537 research outputs found

    “Am I not human?”: Reasserting humanness in response to group-based dehumanization

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    Research on group dehumanization has focused largely on the perpetrators of dehumanization or on its negative emotional and cognitive effects on targets. We theorized that people would also reassert their humanness in response to dehumanizing portrayals of their group. Experiment 1 showed that Black individuals responded to a dehumanizing representation of their racial group by emphasizing their experience of more complex, uniquely human emotions versus emotions more associated with other animals. Experiment 2 and a supplemental experiment showed that Black, but not White, individuals responded to group-based dehumanization by depicting more complex self-portrayals. Taken together, these studies begin to illustrate that targets of group-based dehumanization are not simply passive victims but respond actively, resisting negative representations of their group by reasserting their humanness

    TaxonomĂ­a del gĂŠnero Arachis (Leguminosae)

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    Almost 100 years elapsed between Linnaeus' naming the then lone species of Arachis (A. hypogaea L.), known to Europeans, and the first taxonomic treatment of the genus by Benthamin 1841. During the next 100 years five to ten additional species descriptions appeared,assigning different species to the same names,different names to the same species. By mid20th century, it was impossible to examine anyherbarium collection of Arachis and assign any epithet with any assurance to any specimen (which was not a type collection) except to A. hypogaea, A. guaranitica, A. tuberosa and A. villosulicarpa. In our treatment the Iiterature of this botanical chaos in Arachis is reviewed in detail and an assessment is made of the foundations for its occurrence. It is shown that the bases for the confusion lay in the combination of the esoteric nature of the differentiating morphological features of Arachis, the fragmentary early collections and the representation of species by seedling specimens. Also, it is related how, in 1959, we decided to re-explore the type locality of each species then known, collect therein complete plant specimens and thereby resolve the problem. Thirty five years, two generations of plant collectors and around 2000 collections later we present here 69 species descriptions of Arachis, species distributed in South America east of the Andes, south of the Amazon, north of La Plata and from NW Argentina to NE Brazil. We soon discovered that the most significant characters of Arachis lay in their underground structures, including their fruits, rhizomatous stems, root systems and hypocotyls. We showed that these defining characters tended to cluster the collections into groups which were associated with generally different geographic areas and ecological features. We drew a sample of 100 collections representing these c1usters, areas and features and arranged them in a hybridization diallel and showed, in crosses between collections representing different c1usters of characters, areas and features, a remarkable number of complete failures to cross-fertilize and in those hybrids which were recovered a high degree of F1 hybrid infertility. When these cross-incompatibilities and pollen infertilities were combined with the data on character-clustering, the nine distinct sections of the genus presented here then crystallized. Figures imposed upon maps of South America iIIustrate the geographic distributions of these sections. The collections were then assigned to the different sections on the bases of crossincompatibility and exo-morphologic character clustering. When these groups were made the esoteric characteristics, referred to aboye, so confounding when applied across sectionallines, became highly pertinent when applied to the problema of species differentiation between collections within sections. These, applied in conjunction with chromosome cytology, chromatographic and antigenic reactions, variations in intra-sectional hybrid fertility and adaptations of plant form and annual and perennial habit, allowed us to assemble the following taxa of the genus Arachis: Section 1. TR/ERECTO/DES nov.: 1. A. guaranitica, 2. A. tuberosa. Section 11. ERECTO/DES nov.: 3. A. Martií, 4. A. brevipetio/ata nov., 5. A. Oteroi nov., 6. A. Hatschbach;i nov., 7. A. cryptopotamica nov., 8. A. majar nov., 9. A. Benthamií, 10. A. douradiana nov., 11. A. gracilis nov., 12. A. Hermannií nov., 13. A. Archer; nov., 14. A. stenophylla nov., 15a. A. paraguariensis subsp. paraguariensis, 15b. A. paraguariensis subsp. capibarensis nov. Section 111. EXTRANERVOSAE nov.: 16. A. setinervosa nov., 17. A. Macedoi nov., 18. A. marginata, 19. A. prostrata, 20. A. lutescens, 21. A. retusa nov., 22. A. Burchellii nov., 23. A. Pietrarellii nov., 24. A. villosulicarpa. Section IV. TRISEMINATAE nov.: 25. A. triseminata nov.. Section V. HETERANTHAE nov.: 26. A. Giacomettii nov., 27. A. sylvestris, 28. A. pusilla, 29. A. Dardani nov. Section VI CAULORRHIZAE nov.: 30. A. repens, 31. A. Pintoi nov.. Section VII. PROCUMBENTES nov.: 32. A. lignosa nov. comb., 33. A. Kretschmeri nov., 34. A. Rigonii, 35. A. chiquitana nov., 36. A. matiensis nov., 37. A. appressipi/a nov., 38. A. Vallsii nov., 39. A. subcoriacea nov. Section VIII. RHIZOMATOSAEnov., Series. PRORHIZOMATOSAEnov.: 40. A. Burkartii. Series. RHIZOMATOSAE nov.: 41. A. pseudovillosa nov. comb., 42a. A. glabrata varo glabrata, 42b. A. glabrata varo Hagenbeckii. Section IX. ARACHIS: 43. A. glandulifera, 44. A. cruziana nov., 45. A. monticola, 46. A. magna nov., 47. A. ipaensis nov., 48. A. valida nov., 49. A. Williamsii nov., 50. A. Batizocoi, 51. A. duranensis nov., 52. A. Hoehnei nov., 53. A. stenosperma nov., 54. A. praecox nov., 55. A. palustris nov., 56. A. benensis nov., 57. A. trinitensis nov., 58. A. decora nov., 59. A. Herzogii nov., 60. A. microsperma nov., 61. A. vil/osa, 62. A. helodes, 63. A. correntina nov. comb., 64. A. Simpsonii nov., 65. A. Cardenasii nov., 66. A. Kempff-Mercadoi nov., 67. A. Diogoi, 68. A. Kuhlmannii nov., 69a. A hypogaea subsp. hypogaea varo 1. hypogaea, var.2. hirsuta, 69b. A. hypogaea subsp. fastigiata var.1. fastigiata, var.2. peruviana nov., var.3. aequatoriana nov., varA. vulgaris. .The autogamous reproductive systems, agametic reproduction, underground fruiting habit and the limited means of seed dispersal are shown to be logically tied to the drift in chromosomal organization which gives rise to noticeable increases in infertility in crosses between different collections of the same species, to a variably higher infertility in crosses between species within sections, to a near total infertility in crosses between species from different sections. The evolutionary and phylogenetic relationships between the different sections are discussed and are further shown in a sequence of diagrams illustrating ideas presented. It is evident that the genetic distances separating the sections are far from being of the same magnitude.The presumably older (Triseminatae, Trierectoides, Erectoides, Extranervosae, and Heteranthae sections, except for section Erectoides, are much more isolated from the remaining sections and each other than those taken to be of more recent origin (Procumbentes, Caulorrhizae, Rhizomatosae, and Arachis). Arachis section is by far the largest section, containing about 40% of the species described. Species of the section appearto be spreading to newterritory and to be invading areas occupied by species of other sections. They grow intermixed with populations of Extranervosae in the. upper Paraguay basin and occupy common ground with section Procumbentes in the Gran Pantanal. They have reached the shores of La Plata and the southeastern coast of Brazil and grow from Yala in NW Argentina to the Tocantins in NE Brazil. They contain the world-wide cultivar A. hypogaea. Essentially every published work on the botanical history and taxonomy of Arachis is presented in individual specimen references and in the general bibliography. The history of A. hypogaea from the early 16th century to more recent times along with the common names in several native American languages provide a perspective on the antiquity of this cultivar and the level of civilization required for its creation. Six appendices provide supporting data and matters of record. Diagnostic keys to the sections and to the species within each section select the more sharply distinguishing guidesto the sections and species. Nineteen line drawings capture the sectional and species structures of whole plants, root systems, fruit orientations, agametic reproductions from fruiting structures, carpel shapes and surface features of leaves and stems

    Viral DNAemia and DNA virus seropositivity and mortality in pediatric sepsis

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    IMPORTANCE: Sepsis is a leading cause of pediatric mortality. Little attention has been paid to the association between viral DNA and mortality in children and adolescents with sepsis. OBJECTIVE: To assess the association of the presence of viral DNA with sepsis-related mortality in a large multicenter study. DESIGN, SETTING, AND PARTICIPANTS: This cohort study compares pediatric patients with and without plasma cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 (HSV-1), human herpesvirus 6 (HHV-6), parvovirus B19 (B19V), BK polyomavirus (BKPyV), human adenovirus (HAdV), and torque teno virus (TTV) DNAemia detected by quantitative real-time polymerase chain reaction or plasma IgG antibodies to CMV, EBV, HSV-1, or HHV-6. A total of 401 patients younger than 18 years with severe sepsis were enrolled from 9 pediatric intensive care units (PICUs) in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Data were collected from 2015 to 2018. Samples were assayed from 2019 to 2022. Data were analyzed from 2022 to 2023. MAIN OUTCOMES AND MEASURES: Death while in the PICU. RESULTS: Among the 401 patients included in the analysis, the median age was 6 (IQR, 1-12) years, and 222 (55.4%) were male. One hundred fifty-four patients (38.4%) were previously healthy, 108 (26.9%) were immunocompromised, and 225 (56.1%) had documented infection(s) at enrollment. Forty-four patients (11.0%) died in the PICU. Viral DNAemia with at least 1 virus (excluding TTV) was detected in 191 patients (47.6%) overall, 63 of 108 patients (58.3%) who were immunocompromised, and 128 of 293 (43.7%) who were not immunocompromised at sepsis onset. After adjustment for age, Pediatric Risk of Mortality score, previously healthy status, and immunocompromised status at sepsis onset, CMV (adjusted odds ratio [AOR], 3.01 [95% CI, 1.36-6.45]; P = .007), HAdV (AOR, 3.50 [95% CI, 1.46-8.09]; P = .006), BKPyV (AOR. 3.02 [95% CI, 1.17-7.34]; P = .02), and HHV-6 (AOR, 2.62 [95% CI, 1.31-5.20]; P = .007) DNAemia were each associated with increased mortality. Two or more viruses were detected in 78 patients (19.5%), with mortality among 12 of 32 (37.5%) who were immunocompromised and 9 of 46 (19.6%) who were not immunocompromised at sepsis onset. Herpesvirus seropositivity was common (HSV-1, 82 of 246 [33.3%]; CMV, 107 of 254 [42.1%]; EBV, 152 of 251 [60.6%]; HHV-6, 253 if 257 [98.4%]). After additional adjustment for receipt of blood products in the PICU, EBV seropositivity was associated with increased mortality (AOR, 6.10 [95% CI, 1.00-118.61]; P = .049). CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that DNAemia for CMV, HAdV, BKPyV, and HHV-6 and EBV seropositivity were independently associated with increased sepsis mortality. Further investigation of the underlying biology of these viral DNA infections in children with sepsis is warranted to determine whether they only reflect mortality risk or contribute to mortality

    Stereotype Threat in Organizations: Implications for Equity and Performance

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    Abstract Over the past 20 years, a large body of laboratory and field research has shown that, when people perform in settings in which their group is negatively stereotyped, they may experience a phenomenon called stereotype threat that can undermine motivation and trust and cause underperformance. This review describes that research and places it into an organizational context. First, we describe the processes by which stereotype threat can impair outcomes among people in the workplace. Next, we delineate the situational cues in organizational settings that can exacerbate stereotype threat, and explain how and why these cues affect stereotyped individuals. Finally, we discuss relatively simple empirically based strategies that organizations can implement to reduce stereotype threat and create conditions in which employees and applicants from all groups can succeed

    Reassessing the association: Evaluation of a polyalanine deletion variant of RUNX2 in non‐syndromic sagittal and metopic craniosynostosis

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    The RUNT‐related transcription factor RUNX2 plays a critical role in osteoblast differentiation, and alterations to gene dosage cause distinct craniofacial anomalies. Uniquely amongst the RUNT‐related family, vertebrate RUNX2 encodes a polyglutamine/polyalanine repeat (Gln23‐Glu‐Ala17 in humans), with the length of the polyalanine component completely conserved in great apes. Surprisingly, a frequent 6‐amino acid deletion polymorphism, p.(Ala84_Ala89)del, occurs in humans (termed 11A allele), and a previous association study (Cuellar et al. Bone 137:115395;2020) reported that the 11A variant was significantly more frequent in non‐syndromic sagittal craniosynostosis (nsSag; allele frequency [AF] = 0.156; 95% confidence interval [CI] 0.126–0.189) compared to non‐syndromic metopic craniosynostosis (nsMet; AF = 0.068; 95% CI 0.045–0.098). However, the gnomAD v.2.1.1 control population used by Cuellar et al. did not display Hardy–Weinberg equilibrium, hampering interpretation. To re‐examine this association, we genotyped the RUNX2 11A polymorphism in 225 individuals with sporadic nsSag as parent–child trios and 164 singletons with sporadic nsMet, restricting our analysis to individuals of European ancestry. We compared observed allele frequencies to the non‐transmitted alleles in the parent–child trios, and to the genome sequencing data from gnomAD v.4, which display Hardy–Weinberg equilibrium. Observed AFs (and 95% CI) were 0.076 (0.053–0.104) in nsSag and 0.082 (0.055–0.118) in nsMet, compared with 0.062 (0.042–0.089) in non‐transmitted parental alleles and 0.065 (0.063–0.067) in gnomAD v.4.0.0 non‐Finnish European control genomes. In summary, we observed a non‐significant excess, compared to gnomAD data, of 11A alleles in both nsSag (relative risk 1.18, 95% CI 0.83–1.67) and nsMet (relative risk 1.29, 95% CI 0.87–1.92), but we did not replicate the much higher excess of RUNX2 11A alleles in nsSag previously reported (p = 0.0001)

    Silly Questions and Arguments for the Implicit, Cinematic Narrator

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    My chapter aims to advance the debate on a problem often raised by philosophers who are skeptical of implied narrators in movies. This is the concern that positing such elusive narrators gives rise to absurd imaginings (Gaut 2004: 242; Carroll 2006: 179-180). Friends of the implied cinematic narrator reply that the questions critics raise about the workings of the implied cinematic narrator are "silly ones" to ask. I examine how the "absurd imaginings" problem arises for all the central arguments for the elusive cinematic narrator and discuss why the questions critics pose about this narrator are legitimate ones to ask

    Activity, stability and 3-D structure of the Cu(II) form of a chitin-active lytic polysaccharide monooxygenase from Bacillus amyloliquefaciens

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    The enzymatic deconstruction of recalcitrant polysaccharide biomass is central to the conversion of these substrates for societal benefit, such as in biofuels. Traditional models for enzyme-catalysed polysaccharide degradation involved the synergistic action of endo-, exo-and processive glycoside hydrolases working in concert to hydrolyse the substrate. More recently this model has been succeeded by one featuring a newly discovered class of mononuclear copper enzymes: lytic polysaccharide monooxygenases (LPMOs; classified as Auxiliary Activity (AA) enzymes in the CAZy classification). In 2013, the structure of an LPMO from Bacillus amyloliquefaciens, BaAA10, was solved with the Cu centre photoreduced to Cu(I) in the X-ray beam. Here we present the catalytic activity of BaAA10. We show that it is a chitin-active LPMO, active on both ι and β chitin, with the Cu(II) binding with low nM KD, and the substrate greatly increasing the thermal stability of the enzyme. A spiral data collection strategy has been used to facilitate access to the previously unobservable Cu(II) state of the active centre, revealing a coordination geometry around the copper which is distorted from axial symmetry, consistent with the previous findings from EPR spectroscopy

    Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

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    Elevated total cholesterol in midlife has been associated with increased risk of dementia in later life. We have previously shown that low-density lipoprotein (LDL) is more oxidized in the plasma of dementia patients, although total cholesterol levels are not different from those of age-matched controls. β-Amyloid (Aβ) peptide, which accumulates in Alzheimer disease (AD), arises from the initial cleavage of amyloid precursor protein by β-secretase-1 (BACE1). BACE1 activity is regulated by membrane lipids and raft formation. Given the evidence for altered lipid metabolism in AD, we have investigated a mechanism for enhanced Aβ production by SH-SY5Y neuronal-like cells exposed to oxidized LDL (oxLDL). The viability of SH-SY5Y cells exposed to 4 Οg oxLDL and 25 ΟM 27-hydroxycholesterol (27OH-C) was decreased significantly. Lipids, but not proteins, extracted from oxLDL were more cytotoxic than oxLDL. In parallel, the ratio of reduced glutathione (GSH) to oxidized glutathione was decreased at sublethal concentrations of lipids extracted from native and oxLDL. GSH loss was associated with an increase in acid sphingomyelinase (ASMase) activity and lipid raft formation, which could be inhibited by the ASMase inhibitor desipramine. 27OH-C and total lipids from LDL and oxLDL independently increased Aβ production by SH-SY5Y cells, and Aβ accumulation could be inhibited by desipramine and by N-acetylcysteine. These data suggest a mechanism whereby oxLDL lipids and 27OH-C can drive Aβ production by GSH depletion, ASMase-driven membrane remodeling, and BACE1 activation in neuronal cells. Š 2014 The Authors
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