423 research outputs found
Unified Field Theory From Enlarged Transformation Group. The Covariant Derivative for Conservative Coordinate Transformations and Local Frame Transformations
Pandres has developed a theory in which the geometrical structure of a real
four-dimensional space-time is expressed by a real orthonormal tetrad, and the
group of diffeomorphisms is replaced by a larger group called the conservation
group. This paper extends the geometrical foundation for Pandres' theory by
developing an appropriate covariant derivative which is covariant under all
local Lorentz (frame) transformations, including complex Lorentz
transformations, as well as conservative transformations. After defining this
extended covariant derivative, an appropriate Lagrangian and its resulting
field equations are derived. As in Pandres' theory, these field equations
result in a stress-energy tensor that has terms which may automatically
represent the electroweak field. Finally, the theory is extended to include
2-spinors and 4-spinors.Comment: Aug 25 replacement has corrected margin width
The OmniPod Insulin Management System: the latest innovation in insulin pump therapy
This review of insulin pump therapy focuses on the OmniPodÂź Insulin Management System (Insulet Corp., Bedford, MA, USA). The OmniPod System is the first commercially available âpatch pump.â It is a fully integrated wearable pump, controlled wirelessly through a handheld device containing a built-in blood glucose meter. This is an evaluation of the OmniPod System, with the aim of providing an educational tool for physicians who are considering recommending this product to their patients. The review includes a discussion of the traditional insulin pump configuration and its limitations, a detailed overview of the OmniPod System, references to clinical study data, planned product enhancements, its use as an insulin delivery system in the Juvenile Diabetes Research Foundationâs Artificial Pancreas Project, and its use to deliver additional compounds
Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research
A growing body of research suggests a linkage between pubertal mammary gland development and environmental factors such as diet as modifiers of long term breast cancer risk. Much of this research is dependent upon mouse models, which may vary between studies. However, effects may be strain dependent and further modified by diet, which has not been previously examined. Therefore, the objective of the present study was to determine whether mammary gland development differs between FVB and C57Bl/6 strains on diets containing either n-6 or n-3 polyunsaturated fats. Developmental measures related to onset of puberty and mammary gland development differed between strains. Mice fed the n-3 polyunsaturated fatty acids (PUFA) diet were shown to have lower numbers of terminal end buds, a marker of mammary gland development. This study helps to further clarify differences in development and dietary response between FVB and C57Bl/6 mice in order to more appropriately relate mammary gland research to human populations
Mass Transportation on Sub-Riemannian Manifolds
We study the optimal transport problem in sub-Riemannian manifolds where the
cost function is given by the square of the sub-Riemannian distance. Under
appropriate assumptions, we generalize Brenier-McCann's Theorem proving
existence and uniqueness of the optimal transport map. We show the absolute
continuity property of Wassertein geodesics, and we address the regularity
issue of the optimal map. In particular, we are able to show its approximate
differentiability a.e. in the Heisenberg group (and under some weak assumptions
on the measures the differentiability a.e.), which allows to write a weak form
of the Monge-Amp\`ere equation
Self-consistent scattering description of transport in normal-superconductor structures
We present a scattering description of transport in several
normal-superconductor structures. We show that the related requirements of
self-consistency and current conservation introduce qualitative changes in the
transport behavior when the current in the superconductor is not negligible.
The energy thresholds for quasiparticle propagation in the superconductor are
sensitive to the existence of condensate flow (). This dependence is
responsible for a rich variety of transport regimes, including a voltage range
in which only Andreev transmission is possible at the interfaces, and a state
of gapless superconductivity which may survive up to high voltages if
temperature is low. The two main effects of current conservation are a shift
towards lower voltages of the first peak in the differential conductance and an
enhancement of current caused by the greater availability of charge
transmitting scattering channels.Comment: 31 pages, 10 PS figures, Latex file, psfig.sty file is added. To
appear in Phys. Rev. B (Jan 97
Large-scale magnetic fields from inflation in dilaton electromagnetism
The generation of large-scale magnetic fields is studied in dilaton
electromagnetism in inflationary cosmology, taking into account the dilaton's
evolution throughout inflation and reheating until it is stabilized with
possible entropy production. It is shown that large-scale magnetic fields with
observationally interesting strength at the present time could be generated if
the conformal invariance of the Maxwell theory is broken through the coupling
between the dilaton and electromagnetic fields in such a way that the resultant
quantum fluctuations in the magnetic field has a nearly scale-invariant
spectrum. If this condition is met, the amplitude of the generated magnetic
field could be sufficiently large even in the case huge amount of entropy is
produced with the dilution factor as the dilaton decays.Comment: 28 pages, 5 figures, the version accepted for publication in Phys.
Rev. D; some references are adde
Effective killing of the human pathogen Candida albicans by a specific inhibitor of non-essential mitotic kinesin Kip1p
Kinesins from the bipolar (Kinesin-5) family are conserved in eukaryotic organisms and play critical roles during the earliest stages of mitosis to mediate spindle pole body separation and formation of a bipolar mitotic spindle. To date, genes encoding bipolar kinesins have been reported to be essential in all organisms studied. We report the characterization of CaKip1p, the sole member of this family in the human pathogenic yeast Candida albicans. C. albicans Kip1p appears to localize to the mitotic spindle and loss of CaKip1p function interferes with normal progression through mitosis. Inducible excision of CaKIP1 revealed phenotypes unique to C. albicans, including viable homozygous Cakip1 mutants and an aberrant spindle morphology in which multiple spindle poles accumulate in close proximity to each other. Expression of the C. albicans Kip1 motor domain in Escherichia coli produced a protein with microtubule-stimulated ATPase activity that was inhibited by an aminobenzothiazole (ABT) compound in an ATP-competitive fashion. This inhibition results in ârigor-likeâ, tight association with microtubules in vitro. Upon treatment of C. albicans cells with the ABT compound, cells were killed, and terminal phenotype analysis revealed an aberrant spindle morphology similar to that induced by loss of the CaKIP1 gene. The ABT compound discovered is the first example of a fungal spindle inhibitor targeted to a mitotic kinesin. Our results also show that the non-essential nature and implementation of the bipolar motor in C. albicans differs from that seen in other organisms, and suggest that inhibitors of a non-essential mitotic kinesin may offer promise as cidal agents for antifungal drug discovery
Species abundance distributions: moving beyond single prediction theories to integration within an ecological framework
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75247/1/j.1461-0248.2007.01094.x.pd
Climate adaptation for rural water and sanitation systems in the Solomon Islands: A community scale systems model for decision support
Delivering water and sanitation services are challenging in data poor rural settings in developing countries. In this paper we develop a Bayesian Belief Network model that supports decision making to increase the availability of safe drinking water in five flood-prone rural communities in the Solomon Islands. We collected quantitative household survey data and qualitative cultural and environmental knowledge through community focus group discussions. We combined these data to develop our model, which simulates the state of eight water sources and ten sanitation types and how they are affected by season and extreme events. We identify how climate and current practices can threaten the availability of drinking water for remote communities. Modelling of climate and intervention scenarios indicate that water security could be best enhanced through increased rainwater harvesting (assuming proper installation and maintenance). These findings highlight how a systems model can identify links between and improve understanding of water and sanitation, community behaviour, and the impacts of extreme events. The resultant BBN provides a tool for decision support to enhance opportunities for climate resilient water and sanitation service provision
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