Classical transverse Ising spin glass with short- range interaction beyond the mean field approximation

The classical transverse field Ising spin- glass model with short-range interactions is investigated beyond the mean- field approximation for a real d- dimensional lattice. We use an appropriate nontrivial modification of the Bethe- Peierls method recently formulated for the Ising spin- glass. The zero- temperature critical value of the transverse field and the linear susceptibility in the paramagnetic phase are obtained analytically as functions of dimensionality d. The phase diagram is also calculated numerically for different values of d. In the limit d -> infinity, known mean- field results are consistently reproduced.Comment: LaTex, 11 pages, 2 figure

Associations between recalled use of legal UK youth gambling products and adult disordered gambling

Background and aims: The UK allows a number of gambling products to be legally used by people under the age of 18. The aim of this study was to explore associations between recalled legal usage of five youth gambling products and adult disordered gambling. Methods: A retrospective cross-sectional study of 1,057 adult UK gamblers, aged 18–40. Recalled legal use of five youth gambling products (category D fruit machines, coin push machines, crane grab machines, the National Lottery, and National Lottery scratchcards) was correlated with adult disordered gambling symptoms as measured by the Problem Gambling Severity Index (PGSI). Results: Recalled rates of legal engagement with each product ranged from 50.9% for Category D fruit machines to 96.6% for coin push machines. For category D fruit machines, the National Lottery, and National Lottery scratchcards, merely having legally engaged with these products as a child was associated with adult disordered gambling. Furthermore, higher levels of recalled legal youth usage with each of the five products was also associated with adult disordered gambling. Discussion and conclusions: These results relate to recent government proposals to increase the National Lottery scratchcard legal age to 18, and add to a wider literature on youth gambling and subsequent gambling-related harm

Treatment of patients with distant metastases from phyllodes tumor of the breast

BACKGROUND: Here, the treatment methods and results of patients with phyllodes tumor of the breast (PT) with distant metastases at a single institution are presented. METHODS: A retrospective analysis was performed on a group of 295 patients with PT treated from 1952 to 2010. RESULTS: Distant metastases developed in 37 (12.5 %) patients; 3/160 (1.9 %) patients had benign PT, 6/36 (16.7 %) were considered borderline, and 28/99 (28.3 %) had malignant PT. Most frequently, the metastases were located in the lungs; 28 (75.7 %), bone 7 (18.9 %), brain 4 (10.8 %), and liver 2 (5.4 %). Metastases occurred on overage 21 months (2–57) after surgery. Patients with lung metastases were generally treated with monochemotherapy or polychemotherapy. In one patient Testosterone and in two patients resection of metastases combined with Doxorubicin were used. Patients with bones or brain metastases were treated with palliative radiotherapy only or combined with Doxorubicin. The mean survival (MS) from diagnosis of distant metastases (DM) was 7 months (2–17). The longest mean survival in patients with bones metastases was 11.8 months, the worst survival was for patients with brain metastases—2.8 months. Hormone therapy appeared to have low efficacy (MS: 2 months) as well as monochemotherapy (MS: 3–5 months). Improved MS was obtained using Doxorubicin (7 months) and Doxorubicin with Cisplatin, Cyclophosphamide, or Ifosfamide (9 months). CONCLUSION: The prognosis of patients with DM from PT is poor. The role of surgery and irradiation of such patients is very limited. There appears to be no role for the use of hormone therapy. This study showed that polychemotherapy with Doxorubicin and Ifosfamide suggest that it might be more effective than once thought

History Dependent Phenomena in the Transverse Ising Ferroglass: the Free Energy Landscape

In this paper we investigate the relationship between glassy and ferromagnetic phases in disordered Ising ferromagnets in the presence of transverse magnetic fields, $\Gamma$. Iterative mean field simulations probe the free energy landscape and suggest the existence of a glass transition as a function of $\Gamma$ which is distinct from the Curie temperature. New experimental field-cooled and zero-field-cooled data on LiHo$_x$Y$_{1-x}$F$_4$ provide support for our theoretical picture.Comment: 4 pages RevTex; 5 figure

GC-MS as a tool for reliable non-invasive prenatal diagnosis of Smith-Lemli-Opitz syndrome but essential also for other cholesterolopathies verification

Rare multiple congenital malformations/developmental disorders are challenging in clinical diagnosis. The introductionof next-generation sequencing (NGS) has revolutionized this diagnostic by offering multigene panels or whole-exomesequencing. However, if there is no possibility to perform NGS or if we are facing prenatal ultrasound results, clinical diagnosticsis even more difficult. For a selected group of congenital metabolic disorders, resulting from defects in cholesterolbiosynthesis (called cholesterolopathies), application of gas chromatography-mass spectrometry (GS-MS) may provide ororientate diagnostics. The most common of these is Smith-Lemli-Opitz syndrome (SLOS), but in this publication, we alsowant to introduce other cholesterolopathies and draw attention to the possibility of non-invasive prenatal diagnosis of SLOS

Replica analysis of the generalized p-spin interaction glass model

We investigate stability of replica symmetry breaking solutions in generalized $p$-spin models. It is shown that the kind of the transition to the one-step replica symmetry breaking state depends not only on the presence or absence of the reflection symmetry of the generalized "spin"-operators $\hat{U}$ but on the number of interacting operators and their individual characteristics.Comment: 14 pages, 1 figur

Statistical risk warnings in gambling

Gambling is considered a public health issue by many researchers, similarly to alcohol or obesity. Statistical risk warnings on gambling products can be considered a public health intervention that encourages safer gambling while preserving freedom of consumer choice. Statistical risk warnings may be useful to gamblers, given that net gambling losses are the primary driver of harm and that gambling products vary greatly in the degree to which they facilitate losses. However, there is some doubt as to whether statistical risk warnings are, in their current form, effective at reducing gambling harm. Here, we consider current applications and evidence, discuss product-specific issues around a range of gambling products and suggest future directions. Our primary recommendation is that current statistical risk warnings can be improved and also applied to a wider range of gambling products. Such an approach should help consumers to make more informed judgements and potentially encourage gambling operators to compete more directly on the relative ‘price’ of gambling products