Large Scale Pressure Fluctuations and Sunyaev-Zel'dovich Effect

The Sunyaev-Zel'dovich (SZ) effect associated with pressure fluctuations of the large scale structure gas distribution will be probed with current and upcoming wide-field small angular scale cosmic microwave background experiments. We study the generation of pressure fluctuations by baryons which are present in virialized dark matter halos and by baryons present in small overdensities. For collapsed halos, assuming the gas distribution is in hydrostatic equilibrium with matter density distribution, we predict the pressure power spectrum and bispectrum associated with the large scale structure gas distribution by extending the dark matter halo approach which describes the density field in terms of correlations between and within halos. The projected pressure power spectrum allows a determination of the resulting SZ power spectrum due to virialized structures. The unshocked photoionized baryons present in smaller overdensities trace the Jeans-scale smoothed dark matter distribution. They provide a lower limit to the SZ effect due to large scale structure in the absence of massive collapsed halos. We extend our calculations to discuss higher order statistics, such as bispectrum and skewness in SZ data. The SZ-weak lensing cross-correlation is suggested as a probe of correlations between dark matter and baryon density fields, while the probability distribution functions of peak statistics of SZ halos in wide field CMB data can be used as a probe of cosmology and non-Gaussian evolution of large scale structure pressure fluctuations.Comment: 16 pages, 9 figures; Revised with expanded discussions. Phys. Rev. D. (in press

Tries and conversions: are sports sponsors pursuing the right objectives?

Sports sponsorship is perceived as important in developing relationships with key clients. However, few companies set relationship marketing objectives when sponsoring sports. This paper aims to examine whether sports sponsors are pursuing the right objectives. It concludes that a deeper understanding of the sponsor's relationship marketing objectives could heighten the sponsor's success, thereby reinforcing and sustaining their own relationship with the sponsoring organisation

Radiometal-Labeled Photoactivatable Pt(IV) Anticancer Complex for Theranostic Phototherapy

A novel photoactivatable Pt(IV) diazido anticancer agent, Pt-succ-DFO, bearing a pendant deferoxamine (DFO) siderophore for radiometal chelation, has been synthesized for the study of its in vivo behavior with radionuclide imaging. Pt-succ-DFO complexation of Fe(III) and Ga(III) ions yielded new heterobimetallic complexes that maintain the photoactivation properties and photocytotoxicity of the parent Pt complex in human cancer cell lines. Radiolabeled Pt-succ-DFO-68Ga (t1/2 = 68 min, positron emitter) was readily prepared under mild conditions and was stable in the dark upon incubation with human serum. PET imaging of Pt-succ-DFO-68Ga in healthy mice revealed a promising biodistribution profile with rapid renal excretion and limited organ accumulation, implying that little off-target uptake is expected for this class of agents. Overall, this research provides the first in vivo imaging study of the whole-body distribution of a photoactivatable Pt(IV) azido anticancer complex and illustrates the potential of radionuclide imaging as a tool for the preclinical development of novel light-activated agents.</p