Fire test of timber-fibre concrete composite floor

Furnace test was performed on one full-size floor specimen at the Fire testing laboratory PAVUS. Floor specimen was 4.5 m long and 3 m wide, consisting of 60 mm fibre concrete topping on plywood formwork, connected to GL floor joists. It was subjected the standard fire for over 150 min. The membrane effect of the floor was progressively activated. The project is part of the experimental research that deals with the effect of membrane action of composite steel fibre reinforced floor slabs exposed to fire and continuous on previous research on steel fibre reinforced concrete slabs. The main objective of the project is the preparation of the analytical prediction model for the fire resistance of the steel-concrete and timber-concrete slab with steel fibre concrete

Cats and Conservationists: The Debate Over Who Owns the Outdoors

Cats and Conservationists is the first multidisciplinary analysis of the heated debate about free-roaming cats. The debate pits conservationists against cat lovers, who disagree both on the ecological damage caused by the cats and the best way to manage them. An impassioned and spirited conflict, it also sheds light on larger questions about how we interpret science, incorporate diverse perspectives, and balance competing values in order to encourage constructive dialogue on contentious social and environmental issues. On one side of the cat debate stand many environmentalists, especially birders and conservation organizations, who believe that outdoor cats seriously threaten native wildlife. On the other side are many animal welfare advocates, who believe that outdoor cats generally do not pose a major ecological threat and that it is possible for cats and wildlife to coexist. They believe that it is possible, mainly through trap-neuter-return projects (TNR), to keep free-roaming cat populations in check without killing large numbers of cats. Careful analysis suggests that there remain important questions about the science on both cat predation and TNR effectiveness. Yet both sides of the conflict insist that the evidence is clear-cut. This false certainty contributes to conflict between conservationists and cat lovers, and obscures common goals that could generate constructive discussions and collaborative efforts among scientists, policymakers, conservationists, and animal welfare advocates. Cats and Conservationists aims to facilitate such collaboration in order to manage outdoor cats and minimize the damage they cause. It also offers models for constructive debates about the public role of science in other polarized public conflicts over science and environmental topics.https://docs.lib.purdue.edu/purduepress_previews/1046/thumbnail.jp

Invasive Obstetric Procedures and Cesarean Sections in Women With Known Herpes Simplex Virus Status During Pregnancy.

BackgroundNeonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (HSV) type 1 or 2 from the maternal genital tract at the time of vaginal delivery. Current guidelines recommend (1) cesarean delivery if maternal genital HSV lesions are present at the time of labor and (2) antiviral suppressive therapy for women with known genital herpes to decrease HSV shedding from the genital tract at the time of vaginal delivery. However, most neonatal infections occur in infants born to women without a history of genital HSV, making current prevention efforts ineffective for this group. Although routine serologic HSV testing of women during pregnancy could identify women at higher risk of intrapartum viral shedding, it is uncertain how this knowledge might impact intrapartum management, and a potential concern is a higher rate of cesarean sections among women known to be HSV-2 seropositive.MethodsTo assess the effects of prenatal HSV-2 antibody testing, history of genital herpes, and use of suppressive antiviral medication on the intrapartum management of women, we investigated the frequency of invasive obstetric procedures and cesarean deliveries. We conducted a retrospective cohort study of pregnant women delivering at the University of Washington Medical center in Seattle, Washington. We defined the exposure of interest as HSV-2 antibody positivity or known history of genital herpes noted in prenatal records. The primary outcome was intrapartum procedures including fetal scalp electrode, artificial rupture of membranes, intrauterine pressure catheter, or operative vaginal delivery (vacuum or forceps). The secondary outcome was incidence of cesarean birth. Univariate and multivariable logistic regressions were performed.ResultsFrom a total of 449 women included in the analysis, 97 (21.6%) were HSV-2 seropositive or had a history of genital herpes (HSV-2/GH). Herpes simplex virus-2/GH women not using suppressive antiviral therapy were less likely to undergo intrapartum procedures than women without HSV-2/GH (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.25-0.95; P = .036), but this relationship was attenuated after adjustment for potential confounders (adjusted OR, 0.69; 95% CI, 0.34-1.41; P = .31). There was no difference in intrapartum procedures for women on suppressive therapy versus women without HSV-2/GH (OR, 1.17; 95% CI, 0.66-2.07; P = .60). Similar proportions of cesarean sections were performed within each group of women: 25% without history of HSV-2/GH, 30% on suppressive treatment, and 28.1% without suppressive treatment (global, P = .73).ConclusionsIn this single-site study, provider awareness of genital herpes infection either by HSV serotesting or history was associated with fewer invasive obstetric procedures shown to be associated with neonatal herpes, but it was not associated with an increased rate of cesarean birth

Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up

Hydrazine is carcinogenic in animals, but there is inadequate evidence to determine if it is carcinogenic in humans. This study aimed to evaluate the association between hydrazine exposure and the risk of lung cancer.The cause specific mortality rates of a cohort of 427 men who were employed at an English factory that produced hydrazine between 1945 and 1971 were compared with national mortality rates.By the end of December 2012 205 deaths had occurred. For men in the highest exposure category with greater than two years exposure and after more than ten years since first exposure the relative risks compared with national rates were: 0.85 (95% CI: 0.18-2.48) for lung cancer, 0.61 (95% CI: 0.07-2.21) for cancers of the digestive system, and 0.44 (95% CI: 0.05-1.57) for other cancers.After 50 years of follow up, the results provide no evidence of an increased risk of death from lung cancer or death from any other cause

Genital HSV Detection among HIV-1-Infected Pregnant Women in Labor

Objective. To compare genital HSV shedding among HIV-positive and HIV-negative women. Methods. Women with and without known HIV infection who delivered at the University of Washington Medical Center between 1989–1996 had HSV serologies done as part of clinical care. Genital swabs from HSV-2-seropositive women were evaluated by real-time quantitative HSV DNA PCR. Results. HSV-2 seroprevalence was 71% and 30% among 75 HIV-positive and 3051 HIV-negative women, respectively, (P < .001). HSV was detected at delivery in the genital tract of 30.8% of HIV-seropositive versus 9.5% of HIV-negative women (RR = 3.2, 95% CI 1.6 to 6.5, P = .001). The number of virion copies shed per mL was similar (log 3.54 for HIV positive versus 3.90 for HIV negative, P = .99). Conclusions. Our study demonstrated that HIV-, HSV-2-coinfected women are more likely to shed HSV at delivery

Genes invoked in the ovarian transition to menopause

Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene–protein analysis of the ovarian transition to menopause, we have established and contrasted RNA gene expression profiles and protein localization and content patterns in healthy young and perimenopausal mouse ovaries. We report a clear distinction in specific mRNA and protein levels that are noted prior to molecular evidence of steroidogenic failure. In this model, ovarian reproductive aging displays similarities with chronic inflammation and increased sensitivity to environmental cues. Overall, our results indicate the presence of mouse climacteric genes that are likely to be major players in aging-dependent changes in ovarian function

Five-Dimensional Charged Rotating Black Holes

We consider charged rotating black holes in 5-dimensional Einstein-Maxwell theory. These black holes are asymptotically flat, they possess a regular horizon of spherical topology and two independent angular momenta associated with two distinct planes of rotation. We discuss their global and horizon properties, and derive a generalized Smarr formula. We construct these black holes numerically, focussing on black holes with a single angular momentum, and with two equal-magnitude angular momenta.Comment: 13 pages, 8 figure