The role of monocytes and monocyte-derived dendritic cells in type 1 diabetes mellitus and autoimmune thyroid disease

Type 1 diabetes mellitus (DM1) and autoimmune thyroid disease (AITD) are organ specific autoimmune diseases in which the immune system is directed against the ß cells and the thyrocytes respectively. The etio-pathogenesis of organ-specific or endocrine autoimmune diseases is complex, polygenic and heavily dependent on various environmental influences. The exact etiology of these diseases remains to be clarified, the pathogenesis is strongly associated with autoimmune phenomena. None of current treatment approaches provide a cure, but represent replacement therapies

PRIVACY ISSUES IN ONLINE SOCIAL NETWORKS: USER BEHAVIORS AND THIRD-PARTY APPLICATIONS

In contemporary society, social networking websites has developed dramatically and became an indispensable component in our daily life. Since it can help create a more feature-rich online social community, third-party service has been widely adopted in online social networks (OSNs). Integrating these third-party sites and applications has not only extended business of both social network server and third party and but also promises to break down the garden walls of social-networking sites. While at the same time it dramatically raises concerns on privacy leakage. This article mainly focuses on the privacy disclosure issues caused by user’s behavior and third-party applications and websites. On the one hand, because of the diversity of usage behaviors, the revelation of personal information varies significantly. A survey is conducted to present empirical and quantitative result. On the other hand, the access mechanism between OSN and third party is not perfect enough. Besides, it could be a potential source of privacy leak that third-party services sometimes act as advertisers and information aggregators of a user\u27s traversals. The relevant reasons and internal and external threats are presented. Finally, possible solutions to reduce the increasing information disclosure are provided. Actions should be taken along three fronts: the government, the users themselves as well as the third parties

Education in IT Security: A Case Study in Banking Industry

The banking industry has been changing incessantlyand facing new combination of risks. Data protection andcorporate security is now one of the major issues in bankingindustry. As the rapid changing on technologies from time totime, the industry should be aware on new technologies in orderto protect information assets and prevent fraud activities. Thispaper begins with literature study of information security issuesand followed by focused-group interviews with five participantswithin the industry and survey analysis of “The global state ofInformation Security survey 2013” which published byPriceWaterhouseCoopers (PWC). Trends and questions werediscussed as well as possible solution. The study suggests that ITsecurity education should be made to different level of staffs suchas executives, professional and general staffs. Besides, thebanking industry should increase company-wide securityawareness and the importance of corporate security which keepthe information and physical assets secure and in a proper way

Topological Phase Transition and Electrically Tunable Diamagnetism in Silicene

Silicene is a monolayer of silicon atoms forming a honeycomb lattice. The lattice is actually made of two sublattices with a tiny separation. Silicene is a topological insulator, which is characterized by a full insulating gap in the bulk and helical gapless edges. It undergoes a phase transition from a topological insulator to a band insulator by applying external electric field. Analyzing the spin Chern number based on the effective Dirac theory, we find their origin to be a pseudospin meron in the momentum space. The peudospin degree of freedom arises from the two-sublattice structure. Our analysis makes clear the mechanism how a phase transition occurs from a topological insulator to a band insulator under increasing electric field. We propose a method to determine the critical electric field with the aid of diamagnetism of silicene. Diamagnetism is tunable by the external electric field, and exhibits a singular behaviour at the critical electric field. Our result is important also from the viewpoint of cross correlation between electric field and magnetism. Our finding will be important for future electro-magnetic correlated devices.Comment: 4 pages,5 figure

Association Between Raised Blood Pressure and Dysglycemia in Hong Kong Chinese

OBJECTIVE—To investigate the association between raised blood pressure and dysglycemia

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types