22 research outputs found
Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: The OPTIPARK open-label study
- Author
- Bartels C
- Barth A
- Barth K
- Behrens S
- Bergmann A
- Bodenschatz R
- Born R
- Brandt M
- Brock S
- Brockmeier B
- Brücke C
- Brüggemann N
- Bungard U
- Bühler B
- Cepek L
- Claus IS
- Csoti I
- Deist M
- Domke S
- Dzialowski I
- Dölle U
- Ebersbach G
- Eggert H
- Eggert K
- Ehret R
- Engel J
- Fietzek U
- Friedrich A
- Fritzinger M
- Gandor F
- Gehring K
- Gierer S
- Gierer S
- Gjaurov V
- Gruber D
- Günes Ö
- Haas T
- Hahn K
- Haraszti AE
- Hartmann R
- Haslinger B
- Heiss E
- Herbst HP
- Hoffmann F
- Hofmann WE
- Höglinger G
- Jost W
- Kavcic AM
- Kellinghaus C
- Klemperer B
- Klostermann F
- Knoll T
- Koleva-Alazeh N
- Koschel J
- Kraft-Safavi DW
- Kronenberger A
- Kupsch A
- Kühn A
- Laumen P
- Lees A
- Lehnhoff T
- Lingor P
- Lippmann K
- Lorrain M
- Maass F
- Magalhães D
- Muhlack S
- Müller T
- Nagel M
- Neudecker S
- Odin K
- Oehlwein C
- Orbasli H
- Pape H
- Pfister R
- Prell T
- Puzich R
- Rau D
- Reese R
- Reichmann H
- Reifschneider G
- Reimann G
- Reimers CD
- Rewitzer C
- Ries S
- Rieth C
- Rocha JF
- Safavi A
- Schmied AB
- Schrey C
- Schwarz J
- Schwarz W
- Soares-Da-Silva P
- Springub J
- Tadic V
- Tiel-Wilck K
- Tröger J
- Tönges L
- Von Pannwitz W
- Zolnai CA
- Publication venue
- Publication date
- 01/01/2020
- Field of study
BACKGROUND: The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evidence from routine practice is needed to complement the data from the pivotal trials. METHODS: OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice conditions. Patients with Parkinson’s disease and motor fluctuations were treated with opicapone 50 mg for 3 (Germany) or 6 (UK) months in addition to their current levodopa and other antiparkinsonian treatments. The primary endpoint was the Clinician’s Global Impression of Change (CGI-C) after 3 months. Secondary assessments included Patient Global Impressions of Change (PGI-C), the Unified Parkinson’s Disease Rating Scale (UPDRS), Parkinson’s Disease Questionnaire (PDQ-8), and the Non-Motor Symptoms Scale (NMSS). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs). RESULTS: Of the 506 patients enrolled, 495 (97.8%) took at least one dose of opicapone. Of these, 393 (79.4%) patients completed 3 months of treatment. Overall, 71.3 and 76.9% of patients experienced any improvement on CGI-C and PGI-C after 3 months, respectively (full analysis set). At 6 months, for UK subgroup only (n = 95), 85.3% of patients were judged by investigators as improved since commencing treatment. UPDRS scores at 3 months showed statistically significant improvements in activities of daily living during OFF (mean ± SD change from baseline: − 3.0 ± 4.6, p < 0.0001) and motor scores during ON (− 4.6 ± 8.1, p < 0.0001). The mean ± SD improvements of − 3.4 ± 12.8 points for PDQ-8 and -6.8 ± 19.7 points for NMSS were statistically significant versus baseline (both p < 0.0001). Most of TEAEs (94.8% of events) were of mild or moderate intensity. TEAEs considered to be at least possibly related to opicapone were reported for 45.1% of patients, with dyskinesia (11.5%) and dry mouth (6.5%) being the most frequently reported. Serious TEAEs considered at least possibly related to opicapone were reported for 1.4% of patients. CONCLUSIONS: Opicapone 50 mg was effective and generally well-tolerated in PD patients with motor fluctuations treated in clinical practice. TRIAL REGISTRATION: Registered in July 2016 at clinicaltrials.gov (NCT02847442)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
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- Altieri DC
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- Alves S
- Alzaharna MM
- Amadio M
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- Ambrosio S
- Amer AO
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Comprehensive molecular characterization of the hippo signaling pathway in cancer
- Author
- Abdel-Rahman MH
- Abeshouse A
- Adebamowo C
- Adebamowo SN
- Agnew K
- Ahn K
- Ajani JA
- Akbani R
- Akeredolu T
- Al-Ahmadie H
- Albert M
- Alexopoulou I
- Ally A
- Alvaro D
- Anderson ML
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- Appelbaum EL
- Aredes ND
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- Asa SL
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- Barnholtz-Sloan JS
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- Penny R
- Perin A
- Perou AH
- Perou CM
- Petersen G
- Peterson L
- Peto M
- Phillips J
- Phillips SM
- Phu BD
- Piché A
- Pickens A
- Pihl T
- Pilarski R
- Pinero EMM
- Pinto PA
- Pirtac M
- Pollo B
- Pool M
- Porten S
- Postier R
- Potapova O
- Powers J
- Prados M
- Prince M
- Que F
- Quinn M
- Quintero-Aguilo M
- Rabeno B
- Rai K
- Ramalingam S
- Ramirez NC
- Ramondetta L
- Rao A
- Rassl DM
- Rathmell WK
- Raut CP
- Raymond D
- Reis RM
- Reuter V
- Reynolds S
- Reznik E
- Rice D
- Richards WG
- Rintoul RC
- Rivera M
- Roach J
- Roberts L
- Robertson AG
- Robinson B
- Roggin K
- Roman-Roman S
- Rosenthal HG
- Rozek L
- Rubin MA
- Ryan M
- Saad F
- Sadeghi S
- Saksena G
- Sanchez-Vega F
- Sander C
- Sankarankuty A
- Santibanez J
- Sastre X
- Sauter G
- Saw R
- Scapulatempo-Neto C
- Scarpace L
- Schadendorf D
- Schein JE
- Schiffman M
- Schilero C
- Schlomm T
- Schmidt HK
- Schmidt LS
- Schoenfield L
- Schultz N
- Schumacher SE
- Scolyer R
- Secord A
- Seder CW
- Sekhon H
- Senecal K
- Sepulveda A
- Setdikova G
- Sexton KC
- Shabunin A
- Shannon K
- Sharp A
- Shelley CS
- Shelton C
- Shelton T
- Shen H
- Sheridan R
- Sherman M
- Sheth M
- Shi Y
- Shih J
- Shimmel K
- Shin DM
- Shinbrot E
- Shipman C
- Shmulevich I
- Shriver CD
- Sica G
- Sifri S
- Sigmund R
- Signoretti S
- Silveira HCS
- Simko J
- Simon R
- Simons JV
- Singer S
- Singh B
- Singh R
- Sipahimalani P
- Skelly T
- Sloan AE
- Slotta-Huspenina J
- Smallridge R
- Smith J
- Smith-McCune K
- Smolenski K
- Smyrk T
- Sofia HJ
- Soloway MG
- Somiari S
- Sood A
- Spellman P
- Spillane A
- Stancul I
- Stanton M
- Staugaitis SM
- Steele R
- Stepa S
- Stern M-H
- Stoehr C
- Stoehr R
- Stoop H
- Stretch J
- Stuart JM
- Su T
- Sumer SO
- Sun Q
- Sun Y
- Swanson P
- Swisher E
- Synott M
- Tam A
- Tamakawa R
- Tamboli P
- Tan D
- Tang Y
- Tarnuzzer R
- Taubert H
- Tavobilov M
- Taylor BS
- Tcaciuc D
- Tennstedt P
- Thiessen N
- Thomas G
- Thompson E
- Thompson J
- Thompson RH
- Thompson T
- Thorp R
- Thorsson V
- Tien NV
- Timmers H
- Tirapelli D
- Tischler A
- Torbenson M
- Troncoso P
- Tsang YH
- Tsao A
- Tse K
- Tucker K
- Têtu B
- Unterberg A
- Urba W
- Valdivieso F
- Van Bang N
- Van Den Berg DJ
- van Kessel KE
- Van Meir EG
- Van Tine B
- VandenBerg S
- Veluvolu U
- Vicha A
- Vidal DO
- Vocke CD
- Voet D
- von Deimling A
- Voronina O
- Wach S
- Wakely P
- Waldmann J
- Walker J
- Wan Y
- Wang J
- Wang J
- Wang L
- Wang M
- Wang T
- Wang Y
- Wang Z
- Warnick R
- Weinstein JN
- Weisenberger DJ
- Wentzensen N
- Westervelt P
- Wheeler DA
- Wilkerson MD
- Williams F
- Wilmott J
- Wilson RK
- Wise L
- Wistuba I
- Wiznerowicz M
- Wolf G
- Wolinsky Y
- Wong CK
- Wong T
- Worrell R
- Wu Y
- Wullich B
- Xi L
- Xu X
- Yang H
- Yang I
- Yang JD
- Yang L
- Yau C
- Yena P
- Zach LA
- Zaren H
- Zelinka T
- Zenklusen JC
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang JJ
- Zhang L
- Zhang W
- Zhao F
- Zhou W
- Zmuda E
- Zuna R
- Zwarthoff EC
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era
The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets
- Publication venue
- 'American Society of Hematology'
- Publication date
- Field of study
Macrothrombocytopenia in North India: Role of Automated Platelet Data in the Detection of an Under Diagnosed Entity
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Inherited Giant Platelet Disorders
- Author
- Asch AS
- Becker SP
- Beer JH
- Berger G
- Berhein J
- Bernard J
- Bernard J
- Berndt MC
- Boccaccio P
- Breton-Gorius J
- Brivet F
- Budarf
- Cabrera JR
- Clemetson
- Clezardin P
- Coller BS
- Coller BS
- DiMichele DM
- Ducrou W
- Epstein CJ
- Facon T
- Fauvel-Lafeve F
- Fox
- Fujita Y
- Gebrane-Younes J
- George JN
- Gershoni-Baruch R
- Gilman Al
- Gootenberg JE
- Goto S
- Greinacher A
- Greinacher A
- Grever MJW
- Gröttum KA
- Hamilton WR
- Hegglin R
- Heynen JM
- Hickey MJ
- Jantunen E
- Kehrel B
- Khalil HS
- Kirchmaier CM
- Kohler M
- Kunishima
- Lacombe M
- Lages
- Lanza F
- Levy-Toledanos S
- Lévy
- Lévy
- López JA
- López JA
- Martinez-Marillo C
- May R
- McDunn S
- McKeown L
- Miller
- Milton GJ
- Milton JG
- Mitsui T
- Mori K
- Noda M
- Noris P
- Noris P
- Nurden P
- Okita JR
- Parsa KP
- Peaceman AM
- Peterson CL
- Pfueller
- Pujol-Moix N
- Raccuglia G
- Ricci G
- Rosa JP
- Ryan
- Saade G
- Takashima T
- Tandon
- Tomer A
- Tsoi W
- Urato CA
- Van Geet
- Von Behrens WE
- Von Behrens WE
- Ware J
- Weiss HJ
- Wenger
- White JG
- White JG
- White JG
- Yagi M
- Yufu Y
- Publication venue
- 'American Society for Clinical Pathology (ASCP)'
- Publication date
- Field of study
In the Beginning …
- Author
- AL Burnett
- AL Jacobson
- AS Brink
- AS Romer
- AW Crompton
- AW Crompton
- BK Napier
- BK Napier
- CO Lovejoy
- CU Ariens Kappers
- D Johanson
- D Johanson
- DE Clayton
- E Hoyle
- F Brown
- G Constable
- GC Reid
- GH Bishop
- GS Paul
- H Vallada
- HG Bandi
- J Gribbin
- J Pfeiffer
- JC Quiroga
- JC Quiroga
- JD Watson
- JE Lovelock
- JH Orton
- JV McConnel
- JV McConnel
- JW Papez
- JW Schopf
- K Frisch Von
- K Frisch Von
- L Binford
- L Margulis
- L Miller
- L Miller
- LH Hyman
- M Davis
- MC Behrens
- P Lieberman
- P Lieberman
- P Maclean
- PB Applewhite
- R Broom
- R Dawkins
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Ornstein
- R Prideaux
- RE Leakey
- RH Emson
- RL Hay
- RT Bakker
- RT Bakker
- S Weinberg
- SS Schneider
- SS Schneider
- TL Lentz
- VJ Maglio
- W Alvarez
- WE Scheele
- WH Kimbel
- WM Irvine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1993
- Field of study
Biochemical Studies on Autism
- Author
- A Halevy
- A Nakeff
- A Pletscher
- A Rotman
- A Wirz-Justice
- A Yuwiler
- A Yuwiler
- A Yuwiler
- A Yuwiler
- AH Chapman
- AR Lucas
- AW Lis
- B Fish
- B Garreau
- B Rimland
- B Rimland
- BA Shaywitz
- BG Winsberg
- BJ Haverback
- BV Clineschmidt
- C Gillberg
- C Shaw
- C Sotelo
- CE Vega De La
- CR Lake
- D Boullin
- DE Hier
- DE Hier
- DG Pennington
- DJ Boullin
- DJ Boullin
- DJ Boullin
- DJ Boullin
- DJ Boullin
- DJ Cohen
- DJ Cohen
- DJ Cohen
- DJ Cohen
- DL Meryash
- DL Murphy
- DM Engelhardt
- DR Hanson
- DVS Sankar
- DVS Sankar
- DVS Sankar
- DVS Sankar
- DVS Sankar
- E Costa
- E Friedman
- E Geller
- E Ritvo
- E Ritvo
- EG Torrey
- EL Giller Jr.
- EM Demet
- EM Ornitz
- ER Ritvo
- ER Ritvo
- FM Minter
- G Bertaccini
- G Faretra
- G Lelord
- G Rudnick
- G Stubbs
- GE Vaillant
- GVR Born
- GVR Born
- H Damasio
- H Holmsen
- H Knoblock
- H Schaumburg
- HF Schott
- HG Hanley
- I Kolvin
- I Sauerbier
- IL Cohen
- J Duhault
- J Duhault
- J Sverd
- JA Harvey
- JF Leckman
- JG Young
- JG Young
- JG Young
- JL Costa
- JL Costa
- JL Costa
- JL Costa
- JM Paulus
- JM Sneddon
- JP Tranzer
- K Fuxe
- K Sarai
- L Bender
- L Corash
- L Eisenberg
- L Kanner
- L Pauling
- LE DeLisi
- LS Freedman
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Coleman
- M Goldstein
- M Rutter
- M Rutter
- M Rutter
- MA Spence
- MJ Raleigh
- MJ Raleigh
- MJ Raleigh
- MW Partington
- O Douay
- O Lingjaerde
- O Lingjaerde
- R Villard De
- RA O’Brien
- RH Belmaker
- RJ Schain
- RK Crane
- RM Booyse
- RM Weinshilboum
- RS Williams
- S Chess
- S Corash
- S Folstein
- S Folstein
- S Garattini
- S Garattini
- S Hauser
- S Karpatkin
- S Karpatkin
- S Takahashi
- SM Stahl
- TL Perry
- TP McDonald
- TR Shearer
- V Erspamer
- V Zarcone
- WE Behrens Von
- WE Seifert Jr.
- WT Brown
- Y Hoshino
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1985
- Field of study
The myeloarchitectonic studies on the human cerebral cortex of the Vogt–Vogt school, and their significance for the interpretation of functional neuroimaging data
- Author
- A Anwander
- A Flores
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- A Hopf
- AW Campbell
- B Seltzer
- BA Wandell
- C Economo Von
- C Economo Von
- C Vogt
- C Vogt
- C Vogt
- C Vogt
- C Vogt
- C Vogt
- C Vogt
- D Öngür
- E Beck
- E Beck
- E Beck
- E Beck
- E Gerhardt
- E Gerhardt
- EG Batsch
- EG Jones
- EG Jones
- EG Jones
- EG Jones
- EH Strasburger
- EH Strasburger
- EH Strasburger
- F Kurth
- F Mauss
- F Mauss
- F Sanides
- F Sanides
- F Scheperjans
- F Scheperjans
- G Elliot Smith
- H Braak
- H Brockhaus
- H Johansen-Berg
- HB Uylings
- I Klatzo
- JE Rose
- JE Rose
- JH Kaas
- K Amunts
- K Amunts
- K Amunts
- K Brodmann
- K Brodmann
- K Brodmann
- K Brodmann
- K Brodmann
- K Brodmann
- K Brodmann
- K Brodmann
- K Brodmann
- K Zilles
- K Zilles
- K Zilles
- KE Stephan
- KS Lashley
- M Vogt
- M Vogt
- MF Glasser
- N Palomero-Gallagher
- O Foerster
- O Vogt
- O Vogt
- O Vogt
- O Vogt
- O Vogt
- O Vogt
- O Vogt
- O Vogt
- O Vogt
- P Bailey
- PE Roland
- R Nieuwenhuys
- RE Passingham
- Rudolf Nieuwenhuys
- S Caspers
- S Caspers
- S Geyer
- S Geyer
- SB Eickhoff
- SR Cajal
- ST Carmichael
- ST Carmichael
- ST Carmichael
- ST Carmichael
- T Kaes
- T Meynert
- TE Behrens
- V Braitenberg
- V Braitenberg
- W Lungwitz
- WA Press
- WE Gros Clark Le
- WR Uttal
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A framework for analysing innovation in the food sector.
- Author
- A Booz
- A Craig
- A Craig
- A Day
- A Dreher
- A Griffin
- A Johne
- A Kohli
- AG Sneep
- AJ Cozijnsen
- AK Gupta
- AK Kohli
- B Carlsson
- B Shaw
- B Yon
- BJ Jaworski
- C Gissén
- Commission of the European Communities
- D Archibugi
- D Littler
- DE Abell
- DE Lilienthal
- DJ Teece
- E Hippel von
- E Staudt
- EB Roberts
- EF Shumaker
- F Karakaya
- FA Johne
- FA Johne
- FE Webster Jr
- FM Scherer
- FM Scherer
- FR Dwyer
- G Barczak
- G Fairtlough
- G Galizzi
- G Lilien
- G Mensch
- G Schewe
- GL Urban
- GS Day
- GS Day
- H Geschka
- H Harmsen
- H Harmsen
- H Harmsen
- H Håkansson
- H Nyström
- H Penzkofer
- H Takeuchi
- HH Villard
- HO Armour
- I Barclay
- J Arndt
- J Arndt
- J Frøslev Christensen
- J Hauschildt
- J Sundbo
- J Tirole
- J Townsend
- JA Dawson
- JA Schumpeter
- JB Barney
- JC Narver
- JD Lichtenthal
- JL Christensen
- JM Utterback
- JR Workman
- K Galbraith
- K Lundgren
- K Pavitt
- K Pavitt
- K Plichta
- KG Grunert
- KH Oppenländer
- KR Harrigan
- KR Harrigan
- L Christensen
- L Dwyer
- LH Ansoff
- LW Stern
- M Etgar
- M Leder
- M Maidique
- ME Porter
- National Science Foundation
- OE Williamson
- OE Williamson
- P Clark
- P Cooke
- P Kotler
- PS Kristensen
- PS Kristensen
- R Henderson
- R Rama
- R Rothwell
- R Rothwell
- R Rothwell
- R Rothwell
- R Rothwell
- R Rothwell
- RB Kennard
- RD Buzzell
- RE Miles
- RG Cooper
- RG Cooper
- RG Cooper
- RG Cooper
- RG Cooper
- RG Cooper
- RS Achrol
- RS Achrol
- RW Ruekert
- S Balakrishnan
- S Davies
- S Globerman
- SF Slater
- TE Hambüchen
- TK Madsen
- V Mahajan
- V Sogaard
- W Behrens-Ramberg
- WE Souder
- WG Biemans
- WG Nijkamp
- WJ Abernathy
- WW Powell
- ZJ Acs
- Publication venue
- Blackie Academic & Professional
- Publication date
- 01/01/1997
- Field of study