Sintering of vesiculating pyroclasts

Hot volcanic pyroclasts can sinter, vesiculate, and outgas in concert – a combination of processes which remains poorly constrained. And yet this combination of processes can occur coincidently during deposition from pyroclastic density currents, in conduit-filling pyroclastic debris, and in tuffisites. In many of these settings, it is the sintering-driven evolution of permeability that is key to gas transport through the evolving deposit. Here, we experimentally and theoretically investigate the evolution of the permeable networks during sintering of hot fragmental volcanic systems, which are hydrous and oversaturated at the experimental conditions. Firstly, we find that vesiculation results in shutting of the inter-granular porous network as bubble growth drives expansion of the particles into one another, destroying interconnected pores. Secondly, we observe that degassing by diffusion out of the particle edge results in contraction of the vesicular particles, re-opening pore spaces between them. Therefore, we find that vesiculation, and diffusive outgassing compete to determine both the intra-fragment vesicularity and the permeability during sintering. The development of intra-fragment vesicularity directly impacts the inter-fragment pore space and its connectivity, which decreases during vesiculation and subsequently increases during diffusive outgassing, prompting complex, non-linear permeability evolution.The relative dominance of these processes is fragment size dependent; proportionally, fine fragments lose gas at a higher rate than coarser fragments during diffusive outgassing due to larger surface area to volume ratios. As the systems progress, larger fragments retain a higher proportion of gas and so attain greater vesicularities than finer ones – and therefore, the coarse fragmental pyroclasts experience a greater, yet transient, reduction in connected porosity and permeability. We suggest that where vesiculation is sufficient, it can lead to the complete loss of connected porosity and the sealing of permeable pathways much earlier than in a sintering-only system. Our results suggest that classical sintering models must be modified to account for these vesiculation and diffusive degassing processes, and that only a combined vesiculation, sintering, and diffusive outgassing model can resolve the evolution of permeability in hot clastic volcanic systems

Metallopanstimulin as a marker for head and neck cancer

BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC. PATIENTS AND METHODS: A total of 125 patients were prospectively enrolled from a university head and neck oncology clinic. Participants included only newly diagnosed HNSCC patients. Two control groups, including 25 non-smokers and 64 smokers, were studied for comparison. A total of 821 serum samples collected over a twenty-four month period were analyzed by the MPS-H radioimmunoassay. RESULTS: HNSCC, non-smokers, and smokers had average MPS-H values of 41.5 ng/mL, 10.2 ng/mL, and 12.8 ng/mL, respectively (p = 0.0001). CONCLUSION: We conclude that MPS-1 and MPS-1-like proteins are elevated in patients with HNSCC, and that MPS-H appears to be a promising marker of presence of disease and response to treatment in HNSCC patients

Shape coexistence and shape transition in self-conjugate nucleus 72Kr and the tensor force

Oblate-prolate shape-coexistence is well-known in the N=Z nucleus 72Kr. Furthermore, recent experimental data implies that there is a rapid shape transition at very low spins in this nucleus. We reinvestigate this problem by using large-scale shell-model calculations with the monopole interactions derived from the monopole-based universal force that contains the tensor force in the Hamiltonian. We show that in 72Kr, states with nucleon-quartet excitation from the pf shell to the - orbits, which favor large prolate deformation, compete with those having the pf shell as the main configuration with oblate deformation. These shapes can coexist if the two types of states reside closely in excitation energy. In 72Kr the tensor force is found to provide precisely such a coexistence condition near the ground state. As the tensor effect changes dynamically with orbital occupation when the nucleus rotates, a rapid shape transition can occur

Permeability of compacting porous lavas

The highly transient nature of outgassing commonly observed at volcanoes is in part controlled by the permeability of lava domes and shallow conduits. Lava domes generally consist of a porous outer carapace surrounding a denser lava core with internal shear zones of variable porosity. Here we examine densification using uniaxial compression experiments on variably crystalline and porous rhyolitic dome lavas from the Taupo Volcanic Zone. Experiments were conducted at 900°C and an applied stress of 3MPa to 60% strain, while monitoring acoustic emissions to track cracking. The evolution of the porous network was assessed via X-ray computed tomography, He-pycnometry, and relative gas permeability. High starting connected porosities led to low apparent viscosities and high strain rates, initially accompanied by abundant acoustic emissions. As compaction ensued, the lavas evolved; apparent viscosity increased and strain rate decreased due to strain hardening of the suspensions. Permeability fluctuations resulted from the interplay between viscous flow and brittle failure. Where phenocrysts were abundant, cracks had limited spatial extent, and pore closure decreased axial and radial permeability proportionally, maintaining the initial anisotropy. In crystal-poor lavas, axial cracks had a more profound effect, and permeability anisotropy switched to favor axial flow. Irrespective of porosity, both crystalline samples compacted to a threshold minimum porosity of 17–19%, whereas the crystal-poor sample did not achieve its compaction limit. This indicates that unconfined loading of porous dome lavas does not necessarily form an impermeable plug and may be hindered, in part by the presence of crystals

Dietary patterns across the life course, mammographic density and implications for breast cancer: results from a British prospective cohort

Background : Previous epidemiological studies have investigated the relationship between individual nutrients such as vitamin D and vitamin B12 and mammographic density, a strong marker of breast cancer risk [1], with varied results. There has been limited research on overall dietary patterns and most studies have focused on adult dietary patterns [2]. We examine prospective data to determine whether dietary patterns from childhood to adult life affect mammographic density.Methods : The Medical Research Council National Survey of Health and Development is a national representative sample of 2,815 men and 2,547 women followed since their birth in March 1946 [3]. A wealth of medical and social data has been collected in over 25 follow-ups by home visits, medical examinations and postal questionnaires. Dietary intakes at age 4 years were determined by 24-hour recalls and in adulthood (ages 36, 43 years) by 5-day food records. Copies of the mammograms (two views for each breast) taken when the women were closest to age 50 years were obtained from the relevant NHS centres. A total of 1,319 women were followed up since birth in 1946 for whom a mammogram at age 50 years was retrieved, and the percentage mammographic density was measured using the computer-assisted threshold method for all 1,161 women. Breast cancer incidence for the whole cohort is being ascertained through the National Health Service Central Register.Statistical analysis : Reduced rank regression analysis, a relatively new approach to dietary pattern analysis, is being used to identify dietary patterns associated with mammographic density [4]. This approach identifies patterns in food intake that are predictive of an intermediate outcome of the disease process, such as mammographic density, and subsequently examines the relationship between the identified dietary patterns and breast cancer risk.Results : Preliminary analyses so far suggest that variations in dietary patterns in adulthood might explain more than 10% of the variation in percentage mammographic density at age 50 years (age 36 years: 13%; age 43 years: 14%), with variations in patterns in childhood explaining slightly less. Further work is being carried out on the characteristics of these dietary patterns and their effects on percentage mammographic density and its two components (that is, absolute areas of dense and nondense tissues) and on breast cancer risk, after adjusting for socioeconomic status, anthropometric variables and reproductive factors.Conclusion : The present study will provide for the first time information on the relationship between dietary patterns across the life course and mammographic density, and will help to clarify the pathways through which diet may affect breast cancer risk.<br /

Boundary conditions at a fluid - solid interface

We study the boundary conditions at a fluid-solid interface using molecular dynamics simulations covering a broad range of fluid-solid interactions and fluid densities, and both simple and chain-molecule fluids. The slip length is shown to be independent of the type of flow, but rather is related to the fluid organization near the solid, as governed by the fluid-solid molecular interactions.Comment: REVtex, to appear in Physical Review Letter

Topological inversions in coalescing granular media control fluid-flow regimes

Sintering—or coalescence—of viscous droplets is an essential process in many natural and industrial scenarios. Current physical models of the dynamics of sintering are limited by the lack of an explicit account of the evolution of microstructural geometry. Here, we use high-speed time-resolved x-ray tomography to image the evolving geometry of a sintering system of viscous droplets, and use lattice Boltzmann simulations of creeping fluid flow through the reconstructed pore space to determine its permeability. We identify and characterize a topological inversion, from spherical droplets in a continuous interstitial gas, to isolated bubbles in a continuous liquid. We find that the topological inversion is associated with a transition in permeability-porosity behavior, from Stokes permeability at high porosity, to percolation theory at low porosity. We use these findings to construct a unified physical description that reconciles previously incompatible models for the evolution of porosity and permeability during sintering