495 research outputs found

    Strengthening the 4-H Essential Elements of Positive Youth Development at Camp

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    Summer camp programs provide distinct opportunities for positive youth development through caring relationships and opportunities to build skills. To examine the extent to which youths experience the 4-H Essential Elements through 4-H camp programs, we administered the National 4-H Camping Research Consortium\u27s Camp Context Questionnaire to youths (n = 776) across 20 camps. Results indicated some exposure to the Essential Elements. Although mean scores related to establishing relationships with caring adults were high, room for improvement existed in the areas of self-determination, belonging, and personal safety. The results enabled state and local staff to implement strategic decisions for future camp programs and may be of value to others managing 4-H camp programming

    Influence of the interface on the interaction of helium-vacancy complex with metal layers of Zr/Nb

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    The first-principle calculations have been performed to investigate the influence of helium-vacancy complex on the interaction energy with zirconium and niobium. The results of calculations of vacancy formation energy and helium-vacancy complex formation energy for HCP-Zr and BCC-Nb were presented. It is established that vacancies and helium atoms occupy positions in first two Nb and Zr layers which are close to interface. It is shown that the greater number of metal layers in system has, the greater value of formation energy is

    Stability of Ferromagnetism in Hubbard models with degenerate single-particle ground states

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    A Hubbard model with a N_d-fold degenerate single-particle ground state has ferromagnetic ground states if the number of electrons is less or equal to N_d. It is shown rigorously that the local stability of ferromagnetism in such a model implies global stability: The model has only ferromagnetic ground states, if there are no single spin-flip ground states. If the number of electrons is equal to N_d, it is well known that the ferromagnetic ground state is unique if and only if the single-particle density matrix is irreducible. We present a simplified proof for this result.Comment: accepted for publication in J. Phys.

    Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

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    Small nucleolar and small Cajal body RNAs (snoRNAs and scaRNAs) of the H/ACA box and C/D box type are generated by exonucleolytic shortening of longer precursors. Removal of the last few nucleotides at the 3' end is known to be a distinct step. We report that, in human cells, knock-down of the poly(A) specific ribonuclease (PARN), previously implicated only in mRNA metabolism, causes the accumulation of oligoadenylated processing intermediates of H/ACA box but not C/D box RNAs. In agreement with a role of PARN in snoRNA and scaRNA processing, the enzyme is concentrated in nucleoli and Cajal bodies. Oligo(A) tails are attached to a short stub of intron sequence remaining beyond the mature 3' end of the snoRNAs. The noncanonical poly(A) polymerase PAPD5 is responsible for addition of the oligo(A) tails. We suggest that deadenylation is coupled to clean 3' end trimming, which might serve to enhance snoRNA stability

    Fuzzy cellular model for on-line traffic simulation

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    This paper introduces a fuzzy cellular model of road traffic that was intended for on-line applications in traffic control. The presented model uses fuzzy sets theory to deal with uncertainty of both input data and simulation results. Vehicles are modelled individually, thus various classes of them can be taken into consideration. In the proposed approach, all parameters of vehicles are described by means of fuzzy numbers. The model was implemented in a simulation of vehicles queue discharge process. Changes of the queue length were analysed in this experiment and compared to the results of NaSch cellular automata model.Comment: The original publication is available at http://www.springerlink.co

    Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis

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    To further understand the role of neuro-immunological interactions in the pathogenesis of rheumatoid arthritis (RA), we studied the influence of sympathetic neurotransmitters on cytokine production of T cells in patients with RA. T cells were isolated from peripheral blood of RA patients or healthy donors (HDs), and stimulated via CD3 and CD28. Co-incubation was carried out with epinephrine or norepinephrine in concentrations ranging from 10(-5 )M to 10(-11 )M. Interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-4, and IL-10 were determined in the culture supernatant with enzyme-linked immunosorbent assay. In addition, IFN-γ and IL-10 were evaluated with intracellular cytokine staining. Furthermore, basal and agonist-induced cAMP levels and catecholamine-induced apoptosis of T cells were measured. Catecholamines inhibited the synthesis of IFN-γ, TNF-α, and IL-10 at a concentration of 10(-5 )M. In addition, IFN-γ release was suppressed by 10(-7 )M epinephrine. Lower catecholamine concentrations exerted no significant effect. A reduced IL-4 production upon co-incubation with 10(-5 )M epinephrine was observed in RA patients only. The inhibitory effect of catecholamines on IFN-γ production was lower in RA patients as compared with HDs. In RA patients, a catecholamine-induced shift toward a Th2 (type 2) polarised cytokine profile was abrogated. Evaluation of intracellular cytokines revealed that CD8-positive T cells were accountable for the impaired catecholaminergic control of IFN-γ production. The highly significant negative correlation between age and catecholamine effects in HDs was not found in RA patients. Basal and stimulated cAMP levels in T-cell subsets and catecholamine-induced apoptosis did not differ between RA patients and HDs. RA patients demonstrate an impaired inhibitory effect of catecholamines on IFN-γ production together with a failure to induce a shift of T-cell cytokine responses toward a Th2-like profile. Such an unfavorable situation is a perpetuating factor for inflammation

    Asymmetric band gap shift in electrically addressed blue phase photonic crystal fibers

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    In this paper, we present electrooptic experiments on photonic crystal fibers filled with a liquid crystalline blue phase. These fibers guide light via photonic band gaps (PBGs). The blue phase is isotropic in the field-off state but becomes birefringent under an electric field. This leads to a polarization dependent shift of the PBGs. Interestingly, the effect on the PBGs is asymmetrical: while the short wavelength edges of the PBGs shift, the long wavelength edges are almost unaffected. By performing band gap and modal analyses via the finite element simulations, we find that the asymmetric shift is the result of the mixed polarization of the involved photonic bands. Finally, we use the band gap shifts to calculate effective Kerr constants of the blue phase

    Zes typen KOH vergeleken

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    In de zoogperiode moet geprobeerd worden het uitvalspercentage van biggen te minimaliseren. Uit onderzoek op het varkensproefbedrijf 'Noord- en Oost-Nederland' te Raalte blijkt dat het verminderen van de bewegingsruimte van de zeug het uitvalspercentage verminderd kan worde

    Vloeruitvoering in de kraamstal: kunststof of metaal

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    Op het Varkensproefbedrijf in Sterksel zijn hokken met traditionele metalen driekantrooster in volledig- en halfroosteruitvoering vergeleken met een volledig roostervloer van rond gecoate driekantroosters

    Vloeruitvoering in de kraamstal: hoeveelheid dichte vloer

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    Op het Varkensproefbedrijf in Raalte is een onderzoek afgesloten naar de vloeruitvoering in kraamhokken. De resultaten waren slechter bij toenemende hoeveelheid betonvloer. De dichte vloer mag niet langer zijn dan 120 cm en voor de biggen is beton niet het meest geschikt
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