QCD and strongly coupled gauge theories : challenges and perspectives

We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe

Laser wakefield simulations towards development of compact particle accelerators

Laser driven wakefield accelerators produce accelerating fields thousands of times those achievable in conventional radio-frequency accelerators, offering compactness and ultrafast bunches to potentially extend the frontiers of high energy physics and enable laboratory scale ultrafast radiation sources. Realization of this potential requires understanding of accelerator physics to advance beam performance and stability, and particle simulations model the highly nonlinear, kinetic physics required. One-to-one simulations of experiments provide new insight for optimization and development of 100 MeV to GeV and beyond laser accelerator stages, and on production of reproducible and controllable low energy spread beams with improved emittance (focusability) and energy through control of injection. © 2007 IOP Publishing Ltd

Management of proton pump inhibitor responsive-esophageal eosinophilia and eosinophilic esophagitis: controversies in treatment approaches

Eosinophilic esophagitis (EoE) is a chronic immune mediated clinicopathologic disease. The prevalence of EoE is approximately 1/2000 persons, EoE is now the most common cause of food impactions, and health care expenditures approach $1 billion annually. This paper will discuss challenges related to proton pump inhibitor responsive esophageal eosinophilia (PPI-REE), including distinguishing this condition from EoE and understanding mechanisms of the PPI response. For EoE, we will review multiple ongoing debates about treatment and monitoring strategies, including selecting treatment outcomes, optimizing medication formulations, approaching the steroid-refractory patient, conducting dietary elimination, prescribing long-term maintenance therapy, and performing esophageal dilation