The positive soundscape project : a synthesis of results from many disciplines

This paper takes an overall view of ongoing findings from the Positive Soundscape Project, a large inter-disciplinary soundscapes study which is nearing completion. Qualitative fieldwork (soundwalks and focus groups) and lab-based listening tests have revealed that two key dimensions of the emotional response are calmness and vibrancy. In the lab these factors explain nearly 80% of the variance in listener response. Physiological validation is being sought using fMRI measurements, and these have so far shown significant differences in the response of the brain to affective and neutral soundscapes. A conceptual framework which links the key soundscape components and which could be used for future design is outlined. Metrics are suggested for some perceptual scales and possibilities for soundscape synthesis for design and user engagement are discussed, as are the applications of the results to future research and environmental noise policy

An activity-centric conceptual framework for assessing and creating positive urban soundscapes

The Positive Soundscapes Project is an interdisciplinary investigation of soundscape perception [1]. The project seeks to develop a rounded view of human perception of soundscapes by drawing together methods from the disciplines of engineering sound quality [2], acoustics, psychoacoustics, physiology [3], as well as sound art, acoustic ecology and social science [4]. In the acoustics community, sound in the environment, especially that made by other people has overwhelmingly been considered in negative terms as both intrusive and undesirable. The strong focus of traditional engineering acoustics on reducing noise levels ignores the many possibilities for characterizing positive aspects of the soundscape, whereas art and social science disciplines interpret soundscape perception as a multimodal and multi-dimensional concept. The project team come from a wide range of disciplines and are applying their experiences to investigate soundscapes from different aspects to produce a more nuanced and complete picture of listener response than has so far been achieved. In order for the team behind the project to achieve this, an underpinning framework is required, by which to approach and move the project forward, while aligning thinking from the different disciplines. This paper describes a high-level first iteration of the conceptual framework, which is structured in three parts. The use and potential application of the framework within the Positive Soundscapes Project is then discussed

Modelling the impact of atherosclerosis on drug release and distribution from coronary stents

Although drug-eluting stents (DES) are now widely used for the treatment of coronary heart disease, there remains considerable scope for the development of enhanced designs which address some of the limitations of existing devices. The drug release profile is a key element governing the overall performance of DES. The use of in vitro, in vivo, ex vivo, in silico and mathematical models has enhanced understanding of the factors which govern drug uptake and distribution from DES. Such work has identified the physical phenomena determining the transport of drug from the stent and through tissue, and has highlighted the importance of stent coatings and drug physical properties to this process. However, there is limited information regarding the precise role that the atherosclerotic lesion has in determining the uptake and distribution of drug. In this review, we start by discussing the various models that have been used in this research area, highlighting the different types of information they can provide. We then go on to describe more recent methods that incorporate the impact of atherosclerotic lesions

A Social Identity Approach to Sport Psychology: Principles, Practice, and Prospects.

Drawing on social identity theory and self-categorization theory, we outline an approach to sport psychology that understands groups not simply as features of sporting contexts but rather as elements that can be, and often are, incorporated into a person's sense of self and, through this, become powerful determinants of their sport-related behavior. The underpinnings of this social identity approach are outlined, and four key lessons for sport that are indicative of the analytical and practical power of the approach are presented. These suggest that social identity is the basis for sports group (1) behavior, (2) formation and development, (3) support and stress appraisal, and (4) leadership. Building on recent developments within sport science, we outline an agenda for future research by identifying a range of topics to which the social identity approach could fruitfully contribute

Profit enhancing competitive pressure in vertically related industries

Coevolution of viruses and their hosts represents a dynamic molecular battle between the immune system and viral factors that mediate immune evasion. After the abandonment of smallpox vaccination, cowpox virus infections are an emerging zoonotic health threat, especially for immunocompromised patients. Here we delineate the mechanistic basis of how cowpox viral CPXV012 interferes with MHC class I antigen processing. This type II membrane protein inhibits the coreTAP complex at the step after peptide binding and peptide-induced conformational change, in blocking ATP binding and hydrolysis. Distinct from other immune evasion mechanisms, TAP inhibition is mediated by a short ER-lumenal fragment of CPXV012, which results from a frameshift in the cowpox virus genome. Tethered to the ER membrane, this fragment mimics a high ER-lumenal peptide concentration, thus provoking a trans-inhibition of antigen translocation as supply for MHC I loading. These findings illuminate the evolution of viral immune modulators and the basis of a fine-balanced regulation of antigen processing

The positive soundscape project

The Positive Soundscape Project is a multi-disciplinary investigation of soundscape perception which started in October 2006. This paper communicates the aims and design of the project and discusses some early results. The project seeks to develop a rounded view of human perception of soundscapes by combining methods from several disciplines. This will involve a move away from measuring sound just as noise. In this respect artistic and ethnographic conceptions of the soundscape are more advanced than mainstream acoustic ones. (While acoustics is tentatively moving away from LAeq as the sole descriptor, artists have interpreted soundscape perception as multi-modal and multi-dimensional from the beginning.) Thus, the PSP work uses methods from sound art, acoustic ecology and social science as well as techniques from acoustics, psychoacoustics, physiology, neuroimaging and sound quality. The project has an unusual design in that there is a two-way exchange between the different disciplines. For example, an artistically conceived 'soundtoy' will be used to stimulate discussion in social science focus groups and to inspire laboratory psychoacoustic experiments. A pilot investigation of an urban soundscape in the UK has been conducted and preliminary conclusions will be drawn on the benefits and problems of an intensely inter-disciplinary approach