627 research outputs found
Relationship Value, Trust And Supplier Retention In South African Automotive Supply Chains
Suppliers have a particular role to play in assuring competitiveness in supply chains. This article investigates the relationship between first and second tier suppliers in automotive supply chains in South Africa. Automotive component suppliers (first tier suppliers to assemblers (OEMS) such as Toyota) should make an extra effort to retain their suppliers (second tier), particularly suppliers of strategic parts, to assure the best value adding by the suppliers in the highly competitive supply chain landscape. To assure best value from suppliers they need to be retained in an active trusting, long term, collaborative relationship. The more the customer trusts the supplier, the higher the perceived value of the relationship and the more likely parties will work together to retain the business relationship. The aim of this quantitative study amongst first tier suppliers is to obtain more insight into the relationships and the hierarchical correlation between the relationship value, trust and supplier retention in automotive supply chains in South Africa. With a regression analysis it was found that both trust and relationship value are substantial predictors of supplier retention, but trust is more important for supplier retention
Advanced technologies for future ground-based, laser-interferometric gravitational wave detectors
We present a review of modern optical techniques being used and developed for the field of gravitational wave detection. We describe the current state-of-the-art of gravitational waves detector technologies with regard to optical layouts, suspensions and test masses. We discuss the dominant sources and noise in each of these subsystems and the developments that will help mitigate them for future generations of detectors. We very briefly summarise some of the novel astrophysics that will be possible with these upgraded detectors
Comparison of cryogenic deformation of the concentrated solid solutions CoCrFeMnNi, CoCrNi and CoNi
Stokes Diagnostis of 2D MHD-simulated Solar Magnetogranulation
We study the properties of solar magnetic fields on scales less than the
spatial resolution of solar telescopes. A synthetic infrared
spectropolarimetric diagnostics based on a 2D MHD simulation of
magnetoconvection is used for this. We analyze two time sequences of snapshots
that likely represent two regions of the network fields with their immediate
surrounding on the solar surface with the unsigned magnetic flux density of 300
and 140 G. In the first region we find from probability density functions of
the magnetic field strength that the most probable field strength at logtau_5=0
is equal to 250 G. Weak fields (B < 500 G) occupy about 70% of the surface,
while stronger fields (B 1000 G) occupy only 9.7% of the surface. The magnetic
flux is -28 G and its imbalance is -0.04. In the second region, these
parameters are correspondingly equal to 150 G, 93.3 %, 0.3 %, -40 G, and -0.10.
We estimate the distribution of line-of-sight velocities on the surface of log
tau_5=-1. The mean velocity is equal to 0.4 km/s in the first simulated region.
The averaged velocity in the granules is -1.2 km/s and in the intergranules is
2.5 km/s. In the second region, the corresponding values of the mean velocities
are equal to 0, -1.8, 1.5 km/s. In addition we analyze the asymmetry of
synthetic Stokes-V profiles of the Fe I 1564.8 nm line. The mean values of the
amplitude and area asymmetry do not exceed 1%. The spatially smoothed amplitude
asymmetry is increased to 10% while the area asymmetry is only slightly varied.Comment: 24 pages, 12 figure
Toward scalable quantum computation with cavity QED systems
We propose a scheme for quantum computing using high-Q cavities in which the
qubits are represented by single cavity modes restricted in the space spanned
by the two lowest Fock states. We show that single qubit operations and
universal multiple qubit gates can be implemented using atoms sequentially
crossing the cavities.Comment: 14 pages, 8 figure
Implementation of an Optimal First-Order Method for Strongly Convex Total Variation Regularization
We present a practical implementation of an optimal first-order method, due
to Nesterov, for large-scale total variation regularization in tomographic
reconstruction, image deblurring, etc. The algorithm applies to -strongly
convex objective functions with -Lipschitz continuous gradient. In the
framework of Nesterov both and are assumed known -- an assumption
that is seldom satisfied in practice. We propose to incorporate mechanisms to
estimate locally sufficient and during the iterations. The mechanisms
also allow for the application to non-strongly convex functions. We discuss the
iteration complexity of several first-order methods, including the proposed
algorithm, and we use a 3D tomography problem to compare the performance of
these methods. The results show that for ill-conditioned problems solved to
high accuracy, the proposed method significantly outperforms state-of-the-art
first-order methods, as also suggested by theoretical results.Comment: 23 pages, 4 figure
Multi-gap superconductivity in a BaFe1.84Co0.16As2 film from optical measurements at terahertz frequencies
We measured the THz reflectance properties of a high quality epitaxial thin
film of the Fe-based superconductor BaFeCoAs with
T=22.5 K. The film was grown by pulsed laser deposition on a DyScO
substrate with an epitaxial SrTiO intermediate layer. The measured
spectrum, i.e. the reflectivity ratio between the superconducting and
normal state reflectance, provides clear evidence of a superconducting gap
close to 15 cm. A detailed data analysis shows that a
two-band, two-gap model is absolutely necessary to obtain a good description of
the measured spectrum. The low-energy gap results to be
well determined (=15.50.5 cm), while the value of the
high-energy gap is more uncertain (=557 cm).
Our results provide evidence of a nodeless isotropic double-gap scenario, with
the presence of two optical gaps corresponding to 2 values close
to 2 and 7.Comment: Published Versio
In silico design of Phl p 6 variants with altered Fold-Stability significantly impacts antigen processing, immunogenicity and immune polarization
Introduction: Understanding, which factors determine the immunogenicity and immune polarizing properties of proteins, is an important prerequisite for designing better vaccines and immunotherapeutics. While extrinsic immune modulatory factors such as pathogen associated molecular patterns are well-understood, far less is known about the contribution of protein inherent features. Protein fold-stability represents such an intrinsic feature contributing to immunogenicity and immune polarization by influencing the amount of peptide-MHC II complexes (pMHCII). Here, we investigated how modulation of the fold-stability of the grass pollen allergen Phl p 6 affects its ability to stimulate immune responses and T cell polarization.
Methods: MAESTRO software was used for in silico prediction of stabilizing or destabilizing point mutations. Mutated proteins were expressed in E. coli, and their thermal stability and resistance to endolysosomal proteases was determined. Resulting peptides were analyzed by mass spectrometry. The structure of the most stable mutant protein was assessed by X-ray crystallography. We evaluated the capacity of the mutants to stimulate T cell proliferation in vitro, as well as antibody responses and T cell polarization in vivo in an adjuvant-free BALB/c mouse model.
Results: In comparison to wild-type protein, stabilized or destabilized mutants displayed changes in thermal stability ranging from â5 to +14°. While highly stabilized mutants were degraded very slowly, destabilization led to faster proteolytic processing in vitro. This was confirmed in BMDCs, which processed and presented the immunodominant epitope from a destabilized mutant more efficiently compared to a highly stable mutant. In vivo, stabilization resulted in a shift in immune polarization from TH2 to TH1/TH17 as indicated by higher levels of IgG2a and increased secretion of TNF-α, IFN-Îł, IL-17, and IL-21.
Conclusion: MAESTRO software was very efficient in detecting single point mutations that increase or reduce fold-stability. Thermal stability correlated well with the speed of proteolytic degradation and presentation of peptides on the surface of dendritic cells in vitro. This change in processing kinetics significantly influenced the polarization of T cell responses in vivo. Modulating the fold-stability of proteins thus has the potential to optimize and polarize immune responses, which opens the door to more efficient design of molecular vaccines
The Intentional Use of Service Recovery Strategies to Influence Consumer Emotion, Cognition and Behaviour
Service recovery strategies have been identified as a critical factor in the success of. service organizations. This study develops a conceptual frame work to investigate how specific service recovery strategies influence the emotional, cognitive and negative behavioural responses of . consumers., as well as how emotion and cognition influence negative behavior. Understanding the impact of specific service recovery strategies will allow service providers' to more deliberately and intentionally engage in strategies that result in positive organizational outcomes. This study was conducted using a 2 x 2 between-subjects quasi-experimental design. The results suggest that service recovery has a significant impact on emotion, cognition and negative behavior. Similarly, satisfaction, negative emotion and positive emotion all influence negative behavior but distributive justice has no effect
Symmetries of a class of nonlinear fourth order partial differential equations
In this paper we study symmetry reductions of a class of nonlinear fourth
order partial differential equations \be u_{tt} = \left(\kappa u + \gamma
u^2\right)_{xx} + u u_{xxxx} +\mu u_{xxtt}+\alpha u_x u_{xxx} + \beta u_{xx}^2,
\ee where , , , and are constants. This
equation may be thought of as a fourth order analogue of a generalization of
the Camassa-Holm equation, about which there has been considerable recent
interest. Further equation (1) is a ``Boussinesq-type'' equation which arises
as a model of vibrations of an anharmonic mass-spring chain and admits both
``compacton'' and conventional solitons. A catalogue of symmetry reductions for
equation (1) is obtained using the classical Lie method and the nonclassical
method due to Bluman and Cole. In particular we obtain several reductions using
the nonclassical method which are no} obtainable through the classical method
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