimated by collecting and analyzing labor costs, carer costs, sickness benefits, disability benefits, and home care benefits. Cost inputs were derived from publicly available databases or from the published literature. Expert opinion was only used if no other source was available. Efficacy data from two randomized clinical trials were used. The time horizon in the health economic model was lifetime. Efficacy and costs were discounted by 3.5%. All main model parameters were tested in deterministic and probabilistic sensitivity analyses. RESULTS: Mean incremental savings to society per patient ranged from €2277 in Italy to €4461 in Germany. The results were most sensitive to the change in proportion of patients working fulltime and the proportion of patients who were able to return to work. CONCLUSION: This analysis shows that bevacizumab-based treatment in non-small-cell lung cancer is associated with more savings to society compared to standard chemotherapy in terms of increased productivity and decreased social benefits paid to patients who are able to work in France, Germany, Italy, and Spain

Global citizenship as the completion of cosmopolitanism

A conception of global citizenship should not be viewed as separate from, or synonymous with, the cosmopolitan moral orientation, but as a primary component of it. Global citizenship is fundamentally concerned with individual moral requirements in the global frame. Such requirements, framed here as belonging to the category of individual cosmopolitanism, offer guidelines on right action in the context of global human community. They are complementary to the principles of moral cosmopolitanism – those to be used in assessing the justice of global institutions and practices – that have been emphasised by cosmopolitan political theorists. Considering principles of individual and moral cosmopolitanism together can help to provide greater clarity concerning individual duties in the absence of fully global institutions, as well as clarity on individual obligations of justice in relation to emerging and still-developing trans-state institutions

Hibernation in pygmy lorises (Nycticebus pygmaeus)–what does it mean?

Torpor use in primates appeared to be restricted to African species and was only recently discovered in a species from Asia, the pygmy loris (Nycticebus pygmaeus). This finding has considerable implications for our perception of torpor in this mammal group and demonstrates that torpor is probably more widespread in mammals than commonly thought. This article summarizes the current knowledge on the use of torpor in the pygmy loris and places it into the context of ongoing research on this topic