An Optical Study of Two VY Sculptoris-Type Cataclysmic Binary Stars: V704 And and RX J2338+431

We report observations of the known cataclysmic variable star (CV) V704 And, and also confirm that the optical counterpart of the ROSAT Galactic Plane Survey source RX J2338+431 is a heretofore-neglected CV. Photometric and spectroscopic observations from MDM Observatory show both systems to be novalike variables that exhibit dips of 4-5 magnitudes from their mean brightnesses, establishing them as members of the VY~Scl subclass. From high-state emission-line radial velocities, we determine orbital periods of 0.151424(3) d (3.63 hr) for V704 And and 0.130400(1) d (3.13 hr) for RX J2338+431. In V704 And, we find that the H-alpha emission-line measures cluster into distinct regions on a plot of equivalent width versus full width at half-maximum, which evidently correspond to high, intermediate, and low photometric states. This allows us to assign spectra to photometric states when contemporaneous photometry is not available, an apparently novel method that may be useful in studies of other novalikes. Our low-state spectra of RX J2338+431 show features of an M-type secondary star, from which we estimate a distance of 890 +- 200 pc, in good agreement with the Gaia DR2 parallax.Comment: Accepted for Astronomical Journa

SL(2,C) Chern-Simons theory and the asymptotic behavior of the colored Jones polynomial

We clarify and refine the relation between the asymptotic behavior of the colored Jones polynomial and Chern-Simons gauge theory with complex gauge group SL(2,C). The precise comparison requires a careful understanding of some delicate issues, such as normalization of the colored Jones polynomial and the choice of polarization in Chern-Simons theory. Addressing these issues allows us to go beyond the volume conjecture and to verify some predictions for the behavior of the subleading terms in the asymptotic expansion of the colored Jones polynomial.Comment: 15 pages, 7 figure

Effective Action and Holography in 5D Gauge Theories

We apply the holographic method to 5D gauge theories on the warped interval. Our treatment includes the scalars associated with the fifth gauge field component, which appear as 4D Goldstone bosons in the holographic effective action. Applications are considered to two classes of models in which these scalars play an important role. In the Composite-Higgs (and/or Gauge-Higgs Unification) scenario, the scalars are interpreted as the Higgs field and we use the holographic recipe to compute its one-loop potential. In AdS/QCD models, the scalars are identified with the mesons and we compute holographically the Chiral Perturbation Theory Lagrangian up to p^4 order. We also discuss, using the holographic perspective, the effect of including a Chern-Simons term in the 5D gauge Lagrangian. We show that it makes a Wess-Zumino-Witten term to appear in the holographic effective action. This is immediately applied to AdS/QCD, where a Chern-Simons term is needed in order to mimic the Adler-Bardeen chiral anomaly.Comment: 37 pages; v2, minor changes, one reference added; v3, minor corrections, version published in JHE

Prostate cancer treatment with Irreversible Electroporation (IRE): Safety, efficacy and clinical experience in 471 treatments.

BackgroundIrreversible Electroporation (IRE) is a novel image-guided tissue ablation technology that induces cell death via very short but strong pulsed electric fields. IRE has been shown to have preserving properties towards vessels and nerves and the extracellular matrix. This makes IRE an ideal candidate to treat prostate cancer (PCa) where other treatment modalities frequently unselectively destroy surrounding structures inducing severe side effects like incontinence or impotence. We report the retrospective assessment of 471 IRE treatments in 429 patients of all grades and stages of PCa with 6-year maximum follow-up time.Material and findingsThe patient cohort consisted of low (25), intermediate (88) and high-risk cancers (312). All had multi-parametric magnetic resonance imaging, and 199 men had additional 3D-mapping biopsy for diagnostic work-up prior to IRE. Patients were treated either focally (123), sub-whole-gland (154), whole-gland (134) or for recurrent disease (63) after previous radical prostatectomy, radiation therapy, etc. Adverse effects were mild (19.7%), moderate (3.7%) and severe (1.4%), never life-threatening. Urinary continence was preserved in all cases. IRE-induced erectile dysfunction persisted in 3% of the evaluated cases 12 months post treatment. Mean transient IIEF-5-Score reduction was 33% within 12-month post IRE follow-up and 15% after 12 months. Recurrences within the follow-up period occurred in 10% of the treated men, 23 in or adjacent to the treatment field and 18 outside the treatment field (residuals). Including residuals for worst case analysis, Kaplan Maier estimation on recurrence rate at 5 years resulted in 5.6% (CI95: 1.8-16.93) for Gleason 6, 14.6% (CI95: 8.8-23.7) for Gleason 7 and 39.5% (CI95: 23.5-61.4) for Gleason 8-10.ConclusionThe results indicate comparable efficacy of IRE to standard radical prostatectomy in terms of 5-year recurrence rates and better preservation of urogenital function, proving the safety and suitability of IRE for PCa treatment. The data also shows that IRE, besides focal therapy of early PCa, can also be used for whole-gland ablations, in patients with recurrent PCa, and as a problem-solver for local tumor control in T4-cancers not amenable to surgery and radiation therapy anymore

Transplantation in children

Kidney transplantation in very young children, less than 2 years of age, has usually failed, mainly because of difficulties maintaining these patients on hemodialysis long enough to permit retransplantation after loss of the original graft. Liver replacement in the very young child has been associated with a higher frequency of vascular and biliary obstruction than in the older child, due to the small size of these structures. Such accidents have contributed to unsatisfactory results with biliary atresia. Transplantation of kidney or liver into older children has been more successful than transplantation of these organs into adults. Related or cadaveric kidney transplantation in the child has been followed by at least a 60 per cent patient survival for 6 to 13 years and a very acceptable quality of life. Liver replacement for diseases other than biliary atresia has been followed by a 56 per cent 1 year survival rate, and two children have survived for more than 5 years

A central limit theorem for the zeroes of the zeta function

On the assumption of the Riemann hypothesis, we generalize a central limit theorem of Fujii regarding the number of zeroes of Riemann's zeta function that lie in a mesoscopic interval. The result mirrors results of Soshnikov and others in random matrix theory. In an appendix we put forward some general theorems regarding our knowledge of the zeta zeroes in the mesoscopic regime.Comment: 22 pages. Incorporates referees suggestions. Contains minor corrections to published versio

Cosmological Evolution of Supergiant Star-Forming Clouds

In an exploration of the birthplaces of globular clusters, we present a careful examination of the formation of self-gravitating gas clouds within assembling dark matter haloes in a hierarchical cosmological model. Our high-resolution smoothed particle hydrodynamical simulations are designed to determine whether or not hypothesized supergiant molecular clouds (SGMCs) form and, if they do, to determine their physical properties and mass spectra. It was suggested in earlier work that clouds with a median mass of several 10^8 M_sun are expected to assemble during the formation of a galaxy, and that globular clusters form within these SGMCs. Our simulations show that clouds with the predicted properties are indeed produced as smaller clouds collide and agglomerate within the merging dark matter haloes of our cosmological model. We find that the mass spectrum of these clouds obeys the same power-law form observed for globular clusters, molecular clouds, and their internal clumps in galaxies, and predicted for the supergiant clouds in which globular clusters may form. We follow the evolution and physical properties of gas clouds within small dark matter haloes up to z = 1, after which prolific star formation is expected to occur. Finally, we discuss how our results may lead to more physically motivated "rules" for star formation in cosmological simulations of galaxy formation.Comment: Accepted to The Astrophysical Journal; 17 pages, 8 figure