2,250 research outputs found
The utility of ductal lavage in breast cancer detection and risk assessment
Ductal lavage (DL) permits noninvasive retrieval of epithelial cells from the breast. Clinical development of this technique has been fueled largely by its potential, as yet unproven, to improve detection of breast cancer and definition of individual risk for development of breast cancer. Early studies demonstrate the feasibility of performing this technique, provide data on cellular yield and findings, and demonstrate the ability to measure molecular markers in DL fluid. However, the sensitivity and specificity of DL for the detection of breast cancer remains unknown, as does the significance of atypia, particularly mild atypia, when found in DL fluid. Although DL appears safe and the device is approved by the US Food and Drug Administration, DL is still best utilized in the setting of clinical trials designed to resolve issues of sensitivity, specificity, and localization
Transition to superfluid turbulence governed by an intrinsic parameter
Hydrodynamic flow in both classical and quantum fluids can be either laminar
or turbulent. To describe the latter, vortices in turbulent flow are modelled
with stable vortex filaments. While this is an idealization in classical
fluids, vortices are real topologically stable quantized objects in
superfluids. Thus superfluid turbulence is thought to hold the key to new
understanding on turbulence in general. The fermion superfluid 3He offers
further possibilities owing to a large variation in its hydrodynamic
characteristics over the experimentally accessible temperatures. While studying
the hydrodynamics of the B phase of superfluid 3He, we discovered a sharp
transition at 0.60Tc between two regimes, with regular behaviour at
high-temperatures and turbulence at low-temperatures. Unlike in classical
fluids, this transition is insensitive to velocity and occurs at a temperature
where the dissipative vortex damping drops below a critical limit. This
discovery resolves the conflict between existing high- and low-temperature
measurements in 3He-B: At high temperatures in rotating flow a vortex loop
injected into superflow has been observed to expand monotonically to a single
rectilinear vortex line, while at very low temperatures a tangled network of
quantized vortex lines can be generated in a quiescent bath with a vibrating
wire. The solution of this conflict reveals a new intrinsic criterion for the
existence of superfluid turbulence.Comment: Revtex file; 5 pages, 2 figure
RePAD: Real-time Proactive Anomaly Detection for Time Series
During the past decade, many anomaly detection approaches have been
introduced in different fields such as network monitoring, fraud detection, and
intrusion detection. However, they require understanding of data pattern and
often need a long off-line period to build a model or network for the target
data. Providing real-time and proactive anomaly detection for streaming time
series without human intervention and domain knowledge is highly valuable since
it greatly reduces human effort and enables appropriate countermeasures to be
undertaken before a disastrous damage, failure, or other harmful event occurs.
However, this issue has not been well studied yet. To address it, this paper
proposes RePAD, which is a Real-time Proactive Anomaly Detection algorithm for
streaming time series based on Long Short-Term Memory (LSTM). RePAD utilizes
short-term historic data points to predict and determine whether or not the
upcoming data point is a sign that an anomaly is likely to happen in the near
future. By dynamically adjusting the detection threshold over time, RePAD is
able to tolerate minor pattern change in time series and detect anomalies
either proactively or on time. Experiments based on two time series datasets
collected from the Numenta Anomaly Benchmark demonstrate that RePAD is able to
proactively detect anomalies and provide early warnings in real time without
human intervention and domain knowledge.Comment: 12 pages, 8 figures, the 34th International Conference on Advanced
Information Networking and Applications (AINA 2020
Mathematizing Darwin
Ernst Mayr called the first part of the evolutionary synthesis the ‘Fisherian synthesis’ on account of the dominant role played by R.A. Fisher in forging a mathematical theory of natural selection together with J.B.S. Haldane and Sewall Wright in the decade 1922–1932. It is here argued that Fisher’s contribution relied on a close reading of Darwin’s work to a much greater extent than did the contributions of Haldane and Wright, that it was synthetic in contrast to their analytic approach and that it was greatly influenced by his friendship with the Darwin family, particularly with Charles’s son Leonard
Impact of a parent-child sexual communication campaign: results from a controlled efficacy trial of parents
<p>Abstract</p> <p>Background</p> <p>Prior research supports the notion that parents have the ability to influence their children's decisions regarding sexual behavior. Yet parent-based approaches to curbing teen pregnancy and STDs have been relatively unexplored. The Parents Speak Up National Campaign (PSUNC) is a multimedia campaign that attempts to fill this void by targeting parents of teens to encourage parent-child communication about waiting to have sex. The campaign follows a theoretical framework that identifies cognitions that are targeted in campaign messages and theorized to influence parent-child communication. While a previous experimental study showed PSUNC messages to be effective in increasing parent-child communication, it did not address how these effects manifest through the PSUNC theoretical framework. The current study examines the PSUNC theoretical framework by 1) estimating the impact of PSUNC on specific cognitions identified in the theoretical framework and 2) examining whether those cognitions are indeed associated with parent-child communication</p> <p>Methods</p> <p>Our study consists of a randomized efficacy trial of PSUNC messages under controlled conditions. A sample of 1,969 parents was randomly assigned to treatment (PSUNC exposure) and control (no exposure) conditions. Parents were surveyed at baseline, 4 weeks, 6 months, 12 months, and 18 months post-baseline. Linear regression procedures were used in our analyses. Outcome variables included self-efficacy to communicate with child, long-term outcome expectations that communication would be successful, and norms on appropriate age for sexual initiation. We first estimated multivariable models to test whether these cognitive variables predict parent-child communication longitudinally. Longitudinal change in each cognitive variable was then estimated as a function of treatment condition, controlling for baseline individual characteristics.</p> <p>Results</p> <p>Norms related to appropriate age for sexual initiation and outcome expectations that communication would be successful were predictive of parent-child communication among both mothers and fathers. Treatment condition mothers exhibited larger changes than control mothers in both of these cognitive variables. Fathers exhibited no exposure effects.</p> <p>Conclusions</p> <p>Results suggest that within a controlled setting, the "wait until older norm" and long-term outcome expectations were appropriate cognitions to target and the PSUNC media materials were successful in impacting them, particularly among mothers. This study highlights the importance of theoretical frameworks for parent-focused campaigns that identify appropriate behavioral precursors that are both predictive of a campaign's distal behavioral outcome and sensitive to campaign messages.</p
Incidence and Characteristics of Total Stroke in the United States
BACKGROUND AND PURPOSE: Stroke, increasingly referred to as a "brain attack", is one of the leading causes of death and the leading cause of adult disability in the United States. It has recently been estimated that there were three quarters of a million strokes in the United States in 1995. The aim of this study was to replicate the 1995 estimate and examine if there was an increase from 1995 to 1996 by using a large administrative claims database representative of all 1996 US inpatient discharges. METHODS: We used the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project, release 5, which contains ≈ 20 percent of all 1996 US inpatient discharges. We identified stroke patients by using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes from 430 to 438, and we compared the 1996 database with that of 1995. RESULTS: There were 712,000 occurrences of stroke with hospitalization (95% CI 688,000 to 737,000) and an estimated 71,000 occurrences of stroke without hospitalization. This totaled 783,000 occurrences of stroke in 1996, compared to 750,000 in 1995. The overall rate for occurrence of total stroke (first-ever and recurrent) was 269 per 100,000 population (age- and sex-adjusted to 1996 US population). CONCLUSIONS: We estimate that there were 783,000 first-ever or recurrent strokes in the United States during 1996, compared to the figure of 750,000 in 1995. This study replicates and confirms the previous annual estimates of approximately three quarters of a million total strokes. This slight increase is likely due to the aging of the population and the population gain in the US from 1995 to 1996
Evaluation of Sexual Communication Message Strategies
Parent-child communication about sex is an important proximal reproductive health outcome. But while campaigns to promote it such as the Parents Speak Up National Campaign (PSUNC) have been effective, little is known about how messages influence parental cognitions and behavior. This study examines which message features explain responses to sexual communication messages
SN 2005hj: Evidence for Two Classes of Normal-Bright SNe Ia and Implications for Cosmology
HET Optical spectra covering the evolution from about 6 days before to about
5 weeks after maximum light and the ROTSE-IIIb unfiltered light curve of the
"Branch-normal" Type Ia Supernova SN 2005hj are presented. The host galaxy
shows HII region lines at redshift of z=0.0574, which puts the peak unfiltered
absolute magnitude at a somewhat over-luminous -19.6. The spectra show weak and
narrow SiII lines, and for a period of at least 10 days beginning around
maximum light these profiles do not change in width or depth and they indicate
a constant expansion velocity of ~10,600 km/s. We analyzed the observations
based on detailed radiation dynamical models in the literature. Whereas delayed
detonation and deflagration models have been used to explain the majority of
SNe Ia, they do not predict a long velocity plateau in the SiII minimum with an
unvarying line profile. Pulsating delayed detonations and merger scenarios form
shell-like density structures with properties mostly related to the mass of the
shell, M_shell, and we discuss how these models may explain the observed SiII
line evolution; however, these models are based on spherical calculations and
other possibilities may exist. SN 2005hj is consistent with respect to the
onset, duration, and velocity of the plateau, the peak luminosity and, within
the uncertainties, with the intrinsic colors for models with M_shell=0.2 M_sun.
Our analysis suggests a distinct class of events hidden within the
Branch-normal SNe Ia. If the predicted relations between observables are
confirmed, they may provide a way to separate these two groups. We discuss the
implications of two distinct progenitor classes on cosmological studies
employing SNe Ia, including possible differences in the peak luminosity to
light curve width relation.Comment: ApJ accepted, 31 page
Evaluation of Sexual Communication Message Strategies
Parent-child communication about sex is an important proximal reproductive health outcome. But while campaigns to promote it such as the Parents Speak Up National Campaign (PSUNC) have been effective, little is known about how messages influence parental cognitions and behavior. This study examines which message features explain responses to sexual communication messages
The type Ia supernova SNLS-03D3bb from a super-Chandrasekhar-mass white dwarf star
The acceleration of the expansion of the universe, and the need for Dark
Energy, were inferred from the observations of Type Ia supernovae (SNe Ia).
There is consensus that SNe Ia are thermonuclear explosions that destroy
carbon-oxygen white dwarf stars that accrete matter from a companion star,
although the nature of this companion remains uncertain. SNe Ia are thought to
be reliable distance indicators because they have a standard amount of fuel and
a uniform trigger -- they are predicted to explode when the mass of the white
dwarf nears the Chandrasekhar mass -- 1.4 solar masses. Here we show that the
high redshift supernova SNLS-03D3bb has an exceptionally high luminosity and
low kinetic energy that both imply a super-Chandrasekhar mass progenitor.
Super-Chandrasekhar mass SNe Ia should preferentially occur in a young stellar
population, so this may provide an explanation for the observed trend that
overluminous SNe Ia only occur in young environments. Since this supernova does
not obey the relations that allow them to be calibrated as standard candles,
and since no counterparts have been found at low redshift, future cosmology
studies will have to consider contamination from such events.Comment: 9 pages, 4 figures. To appear in Nature Sept. 21. Accompanying News &
Views in same issue. Supplementary information available at
www.nature.com/natur
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