The Grizzly, November 22, 1985

From Damp to Bone Dry? • UCFL Takes to the Air: Or Visa Versa • It\u27s all Greek to me • The Descent on the Skunks of Ursinus • Editorial: Yale Conference a Learning Experience • Letter: Munchies Mandate • Who\u27s Who Honors Ursinus • How to Deal with Terrorists? • Two Truman Scholars • In Search of Success: Marivi Relova Brings Good Things to GE • Communication a Must • Bears Bounce Dickinson • Booters Find Cold Times in New Hampshire • Soccer Seniors Will be Missed • Coach B. is Back • Lady Bears Hope to Improve Behind Letuakas • Season Tips Off Tonight • Gymnasts Spring into Season • Alercio Faces J Board • Myrin Stacks Up • Fields Should be Ready in Spring • Immersion as Opposed to Voyeurism in Summer Study in France • Smokeless Tobacco Still Burns • Women\u27s Studies Added to Goal No. 9 • Eating Healthy at College Essential • Open Dialogs: Middle Class on Welfare?; Mercy Killing as a Solution; Birth Defects Popular With Geneticists • Ursinus College: The Marriage Factoryhttps://digitalcommons.ursinus.edu/grizzlynews/1153/thumbnail.jp

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles