27 research outputs found
Clinical Application of Radioembolization in Hepatic Malignancies: Protocol for a Prospective Multicenter Observational Study
Background: Radioembolization, also known as transarterial radioembolization or selective internal radiation therapy with
yttrium-90 (90Y) resin microspheres, is an established treatment modality for patients with primary and secondary liver tumors.
However, large-scale prospective observational data on the application of this treatment in a real-life clinical setting is lacking.
Objective: The main objective is to collect data on the clinical application of radioembolization with 90Y resin microspheres
to improve the understanding of the impact of this treatment modality in its routine practice setting.
Methods: Eligible patients are 18 years or older and receiving radioembolization for primary and secondary liver tumors as
part of routine practice, as well as have signed informed consent. Data is collected at baseline, directly after treatment, and at
every 3-month follow-up until 24 months or study exit. The primary objective of the Cardiovascular and Interventional Radiological
Society of Europe Registry for SIR-Spheres Therapy (CIRT) is to observe the clinical application of radioembolization. Secondary
objectives include safety, effectiveness in terms of overall survival, progression-free survival (PFS), liver-specific PFS, imaging
response, and change in quality of life.
Results: Between January 2015 and December 2017, 1047 patients were included in the study. The 24-month follow-up period
ended in December 2019. The first results are expected in the third quarter of 2020.
Conclusions: The CIRT is the largest observational study on radioembolization to date and will provide valuable insights to
the clinical application of this treatment modality and its real-life outcomes
Measurement of Z0 decays to hadrons, and a precise determination of the number of neutrino species
We have made a precise measurement of the cross section for e+e--->Z0-->hadrons with the L3 detector at LEP, covering the range from 88.28 to 95.04 GeV. From a fit to the Z0 mass, total width, and the hadronic cross section to be MZ0=91.160 +/- 0.024 (experiment) +/-0.030(LEP) GeV, [Gamma]Z0=2.539+/-0.054 GeV, and [sigma]h(MZ0)=29.5+/-0.7 nb. We also used the fit to the Z0 peak cross section and the width todetermine [Gamma]invisible=0.548+/-0.029 GeV, which corresponds to 3.29+/-0.17 species of light neutrinos. The possibility of four or more neutrino flavors is thus ruled out at the 4[sigma] confidence level.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28683/3/0000500.pd
A measurement of the Z0 leptonic partial widths and the vector and axial vector coupling constants
We have measured the partial widths of the Z0 into lepton pairs, and the forward-backward charge asymmetry for the process e+e--->[mu]+[mu]- using the L3 detector at LEP. We obtain an average [Gamma]ll of 83.0+/-2.1+/-1.1 MeV.From this result and the asymmetry measurement, we extract the values of the vector and axial vector couplings of the Z0 to leptons: grmv=-0.066-0.027+0.046 and grmA= -0.495-0.007+0.007.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28666/3/0000483.pd
Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice
Contains fulltext :
189906.pdf (publisher's version ) (Open Access
Vergleichende Mutagenitaetsuntersuchungen nach Inhalation und intraperitonealer Applikation von Diepoxybutan und Cyclophosphamid an 3 Saeugerspezies Schlussbericht
SIGLETIB Hannover: FR 1339 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Clinical Application of Radioembolization in Hepatic Malignancies: Protocol for a Prospective Multicenter Observational Study
Background: Radioembolization, also known as transarterial radioembolization or selective internal radiation therapy with
yttrium-90 (90Y) resin microspheres, is an established treatment modality for patients with primary and secondary liver tumors.
However, large-scale prospective observational data on the application of this treatment in a real-life clinical setting is lacking.
Objective: The main objective is to collect data on the clinical application of radioembolization with 90Y resin microspheres
to improve the understanding of the impact of this treatment modality in its routine practice setting.
Methods: Eligible patients are 18 years or older and receiving radioembolization for primary and secondary liver tumors as
part of routine practice, as well as have signed informed consent. Data is collected at baseline, directly after treatment, and at
every 3-month follow-up until 24 months or study exit. The primary objective of the Cardiovascular and Interventional Radiological
Society of Europe Registry for SIR-Spheres Therapy (CIRT) is to observe the clinical application of radioembolization. Secondary
objectives include safety, effectiveness in terms of overall survival, progression-free survival (PFS), liver-specific PFS, imaging
response, and change in quality of life.
Results: Between January 2015 and December 2017, 1047 patients were included in the study. The 24-month follow-up period
ended in December 2019. The first results are expected in the third quarter of 2020.
Conclusions: The CIRT is the largest observational study on radioembolization to date and will provide valuable insights to
the clinical application of this treatment modality and its real-life outcomes