Non-equilibrium Kondo effect in asymmetrically coupled quantum dot

The quantum dot asymmetrically coupled to the external leads has been analysed theoretically by means of the equation of motion (EOM) technique and the non-crossing approximation (NCA). The system has been described by the single impurity Anderson model. To calculate the conductance across the device the non-equilibrium Green's function technique has been used. The obtained results show the importance of the asymmetry of the coupling for the appearance of the Kondo peak at nonzero voltages and qualitatively explain recent experiments.Comment: 7 pages, 6 figures, Physical Review B (accepted for publication

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

Comparison of signal and adaptive sensitivity profiles of the surround mechanism of cat retinal ganglion cells

Signal and adaptive sensitivity profiles of the surrounds of cat retinal ganglion cells were determined by varying the position of concentric annuli whose outside and inside diameters varied but whose total area remained constant. Signal sensitivity profiles were determined by adjusting the luminances of these annuli so as to produce a weak suprathreshold response of constant magnitude and time course. Adaptive sensitivity profiles were determined by varying the luminances of concentric equalarea, unmodulated annuli until the response to a temporally modulated annulus attained a criterion level. The results provided evidence that the retinal region over which the surround mechanism of an X cell pools adaptive information and pools signals are the same, and that the distribution of adaptive and signal sensitivities within these regions is similar. A small number of X cells showed local adaptation effects. The adaptive pooling area appeared to be smaller than the signal pooling area for Y cells

Regression analysis with partially labelled regressors: carbon dating of the Shroud of Turin

The twelve results from the 1988 radio carbon dating of the Shroud of Turin show surprising heterogeneity. We try to explain this lack of homogeneity by regression on spatial coordinates. However, although the locations of the samples sent to the three laboratories involved are known, the locations of the 12 subsamples within these samples are not. We consider all 387,072 plausible spatial allocations and analyse the resulting distributions of statistics. Plots of robust regression residuals from the forward search indicate that some sets of allocations are implausible. We establish the existence of a trend in the results and suggest how better experimental design would have enabled stronger conclusions to have been drawn from this multi-centre experiment