A qualitative study of satisfaction and dissatisfaction with Jobcentre Plus; an exploration of issues identified in the 2007 Customer Satisfaction Survey with a particular focus on those most likely to be dissatisfied

This report presents the findings of qualitative research undertaken with Jobcentre Plus staff and customers to further understand the findings of the 2007 Customer Satisfaction Survey. The research took place in all 11 regions/countries between September and December 2008 and involved interviews with staff from jobcentres and Benefit Delivery Centres, and follow-up telephone interviews and focus groups with customers. The report identifies differences in the drivers of satisfaction and dissatisfaction between different benefit groups. It also explores customer satisfaction with different services and contact channels, identifies what is seen as good customer service and puts forward some suggestions for how this may be improved

Engineering calculations for communications satellite systems planning

The final phase of a satellite synthesis project is described. Several methods for generating satellite positionings with improved aggregate carrier to interference characteristics were studied. Two general methods for modifying required separation values are presented. Also, two methods for improving aggregate carrier to interference (C/I) performance of given satellite synthesis solutions are presented. A perturbation of the World Administrative Radio Conference (WARC) synthesis is presented

Searching for the Donor Stars of ULX Pulsars

We report on our search for the optical counterparts of two ultraluminous X-ray pulsars with known orbital periods, M82 X-2 and NGC 5907 X-1, in new and archival HST observations, in an effort to characterize the donor stars in these systems. We detect five near-infrared sources consistent with the position of M82 X-2 that are too bright to be single stars. We also detect seven sources in the WFC3/UVIS F336W image whose photometry matches that of 10-15 M$_\odot$ stars turning off the main sequence. Such stars have densities consistent with the properties of the donor star of M82 X-2 as inferred from X-ray timing analysis, although it is also possible that the donor is a lower mass star below our detection limit or that there is a significant contribution from the accretion disc to the optical emission. We detect three candidate counterparts to NGC 5907 X-1 in the near-infrared. All of these are too bright to be the donor star of the ULX, which based on its orbital period is a red giant. The high background at the location of NGC 5907 X-1 precludes us from detecting this expected donor star. The recently discovered NGC 5907 ULX-2 also falls within the field of view of the near-infrared imaging; we detect four sources in the error circle, with photometry that matches AGB stars. The star suggested to be the counterpart of NGC 5907 ULX-2 by Pintore et al. (2018) falls outside our 2-$\sigma$ error circle.Comment: 10 pages, 3 figures, accepted for publication in Ap

Aircraft and satellite measurement of ocean wave directional spectra using scanning-beam microwave radars

A microwave radar technique for remotely measuring the vector wave number spectrum of the ocean surface is described. The technique, which employs short-pulse, noncoherent radars in a conical scan mode near vertical incidence, is shown to be suitable for both aircraft and satellite application, the technique was validated at 10 km aircraft altitude, where we have found excellent agreement between buoy and radar-inferred absolute wave height spectra

Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology

© 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins. Poor activity alleles of CYP2C19 are very frequent worldwide, particularly in Asia, raising the possibility that reduced metabolism could be advantageous in some circumstances. The evolutionary selective forces acting on this gene have not previously been investigated. We analyzed CYP2C19 genetic markers from 127 Gambians and on 120 chromosomes from Yoruba, Europeans and Asians (Japanese + Han Chinese) in the Hapmap database. Haplotype breakdown was explored using bifurcation plots and relative extended haplotype homozygosity (REHH). Allele frequency differentiation across populations was estimated using the fixation index (FST) and haplotype diversity with coalescent models. Results: Bifurcation plots suggested conservation of alleles conferring slow metabolism (CYP2C19∗2 and ∗3). REHH was high around CYP2C19∗2 in Yoruba (REHH 8.3, at 133.3 kb from the core) and to a lesser extent in Europeans (3.5, at 37.7 kb) and Asians (2.8, at -29.7 kb). FST at the CYP2C19 locus was low overall (0.098). CYP2C19∗3 was an FST outlier in Asians (0.293), CYP2C19 haplotype diversity ST is low at the CYP2C19 locus, suggesting balancing selection overall. The biological factors responsible for these selective pressures are currently unknown. One possible explanation is that early humans were exposed to a ubiquitous novel toxin activated by CYP2C19. The genetic adaptation took place within the last 10,000 years which coincides with the development of systematic agricultural practices.This work was supported by the Medical Research Council Unit The Gambia and the European and Developing Countries Clinical Trials Partnership [grant number CG_ta_05_40204_018]

Gated metabolic myocardial imaging, a surrogate for dual perfusion-metabolism imaging by positron emission tomography

Acknowledgments The authors are grateful for the help from Dr H Ali and Dr A Dawson. Funding: This study was performed using a research grant from the Aberdeen Royal Hospitals Trust's Endowment Fund, with further support from the Department of Medical Physics at the University of Aberdeen, for which the authors express their gratitude.Peer reviewedPublisher PD

The Fallaciousness of Threats: Character and Ad Baculum .

Robert Kimball, in “What’s Wrong with Argumentum Ad Baculum?” (Argumentation, 2006) argues that dialogue-based models of rational argumentation do not satisfactorily account for what is objectionable about more malicious uses of threats encountered in some ad baculum arguments. We review the dialogue-based approach to argumentum ad baculum, and show how it can offer more than Kimball thinks for analyzing such threat arguments and ad baculum fallacie