120 research outputs found
Statistical Origin of Quantum Mechanics
The one particle quantum mechanics is considered in the frame of a N-body
classical kinetics in the phase space. Within this framework, the scenario of a
subquantum structure for the quantum particle, emerges naturally, providing an
ontological support to the orthodox quantum mechanics. This approach to quantum
mechanics, constitutes a deductive and direct method which, in a
self-consistent scheme of a classical kinetics, allows us: i) to obtain the
probabilistic nature of the quantum description and to interpret the wave
function according to the Copenhagen school; ii) to derive the quantum
potential and then the Schr\"odinger equation; iii) to calculate the values of
the physical observables as mean values of the associated quantum operators;
iv) to obtain the Heisenberg uncertainty principle.Comment: Accepted for publication in Physica
A classical explanation of quantization
In the context of our recently developed emergent quantum mechanics, and, in
particular, based on an assumed sub-quantum thermodynamics, the necessity of
energy quantization as originally postulated by Max Planck is explained by
means of purely classical physics. Moreover, under the same premises, also the
energy spectrum of the quantum mechanical harmonic oscillator is derived.
Essentially, Planck's constant h is shown to be indicative of a particle's
"zitterbewegung" and thus of a fundamental angular momentum. The latter is
identified with quantum mechanical spin, a residue of which is thus present
even in the non-relativistic Schroedinger theory.Comment: 20 pages; version accepted for publication in Foundations of Physic
Einstein, incompleteness, and the epistemic view of quantum states
Does the quantum state represent reality or our knowledge of reality? In
making this distinction precise, we are led to a novel classification of hidden
variable models of quantum theory. Indeed, representatives of each class can be
found among existing constructions for two-dimensional Hilbert spaces. Our
approach also provides a fruitful new perspective on arguments for the
nonlocality and incompleteness of quantum theory. Specifically, we show that
for models wherein the quantum state has the status of something real, the
failure of locality can be established through an argument considerably more
straightforward than Bell's theorem. The historical significance of this result
becomes evident when one recognizes that the same reasoning is present in
Einstein's preferred argument for incompleteness, which dates back to 1935.
This fact suggests that Einstein was seeking not just any completion of quantum
theory, but one wherein quantum states are solely representative of our
knowledge. Our hypothesis is supported by an analysis of Einstein's attempts to
clarify his views on quantum theory and the circumstance of his otherwise
puzzling abandonment of an even simpler argument for incompleteness from 1927.Comment: 18 pages, 8 figures, 1 recipe for cupcakes; comments welcom
Thermodynamic Gravity and the Schrodinger Equation
We adopt a 'thermodynamical' formulation of Mach's principle that the rest
mass of a particle in the Universe is a measure of its long-range collective
interactions with all other particles inside the horizon. We consider all
particles in the Universe as a 'gravitationally entangled' statistical ensemble
and apply the approach of classical statistical mechanics to it. It is shown
that both the Schrodinger equation and the Planck constant can be derived
within this Machian model of the universe. The appearance of probabilities,
complex wave functions, and quantization conditions is related to the
discreetness and finiteness of the Machian ensemble.Comment: Minor corrections, the version accepted by Int. J. Theor. Phy
Ventricular volume expansion in presymptomatic genetic frontotemporal dementia
Objective: To characterize the time course of ventricular volume expansion in genetic frontotemporal dementia (FTD) and identify the onset time and rates of ventricular expansion in presymptomatic FTD mutation carriers.
Methods: Participants included patients with a mutation in MAPT, PGRN, or C9orf72, or first-degree relatives of mutation carriers from the GENFI study with MRI scans at study baseline and at 1 year follow-up. Ventricular volumes were obtained from MRI scans using FreeSurfer, with manual editing of segmentation and comparison to fully automated segmentation to establish reliability. Linear mixed models were used to identify differences in ventricular volume and in expansion rates as a function of time to expected disease onset between presymptomatic carriers and noncarriers.
Results: A total of 123 participants met the inclusion criteria and were included in the analysis (18 symptomatic carriers, 46 presymptomatic mutation carriers, and 56 noncarriers). Ventricular volume differences were observed 4 years prior to symptom disease onset for presymptomatic carriers compared to noncarriers. Annualized rates of ventricular volume expansion were greater in presymptomatic carriers relative to noncarriers. Importantly, time-intensive manually edited and fully automated ventricular volume resulted in similar findings.
Conclusions: Ventricular volume differences are detectable in presymptomatic genetic FTD. Concordance of results from time-intensive manual editing and fully automatic segmentation approaches support its value as a measure of disease onset and progression in future studies in both presymptomatic and symptomatic genetic FTD
Ventricular volume expansion in presymptomatic genetic frontotemporal dementia
OBJECTIVE: To characterize the time course of ventricular volume expansion in genetic frontotemporal dementia (FTD) and identify the onset time and rates of ventricular expansion in presymptomatic FTD mutation carriers. METHODS: Participants included patients with a mutation in MAPT, PGRN, or C9orf72, or first-degree relatives of mutation carriers from the GENFI study with MRI scans at study baseline and at 1 year follow-up. Ventricular volumes were obtained from MRI scans using FreeSurfer, with manual editing of segmentation and comparison to fully automated segmentation to establish reliability. Linear mixed models were used to identify differences in ventricular volume and in expansion rates as a function of time to expected disease onset between presymptomatic carriers and noncarriers. RESULTS: A total of 123 participants met the inclusion criteria and were included in the analysis (18 symptomatic carriers, 46 presymptomatic mutation carriers, and 56 noncarriers). Ventricular volume differences were observed 4 years prior to symptom disease onset for presymptomatic carriers compared to noncarriers. Annualized rates of ventricular volume expansion were greater in presymptomatic carriers relative to noncarriers. Importantly, time-intensive manually edited and fully automated ventricular volume resulted in similar findings. CONCLUSIONS: Ventricular volume differences are detectable in presymptomatic genetic FTD. Concordance of results from time-intensive manual editing and fully automatic segmentation approaches support its value as a measure of disease onset and progression in future studies in both presymptomatic and symptomatic genetic FTD
Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.
Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for the recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation
Comparison of Statistical Algorithms for the Detection of Infectious Disease Outbreaks in Large Multiple Surveillance Systems
A large-scale multiple surveillance system for infectious disease outbreaks has been in operation in England and Wales since the early 1990s. Changes to the statistical algorithm at the heart of the system were proposed and the purpose of this paper is to compare two new algorithms with the original algorithm. Test data to evaluate performance are created from weekly counts of the number of cases of each of more than 2000 diseases over a twenty-year period. The time series of each disease is separated into one series giving the baseline (background) disease incidence and a second series giving disease outbreaks. One series is shifted forward by twelve months and the two are then recombined, giving a realistic series in which it is known where outbreaks have been added. The metrics used to evaluate performance include a scoring rule that appropriately balances sensitivity against specificity and is sensitive to variation in probabilities near 1. In the context of disease surveillance, a scoring rule can be adapted to reflect the size of outbreaks and this was done. Results indicate that the two new algorithms are comparable to each other and better than the algorithm they were designed to replace
Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition
BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error. METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: 30 kg/m²], waist circumference (WC), hip circumference (HC) and waist to hip ratio (WHR) using Cox proportional hazards models. RESULTS: Among men, a BMI < 22.5 kg/m² was associated with higher HNC risk [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.23 - 2.12)]; BMI was not associated with HNC among women. WC and WHR were associated with greater risk of HNC among women, (WC per 5 cm: HR 1.08, 95% CI 1.02 - 1.15; WHR per 0.1 unit: HR 1.64, 95% CI 1.38 - 1.93). After stratification by smoking status, the association for WHR was present only among smokers (p interaction 0.004). Among men, WC and WHR were associated with HNC only upon additional adjustment for BMI (WC per 5 cm: HR 1.16, 95% CI 1.07 - 1.26; WHR per 0.1 unit: HR 1.42, 95% CI 1.21 - 1.65). CONCLUSION: Central adiposity, particularly among women, may have a stronger association with HNC risk than previously estimated. IMPACT: Strategies to reduce obesity may beneficially impact HNC incidence.The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); ERC- 2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), PI13/00061 to Granada; , PI13/01162 to EPIC-Murcia), Regional Governments of AndalucÃa, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of SkÃ¥ne and Västerbotten (Sweden); Cancer Research UK (14136 to K.T. Khaw, N.J. Wareham; C570/A16491 to R.C. Travis and C8221/A19170 to Tim Key (EPIC-Oxford), Medical Research Council (1000143 to K.T. Khaw, N.J. Wareham, MR/M012190/1 to Tim Key (EPIC-Oxford)) (United Kingdom)
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