Nonsingular two dimensional cloak of arbitrary shape

We propose a general method to circumvent the singularity of arbitrary 2D cloaks, which arises from infinitely large values of material parameters at inner boundaries. The presented method is based on the deformation view of the transformation design method. It is shown that by adjusting the principle stretch out of the cloaking plane, 2D cloaks of arbitrary shapes without singularity can be constructed. It is also demonstrated that the method based on the equivalent dispersion relation and the design method for nonsingular 2D cloak from mirror-symmetric cross section of 3D cloak can be derived from the proposed theory. Examples of a cylindrical electromagnetic cloak and an arbitrary shaped 2D electromagnetic cloak without singularity are provided to illustrate the method.Comment: 14 pages, 4 figures

Widespread mesoscale dipoles in the global ocean

Mesoscale eddies are ubiquitous and energetic features in the ocean. Although eddies are known to form dipoles from time to time, it is unclear how often they do so. Using satellite altimetry data, here we show that mesoscale dipoles are surprisingly widespread in the global ocean. About 30–40% of the mesoscale eddies identified in altimeter data are paired up as dipoles, and the percentage is even higher in energetic regions such as the Gulf Stream and the Southern Ocean. Composite analysis involving Argo float data further reveals that these mesoscale dipoles have a relatively uniform three-dimensional structure. We find that the presence of mesoscale dipoles can strongly enhance wind Ekman pumping velocity and lead to deep-reaching vertical motions inside the dipoles via eddy deformation and frontogenesis. Such strong vertical exchanges promoted by mesoscale dipoles may play an important role in regulating the Earth's biogeochemical processes

Integrating Healthcare Ethical Issues Into IS Education

Federal initiatives are encouraging the increase of IS graduates to work in the healthcare environment because they possess knowledge of datasets and dataset management that are key to effective management of electronic health records (EHRs) and health information technology (IT). IS graduates will be members of the healthcare team, and as such, they should gain an understanding of bioethics and \u27level the playing field\u27 so that they may meaningfully contribute to the healthcare team. Moreover, they should be mindful of professional ethical codes and common ground that healthcare and IS professions share, particularly with regard to ethical principles of beneficence, autonomy, fidelity, and justice. The purpose of this paper is to present ways to integrate healthcare ethical issues within IS education. To this end, we discuss the notion of a mutual understanding of bioethics and present professional codes of ethics as an advance organizer. We also offer an example ( Fidelity and The Case of Two Datasets ) that may be used in class to illustrate a specific IS healthcare ethical dilemma. Prepared with the knowledge of ethical problems in healthcare organizations, IS professionals can meaningfully contribute to the deliberations and resolutions of the problems that will emerge as more healthcare facilities employ EHRs

Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training

Purpose: Reactive oxygen and nitrogen species are required for exercise-induced molecular adaptations; however, excessive exercise may cause cellular oxidative distress. We postulate that astaxanthin (ASX) can neutralize oxidative distress and stimulate mitochondrial biogenesis in high-intensity exercise-trained mice. Methods: Six-week-old mice (n = 8/group) were treated with ASX (10 mg/kg BW) or placebo. Training groups participated in 30 min/day high-intensity interval training (HIIT) for 6 weeks. Gastrocnemius muscle was collected and assayed following the exercise training period. Results: Compared to the HIIT control mice, the ASX-treated HIIT mice reduced malonaldehyde levels and upregulated the expression of Nrf2 and FOXO3a. Meanwhile, the genes NQO1 and GCLC, modulated by Nrf2, and SOD2, regulated by FOXO3a, and GPx4, were transcriptionally upregulated in the ASX-treated HIIT group. Meanwhile, the expression of energy sensors, AMPK, SIRT1, and SIRT3, increased in the ASX-treated HIIT group compared to the HIIT control group. Additionally, PGC-1α, regulated by AMPK and SIRT1, was upregulated in the ASX-treated HIIT group. Further, the increased PGC-1α stimulated the transcript of NRF1 and Tfam and mitochondrial proteins IDH2 and ATP50. Finally, the ASX-treated HIIT mice had upregulations in the transcript level of mitochondrial fusion factors, including Mfn1, Mfn2, and OPA1. However, the protein level of AMPK, SIRT1, and FOXO3a, and the transcript level of Nrf2, NQO1, PGC-1α, NRF1, Mfn1, Mfn2, and OPA1 decreased in the HIIT control group compared to the sedentary control group. Conclusion: Supplementation with ASX can reduce oxidative stress and promote antioxidant capacity and mitochondrial biogenesis during strenuous HIIT exercise in mice.</p

Novel Non-Toxic Xylene Substitute (SBO) for Histology

Xylene has been generally used as a clearing and deparaffinizing agent in histology. Because of the potential toxic and flammable nature of xylene, its substitutes have been introduced into some laboratories. In this study, we introduced a novel, non-toxic xylene substitute (SBO), which was&nbsp; generated through a mixture of 86% of white oil No.2 and 14% of N-heptane. SBO had a high boiling point (188&deg;C) and flash point (144&deg;C) coupled with a scentless and decreased volatility. To compare the effectiveness of SBO and xylene in histology, a wide range of tissue samples from rats and human beings were processed in parallel in SBO and xylene, subjected to various staining procedures. Similar to the xylene-processed paraffin blocks, the SBO-processed counterparts were easy to section without any evidence of cell shrinkage. Assessment of the SBO-treated sections stained with hematoxylin-eosin revealed a good maintenance of cell morphology and structure, and a clear definition of the cytoplasm and the nucleus. Moreover, comparable good results were achieved between the SBO- and xylene-processed tissues in other histochemical and immunohistochemical stainings. Six-month clinical applications at one department of pathology supported the potentials of SBO as a xylene substitute. In conclusion, we suggest that SBO is a safe and efficient substitute of xylene and may probably replace xylene without losing valuable diagnostic information.Key words: SBO, clearing agent, xylene, histology, toxicit

Structural engineering of pyrrolo[3,4-: F] benzotriazole-5,7(2 H,6 H)-dione-based polymers for non-fullerene organic solar cells with an efficiency over 12%

In this work, we have synthesized two wide band gap donor polymers based on benzo[1,2-b:4,5-b′]dithiophene (BDT) and pyrrolo[3,4-f]benzotriazole-5,7(2H,6H)-dione (TzBI), namely, PBDT-TzBI and PBDT-F-TzBI and studied their photovoltaic properties by blending them with ITIC as an acceptor. Polymer solar cell devices made from PBDT-TzBI:ITIC and PBDT-F-TzBI:ITIC exhibited power conversion efficiencies (PCEs) of 9.22% and 11.02% and while annealing at 160 \ub0C, improved the device performances to 10.24% and 11.98%, respectively. Upon solvent annealing with diphenyl ether (DPE) (0.5%) and chlorobenzene (CB), the PCE of the PBDT-F-TzBI-based device increased to 12.12%. The introduction of the fluorinated benzodithiophene (BDT-F) moiety on the backbone of PBDT-F-TzBI improved the open circuit voltage, short circuit current and fill factor simultaneously. The high PCEs of the PBDT-F-TzBI:ITIC-based devices were supported by comparison and analysis of the optical and electronic properties, the charge carrier mobilities, exciton dissociation probabilities, and charge recombination behaviors of the devices

Catalytic Depolymerization of Lignin and Woody Biomass in Supercritical Ethanol:Influence of Reaction Temperature and Feedstock

The one-step ethanolysis approach to upgrade lignin to monomeric aromatics using a CuMgAl mixed oxide catalyst is studied in detail. The influence of reaction temperature (200-420 °C) on the product distribution is investigated. At low temperature (200-250 °C), recondensation is dominant, while char-forming reactions become significant at high reaction temperature (&gt;380 °C). At preferred intermediate temperatures (300-340 °C), char-forming reactions are effectively suppressed by alkylation and Guerbet and esterification reactions. This shifts the reaction toward depolymerization, explaining high monomeric aromatics yield. Carbon-14 dating analysis of the lignin residue revealed that a substantial amount of the carbon in the lignin residue originates from reactions of lignin with ethanol. Recycling tests show that the activity of the regenerated catalyst was strongly decreased due to a loss of basic sites due to hydrolysis of the MgO function and a loss of surface area due to spinel oxide formation of the Cu and Al components. The utility of this one-step approach for upgrading woody biomass was also demonstrated. An important observation is that conversion of the native lignin contained in the lignocellulosic matrix is much easier than the conversion of technical lignin.</p

Automatic facial landmark labeling with minimal supervision.

Abstract Landmark labeling of training images is essential for many learning tasks in computer vision, such as object detection, tracking, an

Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study.

Background:Observational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression. However, prior reports lacked uniform collection of important confounders such as proteinuria and pre-AKI kidney function trajectory, and may be susceptible to ascertainment bias, as patients may be more likely to undergo kidney function testing after AKI. Methods:We studied 444 adults with CKD who participated in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study and were concurrent members of a large integrated healthcare delivery system. We estimated glomerular filtration rate (eGFR) trajectories using serum creatinine measurements from (i) the CRIC research protocol (yearly) and (ii) routine clinical care. We used linear mixed effects models to evaluate the associations of AKI with acute absolute change in eGFR and post-AKI eGFR slope, and explored whether these varied by source of creatinine results. Models were adjusted for demographic characteristics, diabetes status and albuminuria. Results:During median follow-up of 8.5 years, mean rate of eGFR loss was -0.31 mL/min/1.73&nbsp;m2/year overall, and 73 individuals experienced AKI (55% Stage 1). A significant interaction existed between AKI and source of serum creatinine for acute absolute change in eGFR level after discharge; in contrast, AKI was independently associated with a faster rate of eGFR decline (mean additional loss of -0.67 mL/min/1.73&nbsp;m2/year), which was not impacted by source of serum creatinine. Conclusions:AKI is independently associated with subsequent steeper eGFR decline regardless of the serum creatinine source used, but the strength of association is smaller than observed in prior studies after taking into account key confounders such as pre-AKI eGFR slope and albuminuria