Sex differences, previous experience with suicide, and attitudes towards suicide.

Although the focus of much research on suicide is increasingly on attitudes towards suicide, no theoretical model of attitudes had yet been applied. The present study applied a model of attitudes (Ajzen, 1988) to an examination of sex differences in attitudes towards suicide and the suicidal among university students regarding three components of attitudes: cognitive, affective, and conative. In addition, the relation between attitudes towards suicide and self-reported previous experience with suicide was investigated. A sample of 773 undergraduates rated a vignette of a suicidal individual (i.e., target) for the degree to which they sympathized and empathized with the target (i.e., affective), the degree to which they perceived the potential suicide as acceptable (i.e., cognitive), and whether or not they would help the individual (i.e., conative). Females had significantly higher ratings of sympathy, empathy, and intention to help than did males. When the evaluator\u27s previous experience with suicide was held constant, however, females had higher ratings of sympathy and intention to help only. Overall, the results indicate sex differences in both the affective and conative components of attitudes. These findings may begin to address the well documented sex difference in suicide completion rates as a function of attitudes, and also may have implications for primary prevention.Dept. of Psychology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1994 .W345. Source: Masters Abstracts International, Volume: 34-02, page: 0899. Adviser: Michael J. Kral. Thesis (M.A.)--University of Windsor (Canada), 1994

Study of orifice fabrication technologies for the liquid droplet radiator

Eleven orifice fabrication technologies potentially applicable for a liquid droplet radiator are discussed. The evaluation is focused on technologies capable of yielding 25-150 microns diameter orifices with trajectory accuracies below 5 milliradians, ultimately in arrays of up to 4000 orifices. An initial analytical screening considering factors such as trajectory accuracy, manufacturability, and hydrodynamics of orifice flow is presented. Based on this screening, four technologies were selected for experimental evaluation. A jet straightness system used to test 50-orifice arrays made by electro-discharge machining (EDM), Fotoceram, and mechanical drilling is discussed. Measurements on orifice diameter control and jet trajectory accuracy are presented and discussed. Trajectory standard deviations are in the 4.6-10.0 milliradian range. Electroforming and EDM appear to have the greatest potential for Liquid Droplet Radiator applications. The direction of a future development effort is discussed

Status of major southern California marine sport fish species with management recommendations, based on analyses of catch and size composition data collected on board commercial passenger fishing vessels from 1985 through 1987

This report on the status of major southern California marine sport fish species, together with management recommendations, is based on analyses of catch and size composition data, which were collected on board Commercial Passenger Fishing Vessels (CPFV) from 1985 through 1987. The project was designed to determine the status of those fishes that support the CPFV industry, and to make management recommendations when deemed necessary. We collected and analyzed data based on random, stratified, on-board sampling of weekday (excluding holidays), open CPFV's on a year-round basis. We sampled 1/2-day, 3/4-day, and full-day type trips at a level of 5%. The survey area extended from below the United States-Mexican border to Point Arguello. Catch estimates were extrapolated to include weekday as well as weekend and holiday, open and chartered CPFV's. We sampled 736 CPFV trips in 1985, 650 in 1986, and 631 in 1987. We encountered 180 species of fishes, including 49 species of rockfishes. We performed detailed analyses on 14 non-rockfish species and 12 rockfish species, as well as all fishes as a group and all rockfishes as a group. We found a moderate increase in total catch of combined fish species between this study and one in the mid-1970's, due primarily to sizeable increases in catches of Pacific mackerel, kelp bass, barred sand bass, and barracuda. However, we also found that there has been more than a 50% decline in the CPFV rockfish catches, due primarily to substantial decreases in catches of bocaccio, chilipepper, and olive rockfish. We have recommended that the current 15-rockfish bag limit regulation be reduced to a 10-rockfish bag limit, and that additional and equitable conservation measures also be implemented on the commercial rockfish fishery. (385pp.

Attitudes towards suicide: A structural model and its relationship to experience with suicide.

Two of the main approaches to understanding suicide are the sociological and the psychological. The former explains suicide as a consequence of social factors; the latter explains suicide as a consequence of individual factors. Through an examination of both social (i.e., participants\u27 exposure to the suicidal ideas and behaviour of others) and individual (i.e., participants\u27 own attitudes and experience with suicide) factors this study is one attempt to bridge these two approaches. A tripartite model of attitudes towards suicide was proposed, comprised of cognitive, affective, and conative components. A sample of 602 university students rated their attitudes towards suicide on three scales (Suicide Opinion Questionnaire; Domino, Moore, Westlake, & Gibson, 1982; Multi-Dimensional Suicide Attitude Scales and Vignettes; Stillion, 1992; Suicide Attitude Questionnaire; Diekstra & Kerkhof, 1989) as well as their past experience with suicide. Several findings were indicated. First, five factors were found to underlie suicide attitudes: Cognitive Aspects, Suicide Intent, Sympathy, Likelihood of Suicide (Others), and Likelihood of Suicide (Closest). Second, support was found for the tripartite attitudinal model. Third, having either other-experience (social) or self-experience (individual) with suicide was found to be predictive of one\u27s attitudes towards suicide. Fourth, new data on the prevalence of specific types of suicidality are provided, reinforcing the conclusion that suicidal ideation and behaviour are very common among university students. Overall, the data support the proposition of a new classificatory system for suicidal behaviour.Dept. of Psychology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2001 .W35. Source: Dissertation Abstracts International, Volume: 62-10, Section: B, page: 4845. Adviser: Michael Kral. Thesis (Ph.D.)--University of Windsor (Canada), 2001

Short-Term Exercise In Mice Increases Tibial Post-Yield Mechanical Properties While Two Weeks of Latency Following Exercise Increases Tissue-Level Strength

We have previously shown that exercise during growth increases post-yield deformation in C57BL6/129 (B6;129) male tibiae at the expense of reduced pre-yield deformation and structural and tissue strength. Other research in the literature indicates that increased mineral content, cross-sectional geometry and structural strength due to exercise can be maintained or increased after exercise ends for as long as 14 weeks. It was therefore hypothesized that after our exercise protocol ended, effects of exercise on mechanical properties would persist, resulting in increased post-yield behavior and rescued strength versus age-matched control mice. Beginning at 8 weeks of age, exercise consisted of running on a treadmill (30 min/day, 12 m/min, 5° incline) for 21 consecutive days. At the end of running and 2 weeks later, in the cortical bone of the tibial mid-diaphyses of B6;129 male mice, changes due to exercise and latency following exercise were assayed by mechanical tests and analyses of cross-sectional geometry. Exercise increased structural post-yield deformation compared with weight-matched control mice, without changes in bone size or shape, suggesting that exercised-induced changes in pre-existing bone quality were responsible. Over the 2-week latency period, no growth-related changes were noted in control mice, but exercise-induced changes resulted in increased tissue stiffness and strength versus mice sacrificed immediately after exercise ended. Our data indicate that periods of exercise followed by latency can alter strength, stiffness, and ductility of bone independent of changes in size or shape, suggesting that exercise may be a practical way to increase the quality of the bone extracellular matrix

A multiswitchable poly(terthiophene) bearing a spiropyran functionality: understanding photo and electrochemical control

An electroactive nitrospiropyran-substituted polyterthiophene, 2-(3,3′′-dimethylindoline-6′-nitrobenzospiropyranyl)ethyl 4,4′′-didecyloxy-2,2′:5′,2′′-terthiophene-3′-acetate, has been synthesized for the first time. The spiropyran, incorporated into the polymer backbone by covalent attachment to the alkoxyterthiophene monomer units, leads to multiple coloured states as a result of both electrochemical isomerization of the spiropyran moiety to merocyanine forms as well as electrochemical oxidation of the polyterthiophene backbone and the merocyanine substituents. While electrochemical polymerization of the terthiophene monomer could occurs without the apparent oxidation of the spiropyran, the subsequent electrochemistry is complex and clearly involves this substituent. In order to understand this complex behaviour, the first detailed electrochemical study of the oxidation of the precursor spiropyran, 1-(2-hydroxyethyl)-3,3-dimethylindoline-6’-nitrobenzospiropyran, was undertaken, showing that, in solution, an irreversible electrochemical oxidation of the spiropyran occurs leading to reversible redox behaviour of at least two merocyanine isomers. With these insights, an extensive electrochemical and spectroelectrochemical study of the nitrospiropyran-substituted polyterthiophene films reveals an initial irreversible electrochemical oxidative ring opening of the spiropyran to oxidized merocyanine. Subsequent reduction and cyclic voltammetry of the resulting nitromerocyanine-substituted polyterthiophene film gives rise to the formation of both merocyanine π-dimers or oligomers and π-radical cation dimers, between polymer chains. Although merocyanine formation is not electrochemically reversible, the spiropyran can be photochemically regenerated, at least in part, through irradiation with visible light. SEM and AFM images support the conclusion that the bulky spiropyran substituent is electrochemically isomerizes to the planar merocyanine moiety affording a smoother polymer film. The conductivity of the freestanding polymer film was found to be 0.4 S cm-1

Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice

Inbred strain-specific differences in mice exist in bone cross-sectional geometry, mechanical properties, and indices of bone formation. Inbred strain-specific responses to external stimuli also exist, but the role of background strain in response to genetic deletion is not fully understood. Biglycan (bgn) deficiency impacts bone through negative regulation of osteoblasts, resulting in extracellular matrix alterations and decreased mechanical properties. Because osteoblasts from C3H/He (C3H) mice are inherently more active versus osteoblasts from other inbred strains, and the bones of C3H mice are less responsive to other insults, it was hypothesized that C3H mice would be relatively more resistant to changes associated with bgn deficiency compared with C57BL6/129 (B6;129) mice. Changes in mRNA expression, tissue composition, mineral density, bone formation rate, cross-sectional geometry, and mechanical properties were studied at 8 and 11 wk of age in the tibias of male wildtype and bgn-deficient mice bred on B6;129 and C3H background strains. Bgn deficiency altered collagen cross-linking and gene expression and the amount and composition of mineral in vivo. In bgn's absence, changes in collagen were independent of mouse strain. Bgn-deficiency increased the amount of mineral in both strains, but changes in mineral composition, cross-sectional geometry, and mechanical properties were dependent on genetic background. Bgn deficiency influenced the amount and composition of bone in mice from both strains at 8 wk, but C3H mice were better able to maintain properties close to wildtype (WT) levels. By 11 wk, most properties from C3H knockout (KO) bones were equal to or greater than WT levels, whereas phenotypic differences persisted in B6;129 KO mice. This is the first study into mouse strain-specific changes in a small leucine-rich proteoglycan gene disruption model in properties across the bone hierarchy and is also one of the first to relate these changes to mechanical competence. This study supports the importance of genetic factors in determining the response to a gene deletion and defines biglycan's importance to collagen and mineral composition in vivo

Ultrastructural elastic deformation of cortical bone tissue probed by NIR Raman spectroscopy

Raman spectroscopy is used as a probe of ultrastructural (molecular) changes in both the mineral and matrix (protein and glycoprotein, predominantly type I collagen) components of murine cortical bone as it responds to loading in the elastic regime. At the ultrastructural level, crystal structure and protein secondary structure distort as the tissue is loaded. These structural changes are followed as perturbations to tissue spectra. We load tissue in a custom-made dynamic mechanical tester that fits on the stage of a Raman microprobe and can accept hydrated tissue specimens. As the specimen is loaded in tension and/or compression, the shifts in mineral P-O4v 1 and relative band heights in the Amide III band envelope are followed with the microprobe. Average load is measured using a load cell while the tissue is loaded under displacement control. Changes occur in both the mineral and matrix components of bone as a response to elastic deformation. We propose that the mineral apatitic crystal lattice is deformed by movement of calcium and other ions. The matrix is proposed to respond by deformation of the collagen backbone. Raman microspectroscopy shows that bone mineral is not a passive contributor to tissue strength. The mineral active response to loading may function as a local energy storage and dissipation mechanism, thus helping to protect tissue from catastrophic damage

Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice

Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which is independent of tissue quantity, suggests that deficiencies in tissue quality are responsible. However, the response to bgn-deficiency is inbred strain-specific. Mechanical loading influences bone matrix quality in addition to any increase in bone mass or change in bone formation activity. Since many diseases influence the mechanical integrity of bone through altered tissue quality, loading may be a way to prevent and treat extracellular matrix deficiencies. C3H/He (C3H) mice consistently have a less vigorous response to mechanical loading vs. other inbred strains. It was therefore hypothesized that the bones from both wild type (WT) and KO B6;129 mice would be more responsive to exercise than the bones from C3H mice. To test these hypotheses at 11 weeks of age, following 21 consecutive days of exercise, we investigated cross-sectional geometry, mechanical properties, and tissue composition in the tibiae of male mice bred on B6;129 and C3H backgrounds. This study demonstrated inbred strain-specific compositional and mechanical changes following exercise in WT and KO mice, and showed evidence of genotype-specific changes in bone in response to loading in a gene disruption model. This study further shows that exercise can influence bone tissue composition and/or mechanical integrity without changes in bone geometry. Together, these data suggest that exercise may represent a possible means to alter tissue quality and mechanical deficiencies caused by many diseases of bone