The potential of cannabidiol in the COVID‐19 pandemic.

Identifying candidate drugs effective in the new coronavirus disease 2019 (Covid-19) is crucial, pending a vaccine against SARS-CoV2. We suggest the hypothesis that Cannabidiol (CBD), a non-psychotropic phytocannabinoid, has the potential to limit the severity and progression of the disease for several reasons: 1) High-CBD Cannabis Sativa extracts are able to downregulate the expression of the two key receptors for SARS-CoV2 in several models of human epithelia 2) CBD exerts a wide range of immunomodulatory and anti-inflammatory effects and it can mitigate the uncontrolled cytokine production featuring Acute Lung Injury 3) Being a PPARγ agonist, it can display a direct antiviral activity 4) PPARγ agonists are regulators of fibroblast/myofibroblast activation and can inhibit the development of pulmonary fibrosis, thus ameliorating lung function in recovered patients. We hope our hypothesis, corroborated by several preclinical evidence, will inspire further targeted studies to test CBD as a support drug against the COVID-19 pandemic

Autonomous Robotic Screening of Tubular Structures based only on Real-Time Ultrasound Imaging Feedback

Ultrasound (US) imaging is widely employed for diagnosis and staging of peripheral vascular diseases (PVD), mainly due to its high availability and the fact it does not emit radiation. However, high inter-operator variability and a lack of repeatability of US image acquisition hinder the implementation of extensive screening programs. To address this challenge, we propose an end-to-end workflow for automatic robotic US screening of tubular structures using only the real-time US imaging feedback. We first train a U-Net for real-time segmentation of the vascular structure from cross-sectional US images. Then, we represent the detected vascular structure as a 3D point cloud and use it to estimate the longitudinal axis of the target tubular structure and its mean radius by solving a constrained non-linear optimization problem. Iterating the previous processes, the US probe is automatically aligned to the orientation normal to the target tubular tissue and adjusted online to center the tracked tissue based on the spatial calibration. The real-time segmentation result is evaluated both on a phantom and in-vivo on brachial arteries of volunteers. In addition, the whole process is validated both in simulation and physical phantoms. The mean absolute radius error and orientation error ($\pm$ SD) in the simulation are $1.16\pm0.1~mm$ and $2.7\pm3.3^{\circ}$, respectively. On a gel phantom, these errors are $1.95\pm2.02~mm$ and $3.3\pm2.4^{\circ}$. This shows that the method is able to automatically screen tubular tissues with an optimal probe orientation (i.e. normal to the vessel) and at the same to accurately estimate the mean radius, both in real-time.Comment: Accepted for publication in IEEE Transactions on Industrial Electronics Video: https://www.youtube.com/watch?v=VAaNZL0I5i

Stringent neutron-star limits on large extra dimensions

Supernovae (SNe) are copious sources for Kaluza-Klein gravitons which are generic for theories with large extra dimensions. These massive particles are produced with average velocities ~0.5 c so that many of them are gravitationally retained by the SN core. Every neutron star thus has a halo of KK gravitons which decay into nu bar-nu, e^+e^- and gamma gamma on time scales \~10^9 years. The EGRET gamma-flux limits (E_gamma ~ 100 MeV) for nearby neutron stars constrain the fundamental scale for n=2 extra dimensions to M >500 TeV, and M>30 TeV for n=3. The upcoming GLAST satellite is a factor ~30 more sensitive and thus may detect KK decays, for example at the nearby neutron star RX J185635--3754. The requirement that neutron stars are not excessively heated by KK decays implies M>1700 TeV for n=2, and M>60 TeV for n=3.Comment: Minor changes, matches version to appear in PR

Skyrmion fluctuations at a first-order phase transition boundary

Magnetic skyrmions are topologically protected spin textures with promising prospects for applications in data storage. They can form a lattice state due to competing magnetic interactions and are commonly found in a small region of the temperature - magnetic field phase diagram. Recent work has demonstrated that these magnetic quasi-particles fluctuate at the μeV energy scale. Here, we use a coherent x-ray correlation method at an x-ray free-electron laser to investigate these fluctuations in a magnetic phase coexistence region near a first-order transition boundary where fluctuations are not expected to play a major role. Surprisingly, we find that the relaxation of the intermediate scattering function at this transition differs significantly compared to that deep in the skyrmion lattice phase. The observation of a compressed exponential behavior suggests solid-like dynamics, often associated with jamming. We assign this behavior to disorder and the phase coexistence observed in a narrow field-window near the transition, which can cause fluctuations that lead to glassy behavior

A palmitoylethanolamide producing lactobacillus paracasei improves clostridium difficile toxin a-induced colitis

Genetically engineered probiotics, able to in situ deliver therapeutically active compounds while restoring gut eubiosis, could represent an attractive therapeutic alternative in Clostridium difficile infection (CDI). Palmitoylethanolamide is an endogenous lipid able to exert immunomodulatory activities and restore epithelial barrier integrity in human models of colitis, by binding the peroxisome proliferator–activated receptor-α (PPARα). The aim of this study was to explore the efficacy of a newly designed PEA-producing probiotic (pNAPE-LP) in a mice model of C. difficile toxin A (TcdA)-induced colitis. The human N-acyl-phosphatidylethanolamine-specific phospholipase D (NAPE-PLD), a key enzyme involved in the synthesis of PEA, was cloned and expressed in a Lactobacillus paracasei that was intragastrically administered to mice 7 days prior the induction of the colitis. Bacteria carrying the empty vector served as negative controls (pLP).In the presence of palmitate, pNAPE-LP was able to significantly increase PEA production by 27,900%, in a time- and concentration-dependent fashion. Mice treated with pNAPE-LP showed a significant improvement of colitis in terms of histological damage score, macrophage count, and myeloperoxidase levels (−53, −82, and −70.4%, respectively). This was paralleled by a significant decrease both in the expression of toll-like receptor-4 (−71%), phospho-p38 mitogen-activated protein kinase (−72%), hypoxia-inducible factor-1-alpha (−53%), p50 (−74%), and p65 (−60%) and in the plasmatic levels of interleukin-6 (−86%), nitric oxide (−59%), and vascular endothelial growth factor (−71%). Finally, tight junction protein expression was significantly improved by pNAPE-LP treatment as witnessed by the rescue of zonula occludens-1 (+304%), Ras homolog family member A-GTP (+649%), and occludin expression (+160%). These protective effects were mediated by the specific release of PEA by the engineered probiotic as they were abolished in PPARα knockout mice and in wild-type mice treated with pLP. Herein, we demonstrated that pNAPE-LP has therapeutic potential in CDI by inhibiting colonic inflammation and restoring tight junction protein expression in mice, paving the way to next generation probiotics as a promising strategy in CDI prevention

Two years of monitoring Supergiant Fast X-ray Transients with Swift

We present two years of intense Swift monitoring of three SFXTs, IGR J16479-4514, XTE J1739-302, and IGR J17544-2619 (since October 2007). Out-of-outburst intensity-based X-ray (0.3-10keV) spectroscopy yields absorbed power laws with by hard photon indices (G~1-2). Their outburst broad-band (0.3-150 keV) spectra can be fit well with models typically used to describe the X-ray emission from accreting NSs in HMXBs. We assess how long each source spends in each state using a systematic monitoring with a sensitive instrument. These sources spend 3-5% of the total in bright outbursts. The most probable flux is 1-2E-11 erg cm^{-2} s^{-1} (2-10 keV, unabsorbed), corresponding to luminosities in the order of a few 10^{33} to 10^{34} erg s^{-1} (two orders of magnitude lower than the bright outbursts). The duty-cycle of inactivity is 19, 39, 55%, for IGR J16479-4514, XTE J1739-302, and IGR J17544-2619, respectively. We present a complete list of BAT on-board detections further confirming the continued activity of these sources. This demonstrates that true quiescence is a rare state, and that these transients accrete matter throughout their life at different rates. X-ray variability is observed at all timescales and intensities we can probe. Superimposed on the day-to-day variability is intra-day flaring which involves variations up to one order of magnitude that can occur down to timescales as short as ~1ks, and whichcan be explained by the accretion of single clumps composing the donor wind with masses M_cl~0.3-2x10^{19} g. (Abridged)Comment: Accepted for publication in MNRAS. 17 pages, 11 figures, 8 table

Insight Into Campi Flegrei Caldera Unrest Through Seismic Tremor Measurements at Pisciarelli Fumarolic Field

Within a general volcanic unrest in the densely urbanized area of Campi Flegrei caldera (Italy) an increase in the activity of Pisciarelli hydrothermal area is occurring. The seismic amplitude of Pisciarelli fumarolic tremor is a proxy for the fluid emission rate of the entire Solfatara‐Pisciarelli hydrothermal system. The long‐term analysis indicates a significant increase, by a factor of ~3 of the fumarolic tremor amplitude since May 2017. This increment matches with the trend of geochemical and seismic parameters observed in Campi Flegrei, therefore highlighting that Pisciarelli is a key site to monitor the volcanic unrest underway in this high‐risk caldera. The analysis of data from three closely spaced seismic stations provided new clues about the source mechanism of the tremor. Analyzing the fumarolic tremor amplitude we could also identify an episode of enlargement of the emission area close to the main fumarole of Pisciarelli. We propose a monitoring system based on the fumarolic tremor analysis, which provides real‐time information on the Pisciarelli hydrothermal activity and therefore on the current unrest in Campi Flegrei caldera.Published5544-55554V. Processi pre-eruttiviJCR Journa

Titan airglow spectra from Cassini Ultraviolet Imaging Spectrograph (UVIS): EUV analysis

peer reviewedaudience: researcher, professional, studentWe present the first UV airglow observations of Titan's atmosphere by the Ultraviolet Imaging Spectrograph (UVIS) on Cassini. Using one spectral channel in the EUV from 561-1182 Å and one in the FUV from 1115-1913 Å, UVIS observed the disk on 13 December, 2004 at low solar activity. The EUV spectrum consists of three band systems of N[SUB]2[/SUB] (b [SUP]1[/SUP]∏[SUB]u[/SUB], b' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP], c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]), while the FUV spectrum consists of one (a [SUP]1[/SUP]∏[SUB]g[/SUB] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]). Both the EUV and FUV spectra contain many N I and N II multiplets that are produced primarily by photodissociative ionization. Spectral intensities of the N[SUB]2[/SUB] c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](v' = 0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP](v'' = 0-2) progression from 950-1010 Å are resolved for the first time. The UVIS observations reveal that the c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP] (0) vibrational band near 958 Å is weak and undetectable, and that N I multiplets near 953.2 and 964.5 Å are present instead. Magnetospheric particle excitation may be weak or sporadic, since the nightside EUV spectrum on this orbit shows no observable nitrogen emission features and only H Ly-β

Vulnerability in adolescence: a case report of attempted abortion and sexual violence

Background: Abortion, even when provided by law in cases of sexual violence, continues to be practiced in an insecure way, since women who suffer violence are not reported or guarded by social, institutional or age vulnerability, as in adolescence. Objective: Describe the clinical consequences of unsafe abortion, report this experience as well as sexual violence in situations of social and age vulnerability. Methods: It is a clinical case report, with the consent of the patient, in the year 2016, of a 16-year-old female adolescent with a personal history of sexual violence by an intimate aggressor. Admitted to the health service with diagnosis of acute abdomen and induced abortion using antibiotic therapy. Results: Laboratory tests revealed altered C reactive protein and presence of leukocytosis, ultrasound showed heterogenic mass, computed tomography showed presence of cylindrical foreign body in vaginal cavity, surgical interventions, sepsis, clinical complications (pulmonary thromboembolism) and prolonged hospitalization. Conclusion: The history of violence portrayed in this study reveals an attempt of abortion with self harm, revealing negative clinical repercussions and the health problems of the adolescent. This person has committed an abortion that does not fit into the abortion criteria provided by law. It also revealed the need for further discussion on the topic, highlighting health promotion practices against unsafe abortion