Poetry, painting and change on the edge of England

In this article we discuss our creative research on and with a contested coastal community on one of the UK's last existing plotlands, the humberston Fitties. Plotlands can be briefly defined as places where individuals have historically self‐built holiday houses. This 56‐acre strip of land with 319 chalets is on the Humber estuary and lies close to Cleethorpes, a seaside resort, and Grimsby, a seaport now facing post‐industrial decline. Our cross‐disciplinary collaborative practice between poetry and visual art explores open, environmentally aware engagements and methodologies with landscape and rural place. We investigate the relation of social, environmental and energy politics, looking out to land and sea and back to the community. Our results include original art and poetry presented innovatively together in exhibitions and books, in addition to local people's responses to our methodologies and the work itself

Statistical comparison of electron loss and enhancement in the outer radiation belt during storms

The near-relativistic electron population in the outer Van Allen radiation belt is highly dynamic and strongly coupled to geomagnetic activity such as storms and substorms, which are driven by the interaction of the magnetosphere with the solar wind. The energy, content and spatial extent of electrons in the outer radiation belt can vary on timescales of hours to days, dictated by the continuously evolving influence of acceleration and loss processes. While net changes in the electron population are directly observable, the relative influence of different processes is far from fully understood. Using a continuous 12-year dataset from the Proton Electron Telescope (PET) on board the Solar Anomalous Magnetospheric Particle Explorer (SAMPEX), we statistically compare the relative variations of trapped electrons to those in the bounce loss cone. Our results show that there is a proportional increase in flux entering the bounce loss cone outside the plasmapause during storm main phase and early recovery phase. Loss enhancement is sustained on the dawnside throughout the recovery phase while loss on the duskside is enhanced around minimum Sym-H and quickly diminishes. Spatial variations are also examined in relation to geomagnetic activity, making comparisons to possible causal wave modes such as whistler-mode chorus and plasmaspheric hiss

Exile Vol. XXXI No. 1

Drawing by Chris Bradley 1 How Goes the Wombat, Prithee by Jennie Benford 3 Holy Shit (for Mary) by Stephanie Athey 4-5 ..... blues by Britton R. Creelman 6 Photograph (anonymous) 7 Prose by Leigh Walton 9-12 San Jacinto by Petersen S. Thomas 13 Rebuttal by Betsy Oster 15 Running Alone by Ann Townsend McMullen 16 Windows in Florence by Michael Parr 17 Rangers by Caroline Palmer 19 Salamapo by Mary Deborah Clark 20-21 Funeral by J. K. Rand 22 Deeds Give No Title by Douglas Jones 23 Be Careful, There\u27s a Straight Bar Next Door by Karen J. Hall 25 The Rivers of Saigon by Alex Dickson 26 2 Sketches by Alfred Sturla Bodvarsson 27 Upon the Occasion of Reading 236 sonnets at One Sitting by Jeff Masten 28 I just believe in Me by Rob Jackson 29 Close by Stephanie Athey 31 Teller by Katherine Fox Reynolds 32 Woman in Greece by Michael Parr 33 Part of the Job by Joan DeWitt 35-44 Contributor Notes 46 Editorial decision is shared equally among the seven member editorial board. -title page Polymorphous: Cover Lithograph by Aimee Creelman - title pag

Spectral and Timing Analysis of NuSTAR and Swift/XRT Observations of the X-Ray Transient MAXI J0637-430

We present results for the first observed outburst from the transient X-ray binary source MAXI J0637-430. This study is based on eight observations from the Nuclear Spectroscopic Telescope Array (NuSTAR) and six observations from the Neil Gehrels Swift Observatory X-Ray Telescope (Swift/XRT) collected from 2019 November 19 to 2020 April 26 as the 3-79 keV source flux declined from 8.2 × 10-10 to 1.4 × 10-12 erg cm-2 s-1. We see the source transition from a soft state with a strong disk-blackbody component to a hard state dominated by a power-law or thermal Comptonization component. NuSTAR provides the first reported coverage of MAXI J0637-430 above 10 keV, and these broadband spectra show that a two-component model does not provide an adequate description of the soft-state spectrum. As such, we test whether blackbody emission from the plunging region could explain the excess emission. As an alternative, we test a reflection model that includes a physical Comptonization continuum. Finally, we also test a spectral component based on reflection of a blackbody illumination spectrum, which can be interpreted as a simple approximation to the reflection produced by returning disk radiation due to the bending of light by the strong gravity of the black hole. We discuss the physical implications of each scenario and demonstrate the value of constraining the source distance

Observations on the changing language of accounting

The meaning of words can change over time. In addition, new words may enter a language, sometimes replacing other words. This article extends prior literature on language change in accounting by drawing to a larger extent on theories from linguistics, and by placing greater emphasis on mechanisms of and motivations for change. Particular emphasis is placed on the need to verbalize new concepts, and sociocultural change. The latter is illustrated with examples from the development of accounting as an occupational interest group, and the adoption of Anglo-American accounting terminology and culture. The article concludes that language change in accounting, including transmission between languages and cultures, can inform accounting historians about the transfer of technical developments, as well as about socio-economic, political or ideological processes, power relationships, and the importance of terminology in jurisdictional disputes

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

The genetic architecture of the human cerebral cortex

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function

Subcortical volumes across the lifespan: data from 18,605 healthy individuals aged 3-90 years

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.Education and Child Studie