Thematic catalogue of research topics on Swiss parks

With the implementation of the new parks legislation, Switzerland has experienced a boom in the establishment of parks of national importance. From a scientific point of view, this presents a unique opportunity to accompany these new parks and to establish long-term evaluation in order to assess the changes in and the impact of these areas. From a management point of view, parks depend on scientific results in order to take adequate measures for valorization and development of their areas. It is important to foster the dialogue between science and practice and to develop research topics, which can be analysed comparatively across several parks. Commissioned by the Federal Office of the Environment (FOEN), the coordination office Research on parks and its accompanying group of experts drew up a thematic catalogue of comparative research topics on parks and protected areas. This catalogue represents a first step towards formulating a research strategy and establishing a long-term impact assessment

Swiss Parks of National Importance as model regions of sustainable development – An economic success story for farmers?

Evidence on the socioeconomic effects of the protected area status of affected regions is mixed. While some studies highlight positive outcomes for these regions, others point in the opposite direction. Consequently, this study aimed to add to the discourse on whether protected area status fosters the socioeconomic development of these regions or not. The study focuses on the agricultural sector in protected areas, because this sector is of particular importance for local communes in these regions. Our study aimed to investigate whether the status Swiss Park of National Importance (henceforth park) positively or negatively influenced economic indicators of local farms (i.e., direct payments, income, and revenues). Specifically, the study answers the following question: How would economic farm indicators have developed if the territory had not gained park status? Thus, the study compared the economic indicators of farms located in a park with economic indicators of farms from neighboring regions outside the park. The analyses focused on the United Nations Educational, Scientific, and Cultural Organization (UNESCO) Biosphere Reserve Entlebuch and the Nature Park Gantrisch as case study regions. The empirical findings revealed that gaining the park status had neither positive nor negative significant effects on income of farms inside a park compared to similar farms outside. However, results also showed that gaining the park status had positive rather than negative effects on further economic indicators such as direct payments and revenues

A holistic assessment of the impacts of park management: findings from the evaluation of Regional Nature Parks in Switzerland

In Switzerland, Regional Nature Parks are required to undergo an impact assessment after ten years of operation, in order for the federal government to award the Park of National Importance label for a further ten years and for the government, relevant canton and communes to continue to provide financial support for the park’s operation. To this end, is there a convenient way of identifying and holistically assessing the impacts of park management activities on the goals of the parks and the overarching targets of parks policy in Switzerland? Based on experience gained from the evaluation of three Regional Nature Parks, we have developed a framework model for the holistic evaluation of such parks and present it here for discussion

Buried, forgotten and rediscovered - prospecting the Roman villae rusticae in the area of Flachgau in Salzburg, Austria

At six different villae rusticae sites in the Salzburger Flachgau high resolution motorized and non motorized magnetic and radar data was gained. The sites are well preserved due to sustainable agricultural use

Gesamtheitliche Evaluation der Wirkungen von Parkmanagements: Erkenntnisse aus der Evaluation von Regionalen Naturpärken in der Schweiz

In der Schweiz müssen sich die Regionalen Naturpärke nach zehn Jahren Betrieb einer Wirkungsanalyse unterziehen, damit der Bund das Label «Park von nationaler Bedeutung» für weitere zehn Jahre verleiht und der Bund, der Kanton und die Gemeinden den Betrieb des jeweiligen Naturparks weiterhin finanziell unterstützen. Gibt es zu diesem Zweck eine geeignete Vorgehensweise, um die Wirkungen des Parkmanagements auf die Ziele der Naturpärke und die übergeordneten Ziele der Pärkepolitik in der Schweiz zu identifizieren? – Basierend auf den Erfahrungen mit der Evaluation von drei Regionalen Naturpärken im Kanton Bern haben wir ein Rahmenmodell für die gesamtheitliche Evaluation solcher Pärke entwickelt und stellen es hier zur Diskussion

The ARCA Registry: A Collaborative Global Platform for Advancing Trial Readiness in Autosomal Recessive Cerebellar Ataxias.

Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of targeted therapies for ARCAs, disease registries have become a precious source of real-world quantitative and qualitative data complementing knowledge from preclinical studies and clinical trials. Here, we review the ARCA Registry, a global collaborative multicenter platform (>15 countries, >30 sites) with the overarching goal to advance trial readiness in ARCAs. It presents a good clinical practice (GCP)- and general data protection regulation (GDPR)-compliant professional-reported registry for multicenter web-based capture of cross-center standardized longitudinal data. Modular electronic case report forms (eCRFs) with core, extended, and optional datasets allow data capture tailored to the participating site's variable interests and resources. The eCRFs cover all key data elements required by regulatory authorities [European Medicines Agency (EMA)] and the European Rare Disease (ERD) platform. They capture genotype, phenotype, and progression and include demographic data, biomarkers, comorbidity, medication, magnetic resonance imaging (MRI), and longitudinal clinician- or patient-reported ratings of ataxia severity, non-ataxia features, disease stage, activities of daily living, and (mental) health status. Moreover, they are aligned to major autosomal-dominant spinocerebellar ataxia (SCA) and sporadic ataxia (SPORTAX) registries in the field, thus allowing for joint and comparative analyses not only across ARCAs but also with SCAs and sporadic ataxias. The registry is at the core of a systematic multi-component ARCA database cluster with a linked biobank and an evolving study database for digital outcome measures. Currently, the registry contains more than 800 patients with almost 1,500 visits representing all ages and disease stages; 65% of patients with established genetic diagnoses capture all the main ARCA genes, and 35% with unsolved diagnoses are targets for advanced next-generation sequencing. The ARCA Registry serves as the backbone of many major European and transatlantic consortia, such as PREPARE, PROSPAX, and the Ataxia Global Initiative, with additional data input from SPORTAX. It has thus become the largest global trial-readiness registry in the ARCA field

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Critical issues in managing protected areas by multi-stakeholder participation - analysis of a process in the Swiss Alps

Balancing the frequently conflicting priorities of conservation and economic development poses a challenge to management of the Swiss Alps Jungfrau-Aletsch World Heritage Site (WHS). This is a complex societal problem that calls for a knowledge-based solution. This in turn requires a transdisciplinary research framework in which problems are defined and solved cooperatively by actors from the scientific community and the life-world. In this article we re-examine studies carried out in the region of the Swiss Alps Jungfrau-Aletsch WHS, covering three key issues prevalent in transdisciplinary settings: integration of stakeholders into participatory processes; perceptions and positions; and negotiability and implementation. In the case of the Swiss Alps Jungfrau-Aletsch WHS the transdisciplinary setting created a situation of mutual learning among stakeholders from different levels and backgrounds. However, the studies showed that the benefits of such processes of mutual learning are continuously at risk of being diminished by the power play inherent in participatory approaches

Potentials and limitations of coordinated spatial and non-spatial information

Information management and geoinformation systems (GIS) have become indispensable in a large majority of protected areas all over the world. These tools are used for management purposes as well as for research and in recent years have become even more important for visitor information, education and communication. This study is divided into two parts: the first part provides a general overview of GIS and information management in a selected number of national park organizations. The second part lists and evaluates the needs of evolving large protected areas in Switzerland. The results show a wide use of GIS and information management tools in well established protected areas. The more isolated use of singular GIS tools has increasingly been replaced by an integrated geoinformation management. However, interview partners pointed out that human resources for GIS in most parks are limited. The interviews also highlight uneven access to national geodata. The view of integrated geoinformation management is not yet fully developed in the park projects in Switzerland. Short-term needs, such as software and data availability, motivate a large number of responses collected within an exhaustive questionnaire. Nevertheless, the need for coordinated action has been identified and should be followed up. The park organizations in North America show how an effective coordination and cooperation might be organized