Finite circular plate on elastic foundation centrally loaded by rigid spherical indenter

The analytical solution of a finite circular plate on an elastic foundation centrally loaded by the rigid indenter is discussed. The procedure to use NASTRAN as a subroutine to iteratively converge to this solution numerically is described

A simple element for multilayer beams in NASTRAN thermal stress analysis

In the application of NASTRAN, structural members are usually represented by bar elements with multipoint constraint cards to enforce the interface conditions. While this is a very powerful method in principle, it was found that in practice the process for specification of constraints became tedious and error prone, unless the geometry was simple and the number of grid points low. An alternative approach was found within the framework of the NASTRAN program. This approach made use of the idea that a thermal distortion in a multilayer beam may be similar to a homogeneous beam with a thermal gradient across the cross section. The exact mathematical derivation for the equivalent beam, and all the necessary formulae for the equivalent parameters in NASTRAN analysis are presented. Some numerical examples illustrate the simplicity and ease of this approach for finite element analysis

Unique Invariant Point Theorems for Random operators In Hilbert Space

We find unique common random fixed point of two random operators in closed subset of a separable Hilbert space by considering a sequence of measurable functions satisfying  Theorem 1.1 and Theorem 1.2. Keywords: Separable Hilbert space, random operators, common random fixed point

Some Result on fixed point Theorem in Hilbert Space

This paper puts up a result regarding the generalization of the Banach contraction  principle in the Hilbert space, It consist of four rational square terms in the inequality. Further the corollary of Koparde and Wag mode was obtained by considering vanishing values to some constant towards the end of this result. Keywords: Hilbert space, closed subset, Cauchy sequence, Completeness

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

Memory loss is one of the most tragic symptoms of Alzheimer's disease. Our laboratory has recently demonstrated that 'i-Extract' of Ashwagandha (Withania somnifera) restores memory loss in scopolamine (SC)-induced mice. The prime target of i-Extract is obscure. We hypothesize that i-Extract may primarily target muscarinic subtype acetylcholine receptors that regulate memory processes. The present study elucidates key target(s) of i-Extract via cellular, biochemical, and molecular techniques in a relevant amnesia mouse model and primary hippocampal neuronal cultures. Wild type Swiss albino mice were fed i-Extract, and hippocampal cells from naïve mice were treated with i-Extract, followed by muscarinic antagonist (dicyclomine) and agonist (pilocarpine) treatments. We measured dendritic formation and growth by immunocytochemistry, kallikrein 8 (KLK8) mRNA by reverse transcription polymerase chain reaction (RT-PCR), and levels of KLK8 and microtubule-associated protein 2, c isoform (MAP2c) proteins by western blotting. We performed muscarinic receptor radioligand binding. i-Extract stimulated an increase in dendrite growth markers, KLK8 and MAP2. Scopolamine-mediated reduction was significantly reversed by i-Extract in mouse cerebral cortex and hippocampus. Our study identified muscarinic receptor as a key target of i-Extract, providing mechanistic evidence for its clinical application in neurodegenerative cognitive disorders

Bulk Viscosity of Magnetized Neutron Star Matter

We study the effect of magnetic field on the bulk viscosity of nuclear matter in neutron stars. We employ the framework of relativistic mean field theory to observe the dense nuclear matter in neutron stars. The effects are first studied for the case when the magnetic field does not exceed the critical value to confine the electrons to the lowest Landau levels. We then consider the case of intense magnetic field to evaluate viscosity for the URCA processes and show that the inequality $p_{F}(e)+p_{F}(p)\geq p_{F}(n)$ is no longer required to be satisfied for the URCA processes to proceed.Comment: Latex 2e file with four postscripts figure

Cellular mechanisms underlying steroid-resistant asthma

© ERS 2019. Severe steroid-resistant asthma is clinically important, as patients with this form of the disease do not respond to mainstay corticosteroid therapies. The heterogeneity of this form of asthma and poor understanding of the pathological mechanisms involved hinder the identification of therapeutic targets and the development of more effective therapies. A major limiting factor in the understanding of severe steroid-resistant asthma is the existence of multiple endotypes represented by different immunological and inflammatory phenotypes, particularly in adults. Several clinical and experimental studies have revealed associations between specific respiratory infections and steroid-resistant asthma in adults. Here, we discuss recent findings from other authors as well as our own studies that have developed novel experimental models for interrogating the association between respiratory infections and severe steroid-resistant asthma. These models have enabled the identification of new therapies using macrolides, as well as several novel disease mechanisms, including the microRNA-21/phosphoinositide 3-kinase/histone deacetylase 2 axis and NLRP3 inflammasomes, and highlight the potential of these mechanisms as therapeutic targets

Dating Howardite Melt Clasts: Evidence for an Extended Vestan Bombardment?

Howardites are polymict breccias that, together with eucrites and diogenites (HED), likely originate from the vestan surface (regolith/ megaregolith), and display a heterogeneous distribution of eucritic and diogenitic material. Melt clasts are also present alongside other regolithic features within howardites, and are noteworthy for their compositional variability and appearance. Melt clasts formed by impact events provide a snapshot of the timings and conditions of surface gardening and bombardment on the vestan surface. By dating such clasts, we aim to better constrain the timings of impact events on Vesta, and to establish whether the impact flux in the asteroid belt was similar to that on the Moon. As the Moon is used as the basis for characterising impact models of the inner solar system, it is necessary to verify that apparent wide-scale events are seen in other planetary bodies. In particular, the observed clustering of Apollo melt clast ages between 3.8-4.0 Ga has led to two hypotheses: 1) The Moon was subjected to a sudden event - 'Lunar Cataclysm' or period of 'Late Heavy Bombardment' (LHB), 2) The age cluster represents the end of an epoch of declining bombardment or 'Heavy Bombardment. No consensus has emerged regarding one or other hypothesis. We are testing these hypotheses by seeking evidence for such events in materials other than those derived from the Moon