Antioxidant, Antidiabetic and Lipid Profiling of Spermadicyton Suaveolens in Streptozotocin (STZ) Induced Diabetic Rats Article

Diabetes is a life-threatening disease, and currently available synthetic medicines for treating diabetes are associated with various side effects. Therefore, there is an unmet need to develop herbal remedies against diabetes as an alternative to synthetic medicines. Although local healers use the roots of Spermadicyton suaveolens (SS) to manage diabetes, there is negligible research to validate its antidiabetic properties. The present investigation aims to the assess the antioxidant, antidiabetic, and antihyperlipidemic potential of the ethanolic extract of S. Suaveolen’s roots (EESS) on streptozotocin (STZ) induced diabetic rats. The extract was screened for in vitro antioxidant and antidiabetic activity. The in vivo antidiabetic potential of EESS (at 200 and 400 mg/kg) was studied on STZ-induced diabetic rats for 20 days. The EESS displayed significant (p<0.05) antidiabetic and antioxidant properties. The administration of 200 mg/kg and 400 mg/kg EESS in STZ-induced diabetic rats significantly reduced hyperglycemia, and restored antioxidant enzymes and lipid profile-a high density lipoprotein (HDL) increased by the administration of a single dose of streptozotocin. Thus, EESS could be a promising herbal medicine in the treatment of diabetes and hyperlipidemia

Prediction of Conflicts in Transportation Services using Real-Time Data

Smart-cities are intended to provide the comfort and satisfaction of the citizens belonging to it. There has been so many advances in the Smart-cities but still some con?icts a?ect the smart-ness of the smart- city. The problem of traffic jams in Public Transportation Services like Bus, Trains, Tubes(Metros) due to various unpredictable Realtime con?icts resulting the overall satisfaction of the user. Also, the three parallel services being independent to one another have no communication because of their distinct nature. To overcome such con?icts this paper detects and defines the key issues in smart- city public transport systems. In fact the paper is focussing on the con?icts that arise among the public transport services with three distinct providers. To monitor these services working in smart-cities, a Watch-dog architecture has been used. The Watch-dog Architecture works on detection the con?icts and returns it to the admin user to take proper decision. The Realtime data aggregated from all the three services is integrated and processed to re?ect the Runtime con?icts arising in the public transport services. This Watchdog Architecture re?ects the result in percentage by focussing on a area where all the three services integrate to result a con?ict

A randomized controlled trial to evaluate the efficacy of Karpura Ghrita as a topical analgesic with lignocaine jelly 2% in posthemorrhoidectomy pain

INTRODUCTION: Effective postoperative pain control is an essential component of the care of the surgical patient. Uncontrolled pain may cause restlessness and thereby delay in wound healing. Haemorrhoids are certainly one of the commonest ailments that afflict mankind. NSAID's have been traditionally been used to relieve pain after minor or major surgery. There are many modes of treating the local pain like by lignocaine Jelly2%, glycerine packing, diclofenac suppository which reduces the pain but they may bring delayed wound healing. The use of Karpura-Ghrita is mentioned in classics after shastrakriya for Pain (Vedana) management. Hence, this study is planned to evaluate the effect of Karpura-Ghritaan topical analgesic in post haemorrhoidectomy pain. AIM: To evaluate the analgesic effect of KarpuraGhrita OBJECTIVES: To evaluate the analgesic effect of KarpuraGhrita with Lignocaine jelly 2% gauze packing in post-operative Haemorrhoidectomy. MATERIALS AND METHODS: 30 patients who undergone haemorrhoidectomy under local anaesthesia, fulfilling the inclusion criteria were randomly selected from I.P.D of Shalyatantra of KLEU's Shri BMK Ayurveda Mahavidyalaya, Belgavi and divided into Group 1 and Group 2 comprising of 15 patients each. Group 1 (study group) was treated with KarpuraGhrita gauze packing and Group 2 (control group) was treated with lignocaine jelly 2% gauze packing after Haemorrhoidectomy. Patients were assessed for requirement of 1st dose of analgesic and Pain assessed by Verbal Descriptive Scale. OBSERVATIONS AND RESULTS: Pain score by Kruskalwallis multiple comparison test showed significant result in both the groups. Pain score between the two groups was evaluated by Mann-Whitney U test which showed non-significant result. CONCLUSION:KarpuraGhrita has shown analgesic effect. Both the drugs have shown significant effect in post haemorrhoidectomy pain management

Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.

Key PointsQuestionCan poloxamer 188, an agent that is reported to reduce blood viscosity and cell-cell interactions, effectively reduce the duration of vaso-occlusive episodes (painful crises) in hospitalized patients with sickle cell disease? FindingsIn this randomized clinical trial that included 388 children and adults with sickle cell disease, treatment with poloxamer 188 vs placebo resulted in mean time to last dose of parenteral opioids during vaso-occlusive episodes of 81.8 vs 77.8 hours, a difference that was not statistically significant. MeaningAmong patients with sickle cell disease, poloxamer 188 did not significantly shorten the duration of painful vaso-occlusive episodes

Effect of poloxamer 188 vs placebo on painful vaso-occlusive episodes in children and adults with sickle cell disease : a randomized clinical trial

Key PointsQuestionCan poloxamer 188, an agent that is reported to reduce blood viscosity and cell-cell interactions, effectively reduce the duration of vaso-occlusive episodes (painful crises) in hospitalized patients with sickle cell disease? FindingsIn this randomized clinical trial that included 388 children and adults with sickle cell disease, treatment with poloxamer 188 vs placebo resulted in mean time to last dose of parenteral opioids during vaso-occlusive episodes of 81.8 vs 77.8 hours, a difference that was not statistically significant. MeaningAmong patients with sickle cell disease, poloxamer 188 did not significantly shorten the duration of painful vaso-occlusive episodes