3 research outputs found
Disabling of the erbB Pathway Followed by IFN-γ Modifies Phenotype and Enhances Genotoxic Eradication of Breast Tumors
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model
- Author
- A. Arlt
- A. Breier
- A. C. Flachskamm, C., Holsboer, F. Linthorst
- A. Garofalo
- A. H. Winefield
- A. Jalowiec
- A. Kvikstad
- A. Molassiotis
- A. Saperstein
- A. Terao
- B. Garssen
- B. L. Andersen
- B. R. Cassileth
- C. C. Chen
- C. Thomas
- D. L. Felten
- D. M. Hodgson
- D. M. Hodgson
- D. S. Hiroto
- D. Spiegel
- E. J. Bockstaele Van
- E. Voronov
- F. Petty
- F. Schnider
- F. Vidal-Vanaclocha
- G. I. Ringdal
- G. Kothny-Wilkes
- G. P. Chrosous
- G. Tringali
- G. Tringali
- G. Kulms, D., Luger, T. A., Kubin, M. Kothny-Wilkes
- H. Faller
- H. Vetter
- I. Levav
- J. C. Levenson
- J. H. Persoons
- J. K. Kiecolt-Glaser
- J. M. Weiss
- J. P. Konsman
- J. W. Oh
- K. C. Murphy
- K. Hashimoto
- K. T. Nguyen
- K. T. Nguyen
- K. W. Pettingale
- L. C. Chang
- L. Kamen-Siegel
- L. R. Derogatis
- L. S. Sklar
- L. Y. Abramson
- L. Y. Abramson
- M. A. Andrykowski
- M. A. Visintainer
- M. D. Jacobson
- M. E. P. Seligman
- M. Ewertz
- M. G. Kavan
- M. Granerus
- M. K. Borsody
- M. M. Khan
- M. Maes
- M. Mikulincer
- M. O. Burns
- M. Petticrew
- M. Petticrew
- M. R. Jensen
- M. Wahle
- M. Watson
- M. Sato, M., Wada, Y., Takahara, J. Niimi
- Miriam Argaman
- N. C. Frank
- N. Quan
- P. D. Sweeney
- R. Grossarth-Maticek
- R. J. Gatchel
- R. J. Holden
- R. Schulz
- S. A. Everson
- S. A. Rempel
- S. F. Maier
- S. Greer
- S. Greer
- S. Greer
- S. Greer
- S. K. Lutgendorf
- S. K. Sundar
- S. K. Sundar
- S. O. Dalton
- S. Yano
- Shmuel Ariad
- T. Akech
- T. Cox
- T. Giraldi
- T. Morris
- V. H. Perry
- W. B. Kannel
- W. L. Farrar
- Y. Gidron
- Y. Saijo
- Y. Zoukos
- Yori Gidron
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2005
- Field of study
A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations of IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway
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- Publication venue
- 'UCLA American Indian Studies Center'
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